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Tadalafil versus alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive therapy for < 10 mm distal and proximal ureteral stones.
Arch Ital Urol Androl. 2018 Jun 30; 90(2):117-122.AI

Abstract

OBJECTIVES

To evaluate the effect of tadalafil compared with four alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive treatment for ureteral stones in male adults.

MATERIALS AND METHODS

Male adults who were admitted to urology clinic with flank pain and diagnosed with non complicated < 10 mm ureteral stone on non-contrast computed tomography (NCCT) between June 2014-September 2015 were retrospectively evaluated. A total of 273 patients with ureteral stone were divided into five groups. Alfuzosin 10 mg/daily, doxazosin 8 mg/daily, tamsulosin 0.4 mg/daily, silodosin 8 mg/daily and tadalafil 5 mg/daily for 6 weeks were prescribed respectively. Stone localization, diameter, volume and Hounsfield units were noted as NCCT findings. The patients were divided into the two groups based on their stone localization as distal and mid-proximal stones. These two groups were evaluated separately. Expulsion rate were noted at the end of 6 weeks. NCCT and treatment findings were compared between five drug groups in distal and mid-proximal stones separately.

RESULTS

Age was higher in tadalafil group in distal stones (p = 0.032). Expulsion rate was found 78.1% for alfuzosin, 75.7% for doxazosin, 76.5% for tamsulosin, 88.6% for silodosin and 90% for tadalafil in distal (p = 0.44) and 21.7%, 30%, 30%, 30% and 54.5% in mid-proximal stones (p = 0.034) respectively.

CONCLUSIONS

Expulsion rate was higher in silodosin and tadalafil for distal ureteral stones but the difference didn't meet statistical significance. However the expulsion rate was significantly higher in tadalafil than in the other groups for mid-proximal ureteral stones. The result of this study showed that tadalafil may increases ureteric stone expulsion.

Authors+Show Affiliations

Gaziemir Nevvar Salih Isgoren Hospital, Department of Urology, Izmir. serdarcelik84@hotmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29974727

Citation

Çelik, Serdar, et al. "Tadalafil Versus Alpha Blockers (alfuzosin, Doxazosin, Tamsulosin and Silodosin) as Medical Expulsive Therapy for < 10 Mm Distal and Proximal Ureteral Stones." Archivio Italiano Di Urologia, Andrologia : Organo Ufficiale [di] Societa Italiana Di Ecografia Urologica E Nefrologica, vol. 90, no. 2, 2018, pp. 117-122.
Çelik S, Akdeniz F, Afsar Yildirim M, et al. Tadalafil versus alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive therapy for < 10 mm distal and proximal ureteral stones. Arch Ital Urol Androl. 2018;90(2):117-122.
Çelik, S., Akdeniz, F., Afsar Yildirim, M., Bozkurt, O., Gursoy Bulut, M., Hacihasanoglu, M. L., & Demir, O. (2018). Tadalafil versus alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive therapy for < 10 mm distal and proximal ureteral stones. Archivio Italiano Di Urologia, Andrologia : Organo Ufficiale [di] Societa Italiana Di Ecografia Urologica E Nefrologica, 90(2), 117-122. https://doi.org/10.4081/aiua.2018.2.117
Çelik S, et al. Tadalafil Versus Alpha Blockers (alfuzosin, Doxazosin, Tamsulosin and Silodosin) as Medical Expulsive Therapy for < 10 Mm Distal and Proximal Ureteral Stones. Arch Ital Urol Androl. 2018 Jun 30;90(2):117-122. PubMed PMID: 29974727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tadalafil versus alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive therapy for < 10 mm distal and proximal ureteral stones. AU - Çelik,Serdar, AU - Akdeniz,Firat, AU - Afsar Yildirim,Muge, AU - Bozkurt,Ozan, AU - Gursoy Bulut,Merve, AU - Hacihasanoglu,Mehmet Levent, AU - Demir,Omer, Y1 - 2018/06/30/ PY - 2018/03/17/received PY - 2018/04/10/accepted PY - 2018/04/09/revised PY - 2018/7/6/entrez PY - 2018/7/6/pubmed PY - 2019/9/3/medline KW - Alpha blockers KW - Medical expulsive theraphy KW - Ureteral stone KW - tadalafil SP - 117 EP - 122 JF - Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica JO - Arch Ital Urol Androl VL - 90 IS - 2 N2 - OBJECTIVES: To evaluate the effect of tadalafil compared with four alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive treatment for ureteral stones in male adults. MATERIALS AND METHODS: Male adults who were admitted to urology clinic with flank pain and diagnosed with non complicated < 10 mm ureteral stone on non-contrast computed tomography (NCCT) between June 2014-September 2015 were retrospectively evaluated. A total of 273 patients with ureteral stone were divided into five groups. Alfuzosin 10 mg/daily, doxazosin 8 mg/daily, tamsulosin 0.4 mg/daily, silodosin 8 mg/daily and tadalafil 5 mg/daily for 6 weeks were prescribed respectively. Stone localization, diameter, volume and Hounsfield units were noted as NCCT findings. The patients were divided into the two groups based on their stone localization as distal and mid-proximal stones. These two groups were evaluated separately. Expulsion rate were noted at the end of 6 weeks. NCCT and treatment findings were compared between five drug groups in distal and mid-proximal stones separately. RESULTS: Age was higher in tadalafil group in distal stones (p = 0.032). Expulsion rate was found 78.1% for alfuzosin, 75.7% for doxazosin, 76.5% for tamsulosin, 88.6% for silodosin and 90% for tadalafil in distal (p = 0.44) and 21.7%, 30%, 30%, 30% and 54.5% in mid-proximal stones (p = 0.034) respectively. CONCLUSIONS: Expulsion rate was higher in silodosin and tadalafil for distal ureteral stones but the difference didn't meet statistical significance. However the expulsion rate was significantly higher in tadalafil than in the other groups for mid-proximal ureteral stones. The result of this study showed that tadalafil may increases ureteric stone expulsion. SN - 1124-3562 UR - https://www.unboundmedicine.com/medline/citation/29974727/Tadalafil_versus_alpha_blockers_(alfuzosin,_doxazosin,_tamsulosin_and_silodosin)_as_medical_expulsive_therapy_for_<_10_mm_distal_and_proximal_ureteral_stones L2 - https://doi.org/10.4081/aiua.2018.2.117 DB - PRIME DP - Unbound Medicine ER -