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Comprehensive quality evaluation and comparison of Angelica sinensis radix and Angelica acutiloba radix by integrated metabolomics and glycomics.
J Food Drug Anal. 2018 07; 26(3):1122-1137.JF

Abstract

Angelica radix (Danggui in Chinese) used in China and Japan is derived from two species of Angelica, namely Angelica sinensis and Angelica acutiloba, respectively. The differences in quality between A. sinensis radix (ASR) and A. acutiloba radix (AAR) should be therefore investigated to guide the medicinal and dietary applications of these two species. Secondary metabolites and carbohydrates have been demonstrated to be the two major kinds of bioactive components of Danggui. However, previously, quality comparison between ASR and AAR intensively concerned secondary metabolites but largely overlooked carbohydrates, thus failing to include or take into consideration an important aspect of the holistic quality of Danggui. In this study, untargeted/targeted metabolomics and glycomics were integrated by multiple chromatography-based analytical techniques for qualitative and quantitative characterization of secondary metabolites and carbohydrates in Danggui so as to comprehensively evaluate and compare the quality of ASR and AAR. The results revealed that not only secondary metabolites but also carbohydrates in ASR and AAR were different in type and amount, which should collectively contribute to their quality difference. By providing more comprehensive chemical information, the research results highlighted the need to assess characteristics of both carbohydrates and secondary metabolites for overall quality evaluation and comparison of ASR and AAR.

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Authors+Show Affiliations

Zhou SS
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.
Xu J
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.
Tsang CK
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.
Yip KM
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.
Yeung WP
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.
Zhao ZZ
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.
Zhu S
Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Fushimi H
Museum of Materia Medica, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Chang HY
School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan.
Chen HB
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.

MeSH

AngelicaAngelica sinensisCarbohydratesChromatographyDrugs, Chinese HerbalGlycomicsMetabolomicsPlant RootsQuality ControlSecondary Metabolism

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29976405

Citation

Zhou, Shan-Shan, et al. "Comprehensive Quality Evaluation and Comparison of Angelica Sinensis Radix and Angelica Acutiloba Radix By Integrated Metabolomics and Glycomics." Journal of Food and Drug Analysis, vol. 26, no. 3, 2018, pp. 1122-1137.
Zhou SS, Xu J, Tsang CK, et al. Comprehensive quality evaluation and comparison of Angelica sinensis radix and Angelica acutiloba radix by integrated metabolomics and glycomics. J Food Drug Anal. 2018;26(3):1122-1137.
Zhou, S. S., Xu, J., Tsang, C. K., Yip, K. M., Yeung, W. P., Zhao, Z. Z., Zhu, S., Fushimi, H., Chang, H. Y., & Chen, H. B. (2018). Comprehensive quality evaluation and comparison of Angelica sinensis radix and Angelica acutiloba radix by integrated metabolomics and glycomics. Journal of Food and Drug Analysis, 26(3), 1122-1137. https://doi.org/10.1016/j.jfda.2018.01.015
Zhou SS, et al. Comprehensive Quality Evaluation and Comparison of Angelica Sinensis Radix and Angelica Acutiloba Radix By Integrated Metabolomics and Glycomics. J Food Drug Anal. 2018;26(3):1122-1137. PubMed PMID: 29976405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comprehensive quality evaluation and comparison of Angelica sinensis radix and Angelica acutiloba radix by integrated metabolomics and glycomics. AU - Zhou,Shan-Shan, AU - Xu,Jun, AU - Tsang,Chuen-Kam, AU - Yip,Ka-Man, AU - Yeung,Wing-Ping, AU - Zhao,Zhong-Zhen, AU - Zhu,Shu, AU - Fushimi,Hirotoshi, AU - Chang,Heng-Yuan, AU - Chen,Hu-Biao, Y1 - 2018/02/15/ PY - 2017/08/22/received PY - 2018/01/11/revised PY - 2018/01/22/accepted PY - 2018/7/7/entrez PY - 2018/7/7/pubmed PY - 2019/9/26/medline KW - Angelica acutiloba radix KW - Angelica sinensis radix KW - Glycomics KW - Metabolomics KW - Quality evaluation SP - 1122 EP - 1137 JF - Journal of food and drug analysis JO - J Food Drug Anal VL - 26 IS - 3 N2 - Angelica radix (Danggui in Chinese) used in China and Japan is derived from two species of Angelica, namely Angelica sinensis and Angelica acutiloba, respectively. The differences in quality between A. sinensis radix (ASR) and A. acutiloba radix (AAR) should be therefore investigated to guide the medicinal and dietary applications of these two species. Secondary metabolites and carbohydrates have been demonstrated to be the two major kinds of bioactive components of Danggui. However, previously, quality comparison between ASR and AAR intensively concerned secondary metabolites but largely overlooked carbohydrates, thus failing to include or take into consideration an important aspect of the holistic quality of Danggui. In this study, untargeted/targeted metabolomics and glycomics were integrated by multiple chromatography-based analytical techniques for qualitative and quantitative characterization of secondary metabolites and carbohydrates in Danggui so as to comprehensively evaluate and compare the quality of ASR and AAR. The results revealed that not only secondary metabolites but also carbohydrates in ASR and AAR were different in type and amount, which should collectively contribute to their quality difference. By providing more comprehensive chemical information, the research results highlighted the need to assess characteristics of both carbohydrates and secondary metabolites for overall quality evaluation and comparison of ASR and AAR. SN - 2224-6614 UR - https://www.unboundmedicine.com/medline/citation/29976405/Comprehensive_quality_evaluation_and_comparison_of_Angelica_sinensis_radix_and_Angelica_acutiloba_radix_by_integrated_metabolomics_and_glycomics_ DB - PRIME DP - Unbound Medicine ER -