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Alcohol consumption and risk of gastric cardia adenocarcinoma and gastric noncardia adenocarcinoma: A 16-year prospective analysis from the NIH-AARP diet and health cohort.
Int J Cancer 2018; 143(11):2749-2757IJ

Abstract

The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We prospectively investigated the associations of alcohol consumption with gastric cardia adenocarcinoma (GCA) and gastric noncardia adenocarcinoma (GNCA) in 490,605 adults, aged 50-71 years at baseline who participated in the NIH-AARP diet and health study. Alcohol consumption in the past year was assessed at baseline by questionnaire and defined as total grams of ethanol intake per day or as a categorical variable: nondrinker, up to or including one drink per day, one to three drinks per day and greater than three drinks per day. We used multivariable-adjusted Cox proportional hazards regression to calculate the hazard ratios (HR) and 95% confidence intervals (CI) for associations between alcohol intake and risk of gastric adenocarcinomas. Through 2011, 662 incident cases of GCA and 713 of GNCA occurred. We found no association between higher alcohol consumption and GCA or GNCA, when examined as total alcoholic beverage intake or individual beverage types of beer, wine and liquor. Furthermore, we observed no association by stratum of sex, ethnic group, educational level or smoking status. We did, however, observe lower risk of GNCA among participants who drank up to one drink per day (HR = 0.81, 95% CI: 0.67-0.97) compared to nondrinkers. In conclusion, alcohol consumption was not associated with increased risk of GCA or GNCA in this large U.S. cohort.

Authors+Show Affiliations

National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.Biostatistics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

29992560

Citation

Wang, ShaoMing, et al. "Alcohol Consumption and Risk of Gastric Cardia Adenocarcinoma and Gastric Noncardia Adenocarcinoma: a 16-year Prospective Analysis From the NIH-AARP Diet and Health Cohort." International Journal of Cancer, vol. 143, no. 11, 2018, pp. 2749-2757.
Wang S, Freedman ND, Loftfield E, et al. Alcohol consumption and risk of gastric cardia adenocarcinoma and gastric noncardia adenocarcinoma: A 16-year prospective analysis from the NIH-AARP diet and health cohort. Int J Cancer. 2018;143(11):2749-2757.
Wang, S., Freedman, N. D., Loftfield, E., Hua, X., & Abnet, C. C. (2018). Alcohol consumption and risk of gastric cardia adenocarcinoma and gastric noncardia adenocarcinoma: A 16-year prospective analysis from the NIH-AARP diet and health cohort. International Journal of Cancer, 143(11), pp. 2749-2757. doi:10.1002/ijc.31740.
Wang S, et al. Alcohol Consumption and Risk of Gastric Cardia Adenocarcinoma and Gastric Noncardia Adenocarcinoma: a 16-year Prospective Analysis From the NIH-AARP Diet and Health Cohort. Int J Cancer. 2018 12 1;143(11):2749-2757. PubMed PMID: 29992560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and risk of gastric cardia adenocarcinoma and gastric noncardia adenocarcinoma: A 16-year prospective analysis from the NIH-AARP diet and health cohort. AU - Wang,ShaoMing, AU - Freedman,Neal D, AU - Loftfield,Erikka, AU - Hua,Xing, AU - Abnet,Christian C, Y1 - 2018/10/09/ PY - 2018/03/20/received PY - 2018/05/30/revised PY - 2018/06/21/accepted PY - 2018/7/12/pubmed PY - 2019/3/21/medline PY - 2018/7/12/entrez KW - NIH-AARP KW - alcohol KW - gastric cardia adenocarcinoma KW - gastric noncardia adenocarcinoma KW - prospective analysis SP - 2749 EP - 2757 JF - International journal of cancer JO - Int. J. Cancer VL - 143 IS - 11 N2 - The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We prospectively investigated the associations of alcohol consumption with gastric cardia adenocarcinoma (GCA) and gastric noncardia adenocarcinoma (GNCA) in 490,605 adults, aged 50-71 years at baseline who participated in the NIH-AARP diet and health study. Alcohol consumption in the past year was assessed at baseline by questionnaire and defined as total grams of ethanol intake per day or as a categorical variable: nondrinker, up to or including one drink per day, one to three drinks per day and greater than three drinks per day. We used multivariable-adjusted Cox proportional hazards regression to calculate the hazard ratios (HR) and 95% confidence intervals (CI) for associations between alcohol intake and risk of gastric adenocarcinomas. Through 2011, 662 incident cases of GCA and 713 of GNCA occurred. We found no association between higher alcohol consumption and GCA or GNCA, when examined as total alcoholic beverage intake or individual beverage types of beer, wine and liquor. Furthermore, we observed no association by stratum of sex, ethnic group, educational level or smoking status. We did, however, observe lower risk of GNCA among participants who drank up to one drink per day (HR = 0.81, 95% CI: 0.67-0.97) compared to nondrinkers. In conclusion, alcohol consumption was not associated with increased risk of GCA or GNCA in this large U.S. cohort. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/29992560/Alcohol_consumption_and_risk_of_gastric_cardia_adenocarcinoma_and_gastric_noncardia_adenocarcinoma:_A_16_year_prospective_analysis_from_the_NIH_AARP_diet_and_health_cohort_ L2 - https://doi.org/10.1002/ijc.31740 DB - PRIME DP - Unbound Medicine ER -