Tags

Type your tag names separated by a space and hit enter

Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells from 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity.
Pharmacology. 2018; 102(3-4):126-132.P

Abstract

Cyanidin is an anthocyanidin extracted from a variety of fruits and vegetables. Cyanidin showed benefits against diabetes, cancer, and atherosclerosis. However, the potential neuroprotective effects of cyanidin against Parkinson's disease (PD) have not been examined. Indicated concentrations of cyanidin (1, 3, 10, and 30 μmol/L) were incubated together with 0.5 mmol/L 1-methyl-4-phenylpyridinium (MPP+) to human neuroblastoma SH-SY5Y cells. We found cyanidin prevented MPP+-induced cell demise in a concentration-dependent manner. Cyanidin significantly reduced MPP+-induced apoptosis, this is reflected by decreased TdT-mediated dUTP nick-end labeling staining and caspase-3 expressions. Further, MPP+ increased the Bax/Bcl-2 ratio, which was partly reversed by cyanidin. We also found cyanidin attenuated the MPP+-induced mitochondrial oxidative stress as revealed by decreased MitoSOX staining. Taken together, these data for the first time indicated the -neuroprotective effects of cyanidin against MPP+-induced -SH-SY5Y cell death. These findings shed light on the potential implications of cyanidin for PD treatment.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Chen J
Department of Anesthesiology, Enze Women's and Children's Hospital Affiliated with Taizhou Enze Medical Center (group), Taizhou, China.
Sun J
School of Pharmacy, Wenzhou Medical Medical University, Wenzhou, China.
Jiang J
Taizhou Women's and Children's Hospital, Wenzhou Medical University, Taizhou, China.
Zhou J
School of Pharmacy, Wenzhou Medical Medical University, Wenzhou, China.

MeSH

1-Methyl-4-phenylpyridiniumAnthocyaninsApoptosisCaspase 3Cell Line, TumorCell SurvivalDopaminergic NeuronsDrug InteractionsHumansMitochondriaNeuroblastomaNeuroprotective AgentsOxidative StressParkinson DiseasePhenanthridinesProto-Oncogene Proteins c-bcl-2Reactive Oxygen Speciesbcl-2-Associated X Protein

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29982258

Citation

Chen, Jian, et al. "Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells From 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity." Pharmacology, vol. 102, no. 3-4, 2018, pp. 126-132.
Chen J, Sun J, Jiang J, et al. Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells from 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity. Pharmacology. 2018;102(3-4):126-132.
Chen, J., Sun, J., Jiang, J., & Zhou, J. (2018). Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells from 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity. Pharmacology, 102(3-4), 126-132. https://doi.org/10.1159/000489853
Chen J, et al. Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells From 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity. Pharmacology. 2018;102(3-4):126-132. PubMed PMID: 29982258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells from 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity. AU - Chen,Jian, AU - Sun,Jian, AU - Jiang,Julian, AU - Zhou,Jie, Y1 - 2018/07/06/ PY - 2017/12/18/received PY - 2018/05/07/accepted PY - 2018/7/10/pubmed PY - 2018/11/28/medline PY - 2018/7/9/entrez KW - 1-methyl-4-phenylpyridinium KW - Cyanidin KW - Neuroprotective effects KW - Parkinson’s disease KW - SH-SY5Y SP - 126 EP - 132 JF - Pharmacology JO - Pharmacology VL - 102 IS - 3-4 N2 - Cyanidin is an anthocyanidin extracted from a variety of fruits and vegetables. Cyanidin showed benefits against diabetes, cancer, and atherosclerosis. However, the potential neuroprotective effects of cyanidin against Parkinson's disease (PD) have not been examined. Indicated concentrations of cyanidin (1, 3, 10, and 30 μmol/L) were incubated together with 0.5 mmol/L 1-methyl-4-phenylpyridinium (MPP+) to human neuroblastoma SH-SY5Y cells. We found cyanidin prevented MPP+-induced cell demise in a concentration-dependent manner. Cyanidin significantly reduced MPP+-induced apoptosis, this is reflected by decreased TdT-mediated dUTP nick-end labeling staining and caspase-3 expressions. Further, MPP+ increased the Bax/Bcl-2 ratio, which was partly reversed by cyanidin. We also found cyanidin attenuated the MPP+-induced mitochondrial oxidative stress as revealed by decreased MitoSOX staining. Taken together, these data for the first time indicated the -neuroprotective effects of cyanidin against MPP+-induced -SH-SY5Y cell death. These findings shed light on the potential implications of cyanidin for PD treatment. SN - 1423-0313 UR - https://www.unboundmedicine.com/medline/citation/29982258/Cyanidin_Protects_SH_SY5Y_Human_Neuroblastoma_Cells_from_1_Methyl_4_Phenylpyridinium_Induced_Neurotoxicity_ DB - PRIME DP - Unbound Medicine ER -