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Visual function and inner retinal structure correlations in aquaporin-4 antibody-positive optic neuritis.
Jpn J Ophthalmol. 2018 Sep; 62(5):598-604.JJ

Abstract

PURPOSE

To investigate the correlation between visual function and thinning of the retinal nerve fiber layer (RNFL) and the macular ganglion cell-inner plexiform layer (GCIPL) as measured by optical coherence tomography (OCT) in eyes with aquaporin-4 IgG-positive optic neuritis (AQP4-IgG-positive ON).

STUDY DESIGN

Prospective study.

METHODS

Patients with a history of ON were categorized into 2 groups: the AQP4-IgG-positive group and the AQP4-IgG-negative group. Patients with multiple sclerosis were excluded. All patients underwent ophthalmologic examination and OCT imaging at least 6 months after the last episode of acute ON. Visual function and inner retinal structure correlations were analyzed using Pearson correlation and regression analyses.

RESULTS

Thirty-one previous ON eyes of 17 AQP4-IgG-positive patients and 21 previous ON eyes of 15 AQP4-IgG-negative patients were registered. Visual function, especially the visual field, was better correlated with RNFL than with macular GCIPL. The best correlation between visual function and RNFL was the linear model, whereas the best correlation between visual function and GCIPL was the nonlinear model (inverse regression). Regression models revealed worse visual function in AQP4-IgG-positive ON than in AQP4-IgG-negative ON, whereas no differences in RNFL and GCIPL were found between the 2 groups.

CONCLUSIONS

RNFL measured by OCT can be a useful retinal structure for estimating and monitoring visual field loss in AQP4-IgG-positive ON patients, particularly in patients whose visual field cannot be quantitated. The correlation between visual function and the inner retinal structure of eyes with AQP4-IgG is unique and differs from that of eyes without AQP4-IgG.

Authors+Show Affiliations

Department of Ophthalmology, Naresuan University Hospital, Naresuan University, Phitsanulok, Thailand.Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. niphon.chi@mahidol.ac.th.Department of Ophthalmology, Mettapracharak Hospital, Nakhon Pathom, Thailand.Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Bumrungrad International Hospital, Bangkok, Thailand.Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Bangkok Hospital Headquarters, BDMS, Bangkok, Thailand.Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29995195

Citation

Mekhasingharak, Nattapong, et al. "Visual Function and Inner Retinal Structure Correlations in Aquaporin-4 Antibody-positive Optic Neuritis." Japanese Journal of Ophthalmology, vol. 62, no. 5, 2018, pp. 598-604.
Mekhasingharak N, Chirapapaisan N, Laowanapiban P, et al. Visual function and inner retinal structure correlations in aquaporin-4 antibody-positive optic neuritis. Jpn J Ophthalmol. 2018;62(5):598-604.
Mekhasingharak, N., Chirapapaisan, N., Laowanapiban, P., Siritho, S., Prayoonwiwat, N., Satukijchai, C., Jitprapaikulsan, J., & Mekhasingharak, P. (2018). Visual function and inner retinal structure correlations in aquaporin-4 antibody-positive optic neuritis. Japanese Journal of Ophthalmology, 62(5), 598-604. https://doi.org/10.1007/s10384-018-0607-4
Mekhasingharak N, et al. Visual Function and Inner Retinal Structure Correlations in Aquaporin-4 Antibody-positive Optic Neuritis. Jpn J Ophthalmol. 2018;62(5):598-604. PubMed PMID: 29995195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visual function and inner retinal structure correlations in aquaporin-4 antibody-positive optic neuritis. AU - Mekhasingharak,Nattapong, AU - Chirapapaisan,Niphon, AU - Laowanapiban,Poramaet, AU - Siritho,Sasitorn, AU - Prayoonwiwat,Naraporn, AU - Satukijchai,Chanjira, AU - Jitprapaikulsan,Jiraporn, AU - Mekhasingharak,Pornsawan, AU - ,, Y1 - 2018/07/11/ PY - 2017/11/19/received PY - 2018/05/14/accepted PY - 2018/7/12/pubmed PY - 2019/3/22/medline PY - 2018/7/12/entrez KW - Aquaporin-4 antibody KW - Neuromyelitis optica KW - Optic neuritis KW - Optical coherence tomography KW - Visual function SP - 598 EP - 604 JF - Japanese journal of ophthalmology JO - Jpn. J. Ophthalmol. VL - 62 IS - 5 N2 - PURPOSE: To investigate the correlation between visual function and thinning of the retinal nerve fiber layer (RNFL) and the macular ganglion cell-inner plexiform layer (GCIPL) as measured by optical coherence tomography (OCT) in eyes with aquaporin-4 IgG-positive optic neuritis (AQP4-IgG-positive ON). STUDY DESIGN: Prospective study. METHODS: Patients with a history of ON were categorized into 2 groups: the AQP4-IgG-positive group and the AQP4-IgG-negative group. Patients with multiple sclerosis were excluded. All patients underwent ophthalmologic examination and OCT imaging at least 6 months after the last episode of acute ON. Visual function and inner retinal structure correlations were analyzed using Pearson correlation and regression analyses. RESULTS: Thirty-one previous ON eyes of 17 AQP4-IgG-positive patients and 21 previous ON eyes of 15 AQP4-IgG-negative patients were registered. Visual function, especially the visual field, was better correlated with RNFL than with macular GCIPL. The best correlation between visual function and RNFL was the linear model, whereas the best correlation between visual function and GCIPL was the nonlinear model (inverse regression). Regression models revealed worse visual function in AQP4-IgG-positive ON than in AQP4-IgG-negative ON, whereas no differences in RNFL and GCIPL were found between the 2 groups. CONCLUSIONS: RNFL measured by OCT can be a useful retinal structure for estimating and monitoring visual field loss in AQP4-IgG-positive ON patients, particularly in patients whose visual field cannot be quantitated. The correlation between visual function and the inner retinal structure of eyes with AQP4-IgG is unique and differs from that of eyes without AQP4-IgG. SN - 1613-2246 UR - https://www.unboundmedicine.com/medline/citation/29995195/Visual_function_and_inner_retinal_structure_correlations_in_aquaporin_4_antibody_positive_optic_neuritis_ L2 - https://dx.doi.org/10.1007/s10384-018-0607-4 DB - PRIME DP - Unbound Medicine ER -