Tags

Type your tag names separated by a space and hit enter

Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release.
Mar Biotechnol (NY). 2018 Dec; 20(6):706-717.MB

Abstract

The aims of the present study were to characterize for the first time the carrageenan extracted from cystocarpic stage of S. crispata collected in the Patagonian coast of Argentina, and to prepare interpolyelectrolytic complexes (IPECs) between the polysaccharide extracted from cystocarpic stage of Sarcothalia crispata and Gigartina skottsbergii thalli, and basic butylated methacrylate copolymer (Eudragit E), in order to test their potential for the controlled release of ibuprofen as model drug. The structural determination revealed that the polysaccharides extracted from S. crispata and G. skottsbergii were mainly constituted by κ-carrageenan, particularly in the case of G. skottsbergii; however, significant amounts of ι- and ν-carrageenan were also detected in both polygalactans. The differences in diad composition and possibly in their distribution along the polysaccharide chain of both carrageenans would favor a different arrangement in the resulting IPEC structure. The smaller pores observed by scanning electron microscopy in the IPEC of S. crispata suggest that the kinks in the polysaccharide backbone are evenly distributed, resulting in a slower ibuprofen release compared to the IPEC of G. skottsbergii.

Authors+Show Affiliations

Centro de Recursos Naturales Renovables de la Zona Semiárida (CERZOS) CONICET-UNS, Camino La Carrindanga Km 7, 8000, Bahía Blanca, Argentina. Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000, Bahía Blanca, Argentina.Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, PINMATE-Departamento de Industrias, Ciudad Universitaria, 1428EGA, Buenos Aires, Argentina. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica II, Junín 956, 1113AAD, Buenos Aires, Argentina.Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Ciudad Universitaria, 1428EGA, Buenos Aires, Argentina. Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Centro de Investigación en Hidratos de Carbono (CIHIDECAR), Facultad de Ciencias Exactas y Naturales,Departamento de Química Orgánica, Ciudad Universitaria, 1428EGA, Buenos Aires, Argentina.Centro de Recursos Naturales Renovables de la Zona Semiárida (CERZOS) CONICET-UNS, Camino La Carrindanga Km 7, 8000, Bahía Blanca, Argentina. Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000, Bahía Blanca, Argentina.Centro de Recursos Naturales Renovables de la Zona Semiárida (CERZOS) CONICET-UNS, Camino La Carrindanga Km 7, 8000, Bahía Blanca, Argentina. Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000, Bahía Blanca, Argentina.Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Centro de Investigación en Hidratos de Carbono (CIHIDECAR), Facultad de Ciencias Exactas y Naturales,Departamento de Química Orgánica, Ciudad Universitaria, 1428EGA, Buenos Aires, Argentina. cristina@qo.fcen.uba.ar.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29984380

Citation

Hughes, Melanie Hebe, et al. "Carrageenans From Sarcothalia Crispata and Gigartina Skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release." Marine Biotechnology (New York, N.Y.), vol. 20, no. 6, 2018, pp. 706-717.
Hughes MH, Prado HJ, Rodríguez MC, et al. Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release. Mar Biotechnol (NY). 2018;20(6):706-717.
Hughes, M. H., Prado, H. J., Rodríguez, M. C., Michetti, K., Leonardi, P. I., & Matulewicz, M. C. (2018). Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release. Marine Biotechnology (New York, N.Y.), 20(6), 706-717. https://doi.org/10.1007/s10126-018-9842-4
Hughes MH, et al. Carrageenans From Sarcothalia Crispata and Gigartina Skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release. Mar Biotechnol (NY). 2018;20(6):706-717. PubMed PMID: 29984380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release. AU - Hughes,Melanie Hebe, AU - Prado,Héctor Juan, AU - Rodríguez,María Cecilia, AU - Michetti,Karina, AU - Leonardi,Patricia Inés, AU - Matulewicz,María Cristina, Y1 - 2018/07/09/ PY - 2017/12/18/received PY - 2018/06/12/accepted PY - 2018/7/10/pubmed PY - 2019/2/5/medline PY - 2018/7/10/entrez KW - Carrageenan KW - Controlled drug release KW - Gigartina skottsbergii KW - IPECs KW - Sarcothalia crispata SP - 706 EP - 717 JF - Marine biotechnology (New York, N.Y.) JO - Mar Biotechnol (NY) VL - 20 IS - 6 N2 - The aims of the present study were to characterize for the first time the carrageenan extracted from cystocarpic stage of S. crispata collected in the Patagonian coast of Argentina, and to prepare interpolyelectrolytic complexes (IPECs) between the polysaccharide extracted from cystocarpic stage of Sarcothalia crispata and Gigartina skottsbergii thalli, and basic butylated methacrylate copolymer (Eudragit E), in order to test their potential for the controlled release of ibuprofen as model drug. The structural determination revealed that the polysaccharides extracted from S. crispata and G. skottsbergii were mainly constituted by κ-carrageenan, particularly in the case of G. skottsbergii; however, significant amounts of ι- and ν-carrageenan were also detected in both polygalactans. The differences in diad composition and possibly in their distribution along the polysaccharide chain of both carrageenans would favor a different arrangement in the resulting IPEC structure. The smaller pores observed by scanning electron microscopy in the IPEC of S. crispata suggest that the kinks in the polysaccharide backbone are evenly distributed, resulting in a slower ibuprofen release compared to the IPEC of G. skottsbergii. SN - 1436-2236 UR - https://www.unboundmedicine.com/medline/citation/29984380/Carrageenans_from_Sarcothalia_crispata_and_Gigartina_skottsbergii:_Structural_Analysis_and_Interpolyelectrolyte_Complex_Formation_for_Drug_Controlled_Release_ L2 - https://scite.ai/reports/29984380 DB - PRIME DP - Unbound Medicine ER -