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Consumption of Coffee but Not of Other Caffeine-Containing Beverages Reduces the Risk of End-Stage Renal Disease in the Singapore Chinese Health Study.
J Nutr 2018; 148(8):1315-1322JN

Abstract

Background

Cross-sectional studies suggest that coffee drinking is associated with better renal function. However, to our knowledge, no prospective study has examined its relation with the risk of end-stage renal disease (ESRD).

Objective

We examined the relations between coffee, tea, soda, and total caffeine consumption and the risk of ESRD among middle-aged and older Chinese in Singapore.

Methods

We used data from the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women aged 45-74 y at recruitment from 1993 to 1998. Baseline information on the consumption of caffeinated coffee and other caffeinated beverages (tea and sodas), habitual diet, medical history, and lifestyle factors was obtained via in-person interviews. The standard serving size of 1 cup was assigned as 237 mL in the questionnaire. Incident ESRD cases were identified via linkage with the nationwide registry. We used multivariable Cox regression models to estimate HRs and 95% CIs of ESRD risk associated with the consumption of caffeinated beverages, with adjustment for potential confounders.

Results

After a mean follow-up of 16.8 y, 1143 cohort subjects developed ESRD. Compared with those who drank coffee less than daily, the HR (95% CI) was 0.91 (0.79, 1.05) for those who drank 1 cup of coffee/d and 0.82 (0.71, 0.96) for those who drank ≥2 cups/d (P-trend = 0.012). When stratified by sex, this association was observed in men but not in women. Compared with those who drank less than daily, the HR (95% CI) for drinking ≥2 cups/d was 0.71 (0.57, 0.87) among men and 0.97 (0.78, 1.19) among women (P-interaction = 0.03). Conversely, intakes of tea, soda, or total caffeine were not associated with the risk of ESRD in multivariable models.

Conclusion

The consumption of ≥2 cups of coffee/d may reduce the risk of ESRD in the general population, especially among men. This study was registered at http://www.clinicaltrials.gov as NCT03356340.

Authors+Show Affiliations

SingHealth Polyclinics, Singapore.Health Services and Systems Research, Duke-NUS Medical School Singapore, Singapore. Department of Renal Medicine, Singapore General Hospital, Singapore.National Registry of Diseases Office, Health Promotion Board, Singapore.Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA.Health Services and Systems Research, Duke-NUS Medical School Singapore, Singapore. Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29986029

Citation

Lew, Quan-Lan Jasmine, et al. "Consumption of Coffee but Not of Other Caffeine-Containing Beverages Reduces the Risk of End-Stage Renal Disease in the Singapore Chinese Health Study." The Journal of Nutrition, vol. 148, no. 8, 2018, pp. 1315-1322.
Lew QJ, Jafar TH, Jin A, et al. Consumption of Coffee but Not of Other Caffeine-Containing Beverages Reduces the Risk of End-Stage Renal Disease in the Singapore Chinese Health Study. J Nutr. 2018;148(8):1315-1322.
Lew, Q. J., Jafar, T. H., Jin, A., Yuan, J. M., & Koh, W. P. (2018). Consumption of Coffee but Not of Other Caffeine-Containing Beverages Reduces the Risk of End-Stage Renal Disease in the Singapore Chinese Health Study. The Journal of Nutrition, 148(8), pp. 1315-1322. doi:10.1093/jn/nxy075.
Lew QJ, et al. Consumption of Coffee but Not of Other Caffeine-Containing Beverages Reduces the Risk of End-Stage Renal Disease in the Singapore Chinese Health Study. J Nutr. 2018 08 1;148(8):1315-1322. PubMed PMID: 29986029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of Coffee but Not of Other Caffeine-Containing Beverages Reduces the Risk of End-Stage Renal Disease in the Singapore Chinese Health Study. AU - Lew,Quan-Lan Jasmine, AU - Jafar,Tazeen Hasan, AU - Jin,Aizhen, AU - Yuan,Jian-Min, AU - Koh,Woon-Puay, PY - 2017/12/06/received PY - 2018/03/23/accepted PY - 2018/7/10/pubmed PY - 2019/5/8/medline PY - 2018/7/10/entrez SP - 1315 EP - 1322 JF - The Journal of nutrition JO - J. Nutr. VL - 148 IS - 8 N2 - Background: Cross-sectional studies suggest that coffee drinking is associated with better renal function. However, to our knowledge, no prospective study has examined its relation with the risk of end-stage renal disease (ESRD). Objective: We examined the relations between coffee, tea, soda, and total caffeine consumption and the risk of ESRD among middle-aged and older Chinese in Singapore. Methods: We used data from the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women aged 45-74 y at recruitment from 1993 to 1998. Baseline information on the consumption of caffeinated coffee and other caffeinated beverages (tea and sodas), habitual diet, medical history, and lifestyle factors was obtained via in-person interviews. The standard serving size of 1 cup was assigned as 237 mL in the questionnaire. Incident ESRD cases were identified via linkage with the nationwide registry. We used multivariable Cox regression models to estimate HRs and 95% CIs of ESRD risk associated with the consumption of caffeinated beverages, with adjustment for potential confounders. Results: After a mean follow-up of 16.8 y, 1143 cohort subjects developed ESRD. Compared with those who drank coffee less than daily, the HR (95% CI) was 0.91 (0.79, 1.05) for those who drank 1 cup of coffee/d and 0.82 (0.71, 0.96) for those who drank ≥2 cups/d (P-trend = 0.012). When stratified by sex, this association was observed in men but not in women. Compared with those who drank less than daily, the HR (95% CI) for drinking ≥2 cups/d was 0.71 (0.57, 0.87) among men and 0.97 (0.78, 1.19) among women (P-interaction = 0.03). Conversely, intakes of tea, soda, or total caffeine were not associated with the risk of ESRD in multivariable models. Conclusion: The consumption of ≥2 cups of coffee/d may reduce the risk of ESRD in the general population, especially among men. This study was registered at http://www.clinicaltrials.gov as NCT03356340. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/29986029/Consumption_of_Coffee_but_Not_of_Other_Caffeine_Containing_Beverages_Reduces_the_Risk_of_End_Stage_Renal_Disease_in_the_Singapore_Chinese_Health_Study_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/nxy075 DB - PRIME DP - Unbound Medicine ER -