Abstract
INTRODUCTION
This study aimed to assess Trichuris species infection and evaluate the anthelmintic efficacy of fenbendazole and ivermectin against natural trichurid infections in non-human primates (NHPs), kept at Mahendra Chaudhury (MC) Zoological Park, Chhatbir, India.
MATERIALS AND METHODS
Molecular confirmation of Trichuris infection was carried out using polymerase chain reaction targeting internal transcribed spacer sequences, and anthelmintic efficacy was assessed by fecal egg count reduction test, respectively.
RESULTS
A 710 base pair product confirmed Trichuris species infection in NHPs. Fenbendazole, 10 mg/kg body weight orally for 5 consecutive days and ivermectin, 100 μg/kg body weight orally for 3 alternate days proved effective and showed a maximum fecal egg reduction of 99.20% and 100% (P < .05) at day 7 post-treatment.
CONCLUSIONS
This study highlighted the molecular confirmation of Trichuris species in non-human primates and its management using fenbendazole and ivermectin.
TY - JOUR
T1 - Molecular confirmation and anthelmintic efficacy assessment against natural trichurid infections in zoo-housed non-human primates.
AU - Moudgil,Aman Dev,
AU - Singla,Lachhman Das,
Y1 - 2018/07/06/
PY - 2018/06/04/accepted
PY - 2018/7/7/pubmed
PY - 2019/10/15/medline
PY - 2018/7/7/entrez
KW - Trichuris
KW - fenbendazole
KW - ivermectin
KW - non-human primates
KW - polymerase chain reaction
KW - resistance
SP - 388
EP - 392
JF - Journal of medical primatology
JO - J Med Primatol
VL - 47
IS - 6
N2 - INTRODUCTION: This study aimed to assess Trichuris species infection and evaluate the anthelmintic efficacy of fenbendazole and ivermectin against natural trichurid infections in non-human primates (NHPs), kept at Mahendra Chaudhury (MC) Zoological Park, Chhatbir, India. MATERIALS AND METHODS: Molecular confirmation of Trichuris infection was carried out using polymerase chain reaction targeting internal transcribed spacer sequences, and anthelmintic efficacy was assessed by fecal egg count reduction test, respectively. RESULTS: A 710 base pair product confirmed Trichuris species infection in NHPs. Fenbendazole, 10 mg/kg body weight orally for 5 consecutive days and ivermectin, 100 μg/kg body weight orally for 3 alternate days proved effective and showed a maximum fecal egg reduction of 99.20% and 100% (P < .05) at day 7 post-treatment. CONCLUSIONS: This study highlighted the molecular confirmation of Trichuris species in non-human primates and its management using fenbendazole and ivermectin.
SN - 1600-0684
UR - https://www.unboundmedicine.com/medline/citation/29979810/Molecular_confirmation_and_anthelmintic_efficacy_assessment_against_natural_trichurid_infections_in_zoo_housed_non_human_primates_
L2 - https://doi.org/10.1111/jmp.12358
DB - PRIME
DP - Unbound Medicine
ER -