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Insulin and glucagon during the perinatal period: secretion and metabolic effects on the liver.
Biol Neonate 1985; 48(4):204-20BN

Abstract

Insulin and glucagon are detected in the plasma of most species early in gestation. In the fetus at term, insulin and glucagon secretion can be modified by long-term changes in glucose concentration but the responsiveness of A and B cells to glucose is lower than in the adult. The plasma insulin/glucagon molar ratio is high in the fetus at term, then decreases dramatically immediately after birth and remains low during the first hours of extrauterine life. This situation results in favored hepatic glycogen storage and prevented gluconeogenesis in utero, and sharp glycogen breakdown and active gluconeogenesis during the early postnatal period.

Authors

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Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

2998492

Citation

Ktorza, A, et al. "Insulin and Glucagon During the Perinatal Period: Secretion and Metabolic Effects On the Liver." Biology of the Neonate, vol. 48, no. 4, 1985, pp. 204-20.
Ktorza A, Bihoreau MT, Nurjhan N, et al. Insulin and glucagon during the perinatal period: secretion and metabolic effects on the liver. Biol Neonate. 1985;48(4):204-20.
Ktorza, A., Bihoreau, M. T., Nurjhan, N., Picon, L., & Girard, J. (1985). Insulin and glucagon during the perinatal period: secretion and metabolic effects on the liver. Biology of the Neonate, 48(4), pp. 204-20.
Ktorza A, et al. Insulin and Glucagon During the Perinatal Period: Secretion and Metabolic Effects On the Liver. Biol Neonate. 1985;48(4):204-20. PubMed PMID: 2998492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin and glucagon during the perinatal period: secretion and metabolic effects on the liver. AU - Ktorza,A, AU - Bihoreau,M T, AU - Nurjhan,N, AU - Picon,L, AU - Girard,J, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 204 EP - 20 JF - Biology of the neonate JO - Biol. Neonate VL - 48 IS - 4 N2 - Insulin and glucagon are detected in the plasma of most species early in gestation. In the fetus at term, insulin and glucagon secretion can be modified by long-term changes in glucose concentration but the responsiveness of A and B cells to glucose is lower than in the adult. The plasma insulin/glucagon molar ratio is high in the fetus at term, then decreases dramatically immediately after birth and remains low during the first hours of extrauterine life. This situation results in favored hepatic glycogen storage and prevented gluconeogenesis in utero, and sharp glycogen breakdown and active gluconeogenesis during the early postnatal period. SN - 0006-3126 UR - https://www.unboundmedicine.com/medline/citation/2998492/Insulin_and_glucagon_during_the_perinatal_period:_secretion_and_metabolic_effects_on_the_liver_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -