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Molecular confirmation and anthelmintic efficacy assessment against natural trichurid infections in zoo-housed non-human primates.
J Med Primatol. 2018 12; 47(6):388-392.JM

Abstract

INTRODUCTION

This study aimed to assess Trichuris species infection and evaluate the anthelmintic efficacy of fenbendazole and ivermectin against natural trichurid infections in non-human primates (NHPs), kept at Mahendra Chaudhury (MC) Zoological Park, Chhatbir, India.

MATERIALS AND METHODS

Molecular confirmation of Trichuris infection was carried out using polymerase chain reaction targeting internal transcribed spacer sequences, and anthelmintic efficacy was assessed by fecal egg count reduction test, respectively.

RESULTS

A 710 base pair product confirmed Trichuris species infection in NHPs. Fenbendazole, 10 mg/kg body weight orally for 5 consecutive days and ivermectin, 100 μg/kg body weight orally for 3 alternate days proved effective and showed a maximum fecal egg reduction of 99.20% and 100% (P < .05) at day 7 post-treatment.

CONCLUSIONS

This study highlighted the molecular confirmation of Trichuris species in non-human primates and its management using fenbendazole and ivermectin.

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Authors+Show Affiliations

Moudgil AD
Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
Singla LD
Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.

MeSH

AnimalsAnimals, ZooAnthelminticsColobinaeFecesFenbendazoleIndiaIvermectinMacaca mulattaMacaca nemestrinaMonkey DiseasesOvumPapio hamadryasTrichuriasisTrichuris

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29979810

Citation

Moudgil, Aman Dev, and Lachhman Das Singla. "Molecular Confirmation and Anthelmintic Efficacy Assessment Against Natural Trichurid Infections in Zoo-housed Non-human Primates." Journal of Medical Primatology, vol. 47, no. 6, 2018, pp. 388-392.
Moudgil AD, Singla LD. Molecular confirmation and anthelmintic efficacy assessment against natural trichurid infections in zoo-housed non-human primates. J Med Primatol. 2018;47(6):388-392.
Moudgil, A. D., & Singla, L. D. (2018). Molecular confirmation and anthelmintic efficacy assessment against natural trichurid infections in zoo-housed non-human primates. Journal of Medical Primatology, 47(6), 388-392. https://doi.org/10.1111/jmp.12358
Moudgil AD, Singla LD. Molecular Confirmation and Anthelmintic Efficacy Assessment Against Natural Trichurid Infections in Zoo-housed Non-human Primates. J Med Primatol. 2018;47(6):388-392. PubMed PMID: 29979810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular confirmation and anthelmintic efficacy assessment against natural trichurid infections in zoo-housed non-human primates. AU - Moudgil,Aman Dev, AU - Singla,Lachhman Das, Y1 - 2018/07/06/ PY - 2018/06/04/accepted PY - 2018/7/7/pubmed PY - 2019/10/15/medline PY - 2018/7/7/entrez KW - Trichuris KW - fenbendazole KW - ivermectin KW - non-human primates KW - polymerase chain reaction KW - resistance SP - 388 EP - 392 JF - Journal of medical primatology JO - J. Med. Primatol. VL - 47 IS - 6 N2 - INTRODUCTION: This study aimed to assess Trichuris species infection and evaluate the anthelmintic efficacy of fenbendazole and ivermectin against natural trichurid infections in non-human primates (NHPs), kept at Mahendra Chaudhury (MC) Zoological Park, Chhatbir, India. MATERIALS AND METHODS: Molecular confirmation of Trichuris infection was carried out using polymerase chain reaction targeting internal transcribed spacer sequences, and anthelmintic efficacy was assessed by fecal egg count reduction test, respectively. RESULTS: A 710 base pair product confirmed Trichuris species infection in NHPs. Fenbendazole, 10 mg/kg body weight orally for 5 consecutive days and ivermectin, 100 μg/kg body weight orally for 3 alternate days proved effective and showed a maximum fecal egg reduction of 99.20% and 100% (P < .05) at day 7 post-treatment. CONCLUSIONS: This study highlighted the molecular confirmation of Trichuris species in non-human primates and its management using fenbendazole and ivermectin. SN - 1600-0684 UR - https://www.unboundmedicine.com/medline/citation/29979810/Molecular_confirmation_and_anthelmintic_efficacy_assessment_against_natural_trichurid_infections_in_zoo_housed_non_human_primates_ L2 - https://doi.org/10.1111/jmp.12358 DB - PRIME DP - Unbound Medicine ER -

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