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Ag₂O on ZrO₂ as a Recyclable Catalyst for Multicomponent Synthesis of Indenopyrimidine Derivatives.
Molecules. 2018 Jul 05; 23(7)M

Abstract

We describe the synthesis of silver loaded on zirconia and its use as an efficient catalyst for a one-pot three-component reaction to synthesize 11 indenopyrimidine derivatives, of which 7 are new compounds. The procedure involves substituted benzaldehydes, indane-1,3-dione, and guanidinium hydrochloride, with ethanol as solvent. The proposed green protocol at room temperature is simple and efficient, giving excellent yields (90⁻96%) in short reaction times (<30 min). The protocol works well according to the green chemistry principles with respect to high atom economy, no need for column separation, and reusability of the catalyst, which are attractive features. XRD, TEM, SEM, and BET analysis were used to characterize the catalyst materials.

Authors+Show Affiliations

School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa. Saisandeep93@gmail.com.School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa. sureshmskt@gmail.com.School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa. vanzylw@ukzn.ac.za.School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa. jonnalagaddas@ukzn.ac.za.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29976914

Citation

Bhaskaruni, Sandeep V H S., et al. "Ag₂O On ZrO₂ as a Recyclable Catalyst for Multicomponent Synthesis of Indenopyrimidine Derivatives." Molecules (Basel, Switzerland), vol. 23, no. 7, 2018.
Bhaskaruni SVHS, Maddila S, van Zyl WE, et al. Ag₂O on ZrO₂ as a Recyclable Catalyst for Multicomponent Synthesis of Indenopyrimidine Derivatives. Molecules. 2018;23(7).
Bhaskaruni, S. V. H. S., Maddila, S., van Zyl, W. E., & Jonnalagadda, S. B. (2018). Ag₂O on ZrO₂ as a Recyclable Catalyst for Multicomponent Synthesis of Indenopyrimidine Derivatives. Molecules (Basel, Switzerland), 23(7). https://doi.org/10.3390/molecules23071648
Bhaskaruni SVHS, et al. Ag₂O On ZrO₂ as a Recyclable Catalyst for Multicomponent Synthesis of Indenopyrimidine Derivatives. Molecules. 2018 Jul 5;23(7) PubMed PMID: 29976914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ag₂O on ZrO₂ as a Recyclable Catalyst for Multicomponent Synthesis of Indenopyrimidine Derivatives. AU - Bhaskaruni,Sandeep V H S, AU - Maddila,Suresh, AU - van Zyl,Werner E, AU - Jonnalagadda,Sreekantha B, Y1 - 2018/07/05/ PY - 2018/05/22/received PY - 2018/07/02/revised PY - 2018/07/03/accepted PY - 2018/7/7/entrez PY - 2018/7/7/pubmed PY - 2018/10/18/medline KW - Ag2O/ZrO2 KW - green chemistry KW - heterogeneous catalysis KW - indenopyrimidines KW - mixed oxides KW - no column chromatography JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 7 N2 - We describe the synthesis of silver loaded on zirconia and its use as an efficient catalyst for a one-pot three-component reaction to synthesize 11 indenopyrimidine derivatives, of which 7 are new compounds. The procedure involves substituted benzaldehydes, indane-1,3-dione, and guanidinium hydrochloride, with ethanol as solvent. The proposed green protocol at room temperature is simple and efficient, giving excellent yields (90⁻96%) in short reaction times (<30 min). The protocol works well according to the green chemistry principles with respect to high atom economy, no need for column separation, and reusability of the catalyst, which are attractive features. XRD, TEM, SEM, and BET analysis were used to characterize the catalyst materials. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/29976914/Ag₂O_on_ZrO₂_as_a_Recyclable_Catalyst_for_Multicomponent_Synthesis_of_Indenopyrimidine_Derivatives_ L2 - http://www.mdpi.com/resolver?pii=molecules23071648 DB - PRIME DP - Unbound Medicine ER -