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The Potential of Glycemic Control and Body Weight Change as Early Markers for Pancreatic Cancer in Patients With Long-standing Diabetes Mellitus: A Case-Control Study.

Abstract

OBJECTIVES

The aim of this study was to characterize the role of glycemic control and weight change as markers for pancreatic cancer (PaC) in patients with long-standing diabetes.

METHODS

We conducted case-control analyses in patients with long-standing diabetes (>2 years) in the United Kingdom-based Clinical Practice Research Datalink. Cases were patients with PaC matched to control subjects on variables including age, sex, and diabetes duration. We compared glycated hemoglobin (HbA1c) levels, blood glucose levels, and weight change before cancer detection (matched date) between cases and control subjects to assess associations between the potential markers and PaC.

RESULTS

Cases were more likely than control subjects to have high HbA1c levels. The adjusted odds ratio (aOR) was 4.94 (95% confidence interval [CI], 3.52-6.94) for HbA1c of 64.0 mmol/mol or greater compared with HbA1c of 47.5 mmol/mol or less within 6 months before cancer detection and within >1 to 2 years, 2.66 (95% CI, 2.00-3.54). Weight loss was also more common in cases, with an aOR of 15.40 (95% CI, 10.65-22.26) for loss of 15.0% body weight or greater compared with stable weight. The aOR for patients with both weight loss of 15.0% or greater and high HbA1c at 2 years or less before diagnosis was 60.97 (95% CI, 35.87-103.65), compared with patients with neither.

CONCLUSIONS

Poor glycemic control and weight loss, particularly in combination, may be useful early markers for PaC in patients with long-standing diabetes.

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  • Publisher Full Text
  • Authors

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    Source

    Pancreas 47:7 2018 08 pg 807-815

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Biomarkers
    Blood Glucose
    Body Weight
    Case-Control Studies
    Diabetes Mellitus
    Early Detection of Cancer
    Female
    Glycated Hemoglobin A
    Humans
    Male
    Middle Aged
    Pancreatic Neoplasms
    Weight Loss

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    29975346

    Citation

    Mueller, Alexandra M., et al. "The Potential of Glycemic Control and Body Weight Change as Early Markers for Pancreatic Cancer in Patients With Long-standing Diabetes Mellitus: a Case-Control Study." Pancreas, vol. 47, no. 7, 2018, pp. 807-815.
    Mueller AM, Meier CR, Jick SS, et al. The Potential of Glycemic Control and Body Weight Change as Early Markers for Pancreatic Cancer in Patients With Long-standing Diabetes Mellitus: A Case-Control Study. Pancreas. 2018;47(7):807-815.
    Mueller, A. M., Meier, C. R., Jick, S. S., & Schneider, C. (2018). The Potential of Glycemic Control and Body Weight Change as Early Markers for Pancreatic Cancer in Patients With Long-standing Diabetes Mellitus: A Case-Control Study. Pancreas, 47(7), pp. 807-815. doi:10.1097/MPA.0000000000001085.
    Mueller AM, et al. The Potential of Glycemic Control and Body Weight Change as Early Markers for Pancreatic Cancer in Patients With Long-standing Diabetes Mellitus: a Case-Control Study. Pancreas. 2018;47(7):807-815. PubMed PMID: 29975346.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The Potential of Glycemic Control and Body Weight Change as Early Markers for Pancreatic Cancer in Patients With Long-standing Diabetes Mellitus: A Case-Control Study. AU - Mueller,Alexandra M, AU - Meier,Christoph R, AU - Jick,Susan S, AU - Schneider,Cornelia, PY - 2018/7/6/pubmed PY - 2019/1/11/medline PY - 2018/7/6/entrez SP - 807 EP - 815 JF - Pancreas JO - Pancreas VL - 47 IS - 7 N2 - OBJECTIVES: The aim of this study was to characterize the role of glycemic control and weight change as markers for pancreatic cancer (PaC) in patients with long-standing diabetes. METHODS: We conducted case-control analyses in patients with long-standing diabetes (>2 years) in the United Kingdom-based Clinical Practice Research Datalink. Cases were patients with PaC matched to control subjects on variables including age, sex, and diabetes duration. We compared glycated hemoglobin (HbA1c) levels, blood glucose levels, and weight change before cancer detection (matched date) between cases and control subjects to assess associations between the potential markers and PaC. RESULTS: Cases were more likely than control subjects to have high HbA1c levels. The adjusted odds ratio (aOR) was 4.94 (95% confidence interval [CI], 3.52-6.94) for HbA1c of 64.0 mmol/mol or greater compared with HbA1c of 47.5 mmol/mol or less within 6 months before cancer detection and within >1 to 2 years, 2.66 (95% CI, 2.00-3.54). Weight loss was also more common in cases, with an aOR of 15.40 (95% CI, 10.65-22.26) for loss of 15.0% body weight or greater compared with stable weight. The aOR for patients with both weight loss of 15.0% or greater and high HbA1c at 2 years or less before diagnosis was 60.97 (95% CI, 35.87-103.65), compared with patients with neither. CONCLUSIONS: Poor glycemic control and weight loss, particularly in combination, may be useful early markers for PaC in patients with long-standing diabetes. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/29975346/The_Potential_of_Glycemic_Control_and_Body_Weight_Change_as_Early_Markers_for_Pancreatic_Cancer_in_Patients_With_Long_standing_Diabetes_Mellitus:_A_Case_Control_Study_ L2 - http://Insights.ovid.com/pubmed?pmid=29975346 DB - PRIME DP - Unbound Medicine ER -