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Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic and gamma-linolenic acids.
Br J Nutr 1985; 53(3):449-58BJ

Abstract

Genetically diabetic mice (db/db) and their non-diabetic litter-mates were maintained for 15 weeks on diets supplemented with safflower oil or evening primrose (Oenothera bienis) oil, both essential fatty acid (EFA)-rich sources, or hydrogenated coconut oil (devoid of EFA). Plasma glucose was higher in the diabetic mice supplemented with the oils than in the unsupplemented diabetic mice. In the oil-supplemented non-diabetic mice, plasma glucose did not differ compared with the unsupplemented non-diabetic mice. The proportional content of arachidonic acid in the phospholipids of the pancreas was significantly decreased in diabetic mice, an effect which was completely prevented by supplementation with safflower or evening primrose oil but not hydrogenated coconut oil. In the liver phospholipids of the diabetic mice, dihomo-gamma-linolenic acid was proportionally increased, an effect reduced by supplementation with safflower oil but not evening primrose or hydrogenated coconut oils. In the liver triglycerides of the diabetic mice, gamma-linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid were all proportionally decreased, effects which were also prevented by safflower or evening primrose oil but not hydrogenated coconut oil. Alopecia and dry scaly skin were prominent in the diabetic mice but less extensive in the diabetic mice supplemented with EFA.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2998444

Citation

Cunnane, S C., et al. "Abnormal Essential Fatty Acid Composition of Tissue Lipids in Genetically Diabetic Mice Is Partially Corrected By Dietary Linoleic and Gamma-linolenic Acids." The British Journal of Nutrition, vol. 53, no. 3, 1985, pp. 449-58.
Cunnane SC, Manku MS, Horrobin DF. Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic and gamma-linolenic acids. Br J Nutr. 1985;53(3):449-58.
Cunnane, S. C., Manku, M. S., & Horrobin, D. F. (1985). Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic and gamma-linolenic acids. The British Journal of Nutrition, 53(3), pp. 449-58.
Cunnane SC, Manku MS, Horrobin DF. Abnormal Essential Fatty Acid Composition of Tissue Lipids in Genetically Diabetic Mice Is Partially Corrected By Dietary Linoleic and Gamma-linolenic Acids. Br J Nutr. 1985;53(3):449-58. PubMed PMID: 2998444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic and gamma-linolenic acids. AU - Cunnane,S C, AU - Manku,M S, AU - Horrobin,D F, PY - 1985/5/1/pubmed PY - 1985/5/1/medline PY - 1985/5/1/entrez SP - 449 EP - 58 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 53 IS - 3 N2 - Genetically diabetic mice (db/db) and their non-diabetic litter-mates were maintained for 15 weeks on diets supplemented with safflower oil or evening primrose (Oenothera bienis) oil, both essential fatty acid (EFA)-rich sources, or hydrogenated coconut oil (devoid of EFA). Plasma glucose was higher in the diabetic mice supplemented with the oils than in the unsupplemented diabetic mice. In the oil-supplemented non-diabetic mice, plasma glucose did not differ compared with the unsupplemented non-diabetic mice. The proportional content of arachidonic acid in the phospholipids of the pancreas was significantly decreased in diabetic mice, an effect which was completely prevented by supplementation with safflower or evening primrose oil but not hydrogenated coconut oil. In the liver phospholipids of the diabetic mice, dihomo-gamma-linolenic acid was proportionally increased, an effect reduced by supplementation with safflower oil but not evening primrose or hydrogenated coconut oils. In the liver triglycerides of the diabetic mice, gamma-linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid were all proportionally decreased, effects which were also prevented by safflower or evening primrose oil but not hydrogenated coconut oil. Alopecia and dry scaly skin were prominent in the diabetic mice but less extensive in the diabetic mice supplemented with EFA. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/2998444/Abnormal_essential_fatty_acid_composition_of_tissue_lipids_in_genetically_diabetic_mice_is_partially_corrected_by_dietary_linoleic_and_gamma_linolenic_acids_ L2 - https://medlineplus.gov/diabetes.html DB - PRIME DP - Unbound Medicine ER -