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Prevalence and characteristics of metabolic syndrome in gout patients in a hospital setting in sub-Saharan Africa.
Diabetes Metab Syndr. 2018 Nov; 12(6):1007-1011.DM

Abstract

BACKGROUND

Evidence from epidemiological studies suggests an important association between gout and the metabolic syndrome (MetS). However, to the best of our knowledge, prevalence of metabolic syndrome in gout has not been reported in sub-Saharan African (SSA) settings.

OBJECTIVES

The aim of this study was to determine the prevalence and characteristics of MetS in gout in a SSA population.

METHOD

After prior ethical clearance, we carried out a cross-sectional study involving gout patients in a referral hospital in Douala-Cameroon. Metabolic syndrome was defined using International Diabetes Foundation criteria. Associations between variables were assessed using logistic regression.p < 0.05 was considered significant.

RESULTS

On 174 gout patients (48.3% females) who consented to participate in the study, the median (IQR) age was 55.00 (14.25) years, and the median (IQR) duration of gout was 7.5 (10.0) years. Prevalence of metabolic syndrome was 54.6% (95% CI: 47.9%-62.8%). One hundred and forty-seven (84.5%) participants had central obesity, 62 (35.6%) raised triglycerides, 79 (45.4%) reduced HDL-C, 129 (74.1%) raised blood pressure, and 85 (48.9%) had raised fasting plasma glucose. On logistic regression analyses, gout patients with metabolic syndrome significantly had a higher body mass index (OR: 1.09, 95% CI: 1.02-1.17), and higher levels of serum uric acid (OR: 1.02, 95% CI: 1.01-1.04).

CONCLUSIONS

About 1 out of every 2 gout patients in this population have metabolic syndrome. These gout patients with metabolic syndrome significantly have a higher body mass index, and higher levels of serum uric acid. Cohort studies are required to clearly establish the direction of the relationship between gout and metabolic syndrome.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Doualla-Bija M
Faculty of Medicine and Biomedical Sciences UY I, Yaoundé, Cameroon; General Hospital, Douala, Cameroon. Electronic address: marie.doualla@gmail.com.
Lobe Batchama Y
Faculty of Medicine and Biomedical Sciences UY I, Yaoundé, Cameroon. Electronic address: lobeyonie@gmail.com.
Moutchia-Suh J
General Hospital, Douala, Cameroon. Electronic address: msjude27@gmail.com.
Ama Moor VJ
Faculty of Medicine and Biomedical Sciences UY I, Yaoundé, Cameroon. Electronic address: movicky@yahoo.fr.
Kamdem F
General Hospital, Douala, Cameroon. Electronic address: Kamdem_djimegne@yahoo.fr.
Lekpa FK
General Hospital, Douala, Cameroon. Electronic address: fklekpa@yahoo.fr.
Luma Namme H
Faculty of Medicine and Biomedical Sciences UY I, Yaoundé, Cameroon. Electronic address: hnluma@yahoo.com.

MeSH

AdultAgedCameroonCross-Sectional StudiesGoutHumansMetabolic SyndromeMiddle AgedPrevalence

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29980454

Citation

Doualla-Bija, Marie, et al. "Prevalence and Characteristics of Metabolic Syndrome in Gout Patients in a Hospital Setting in sub-Saharan Africa." Diabetes & Metabolic Syndrome, vol. 12, no. 6, 2018, pp. 1007-1011.
Doualla-Bija M, Lobe Batchama Y, Moutchia-Suh J, et al. Prevalence and characteristics of metabolic syndrome in gout patients in a hospital setting in sub-Saharan Africa. Diabetes Metab Syndr. 2018;12(6):1007-1011.
Doualla-Bija, M., Lobe Batchama, Y., Moutchia-Suh, J., Ama Moor, V. J., Kamdem, F., Lekpa, F. K., & Luma Namme, H. (2018). Prevalence and characteristics of metabolic syndrome in gout patients in a hospital setting in sub-Saharan Africa. Diabetes & Metabolic Syndrome, 12(6), 1007-1011. https://doi.org/10.1016/j.dsx.2018.06.015
Doualla-Bija M, et al. Prevalence and Characteristics of Metabolic Syndrome in Gout Patients in a Hospital Setting in sub-Saharan Africa. Diabetes Metab Syndr. 2018;12(6):1007-1011. PubMed PMID: 29980454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and characteristics of metabolic syndrome in gout patients in a hospital setting in sub-Saharan Africa. AU - Doualla-Bija,Marie, AU - Lobe Batchama,Yonathan, AU - Moutchia-Suh,Jude, AU - Ama Moor,Vicky Joceline, AU - Kamdem,Félicité, AU - Lekpa,Fernando Kemta, AU - Luma Namme,Henry, Y1 - 2018/06/28/ PY - 2018/06/05/received PY - 2018/06/20/accepted PY - 2018/7/8/pubmed PY - 2019/1/8/medline PY - 2018/7/8/entrez KW - Africa KW - Gout KW - Hyperuricemia KW - Metabolic syndrome SP - 1007 EP - 1011 JF - Diabetes & metabolic syndrome JO - Diabetes Metab Syndr VL - 12 IS - 6 N2 - BACKGROUND: Evidence from epidemiological studies suggests an important association between gout and the metabolic syndrome (MetS). However, to the best of our knowledge, prevalence of metabolic syndrome in gout has not been reported in sub-Saharan African (SSA) settings. OBJECTIVES: The aim of this study was to determine the prevalence and characteristics of MetS in gout in a SSA population. METHOD: After prior ethical clearance, we carried out a cross-sectional study involving gout patients in a referral hospital in Douala-Cameroon. Metabolic syndrome was defined using International Diabetes Foundation criteria. Associations between variables were assessed using logistic regression.p < 0.05 was considered significant. RESULTS: On 174 gout patients (48.3% females) who consented to participate in the study, the median (IQR) age was 55.00 (14.25) years, and the median (IQR) duration of gout was 7.5 (10.0) years. Prevalence of metabolic syndrome was 54.6% (95% CI: 47.9%-62.8%). One hundred and forty-seven (84.5%) participants had central obesity, 62 (35.6%) raised triglycerides, 79 (45.4%) reduced HDL-C, 129 (74.1%) raised blood pressure, and 85 (48.9%) had raised fasting plasma glucose. On logistic regression analyses, gout patients with metabolic syndrome significantly had a higher body mass index (OR: 1.09, 95% CI: 1.02-1.17), and higher levels of serum uric acid (OR: 1.02, 95% CI: 1.01-1.04). CONCLUSIONS: About 1 out of every 2 gout patients in this population have metabolic syndrome. These gout patients with metabolic syndrome significantly have a higher body mass index, and higher levels of serum uric acid. Cohort studies are required to clearly establish the direction of the relationship between gout and metabolic syndrome. SN - 1878-0334 UR - https://www.unboundmedicine.com/medline/citation/29980454/Prevalence_and_characteristics_of_metabolic_syndrome_in_gout_patients_in_a_hospital_setting_in_sub_Saharan_Africa_ DB - PRIME DP - Unbound Medicine ER -