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Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome.
Am J Physiol Gastrointest Liver Physiol. 2018 11 01; 315(5):G651-G658.AJ

Abstract

Improved understanding of neuroimmune communication and the neural regulation of immunity and inflammation has recently led to proposing the concept of the "neuroimmune communicatome." This advance is based on experimental evidence for an organized and brain-integrated reflex-like relationship and dialogue between the nervous and the immune systems. A key circuitry in this communicatome is provided by efferent vagus nerve fibers and cholinergic signaling. Inflammation and metabolic alterations coexist in many disorders affecting the liver and the gastrointestinal (GI) tract, including obesity, metabolic syndrome, fatty liver disease, liver injury, and liver failure, as well as inflammatory bowel disease. Here, we outline mechanistic insights regarding the role of the vagus nerve and cholinergic signaling in the regulation of inflammation linked to metabolic derangements and the pathogenesis of these disorders in preclinical settings. Recent clinical advances using this knowledge in novel therapeutic neuromodulatory approaches within the field of bioelectronic medicine are also briefly summarized.

Authors+Show Affiliations

Center for Biomedical Science and Bioelectronic Medicine, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell , Hempstead, New York.Center for Biomedical Science and Bioelectronic Medicine, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell , Hempstead, New York.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

30001146

Citation

Metz, Christine N., and Valentin A. Pavlov. "Vagus Nerve Cholinergic Circuitry to the Liver and the Gastrointestinal Tract in the Neuroimmune Communicatome." American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 315, no. 5, 2018, pp. G651-G658.
Metz CN, Pavlov VA. Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome. Am J Physiol Gastrointest Liver Physiol. 2018;315(5):G651-G658.
Metz, C. N., & Pavlov, V. A. (2018). Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome. American Journal of Physiology. Gastrointestinal and Liver Physiology, 315(5), G651-G658. https://doi.org/10.1152/ajpgi.00195.2018
Metz CN, Pavlov VA. Vagus Nerve Cholinergic Circuitry to the Liver and the Gastrointestinal Tract in the Neuroimmune Communicatome. Am J Physiol Gastrointest Liver Physiol. 2018 11 1;315(5):G651-G658. PubMed PMID: 30001146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome. AU - Metz,Christine N, AU - Pavlov,Valentin A, Y1 - 2018/07/12/ PY - 2018/7/13/pubmed PY - 2019/8/17/medline PY - 2018/7/13/entrez KW - GI tract KW - cholinergic KW - inflammation KW - liver KW - vagus SP - G651 EP - G658 JF - American journal of physiology. Gastrointestinal and liver physiology JO - Am J Physiol Gastrointest Liver Physiol VL - 315 IS - 5 N2 - Improved understanding of neuroimmune communication and the neural regulation of immunity and inflammation has recently led to proposing the concept of the "neuroimmune communicatome." This advance is based on experimental evidence for an organized and brain-integrated reflex-like relationship and dialogue between the nervous and the immune systems. A key circuitry in this communicatome is provided by efferent vagus nerve fibers and cholinergic signaling. Inflammation and metabolic alterations coexist in many disorders affecting the liver and the gastrointestinal (GI) tract, including obesity, metabolic syndrome, fatty liver disease, liver injury, and liver failure, as well as inflammatory bowel disease. Here, we outline mechanistic insights regarding the role of the vagus nerve and cholinergic signaling in the regulation of inflammation linked to metabolic derangements and the pathogenesis of these disorders in preclinical settings. Recent clinical advances using this knowledge in novel therapeutic neuromodulatory approaches within the field of bioelectronic medicine are also briefly summarized. SN - 1522-1547 UR - https://www.unboundmedicine.com/medline/citation/30001146/Vagus_nerve_cholinergic_circuitry_to_the_liver_and_the_gastrointestinal_tract_in_the_neuroimmune_communicatome_ L2 - https://journals.physiology.org/doi/10.1152/ajpgi.00195.2018?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -