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Ultrasound/CT combined with serum CEA/CA19.9 in the diagnosis and prognosis of rectal cancer.
J BUON. 2018 May-Jun; 23(3):592-597.JB

Abstract

PURPOSE

To explore the significance of computed tomography (CT) and transrectal ultrasonography (TRUS) combined with serum CEA and CA19.9 in the staging, diagnosis and prognosis of rectal cancer.

METHODS

Fifty-six patients with rectal cancer were recruited from our oncology department. ELISA detected the expression level of CEA and CA19.9 in serum. The hemodynamic parameters of the rectal mucosa and tumor were detected by TRUS [resistance index (RI), pulse index (PI), peak systolic velocity (PSV), end-diastolic volume (EDV)]. All patients were pathologically examined to determine the disease stage and to compare the diagnostic accuracy of serum tumor markers, CT and TRUS. All patients were followed up for 24 months to assess the relationship between the combined examinations and the disease prognosis.

RESULTS

CEA and CA19.9 levels were significantly different in patients with different pathological stages (p<0.05). RI and PI decreased with increasing pathological stage, while PSV and EDV were increased with increasing pathological stage. The serum CEA+CA19.9 examination showed 12 cases of misdiagnosis, with an accuracy diagnostic rate of 78.57% (447sol;56). CT examination showed 8 cases of misdiagnosis, with an accuracy diagnostic rate of 85.71% (48/56). TRUS showed 6 cases of misdiagnosis, with an accuracy diagnostic rate of 89.28% (50/56). However, only 2 cases were misdiagnosed and 96.43% (54/56) were accurate, while no statistical difference was noticed between combined detection and pathology (p<0.05). Postoperative follow-up showed significant differences in T staging at 6 months, 1 year and 2 years after operation (p<0.05).

CONCLUSION

CT and TRUS combined with serum CEA and CA19.9 had great value in the diagnosis and prognosis in rectal cancer.

Authors+Show Affiliations

Department of Ultrasonography, Τhe Second People's Hospital of Liaocheng, Liaocheng, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30003724

Citation

Zhang, Beibei, et al. "Ultrasound/CT Combined With Serum CEA/CA19.9 in the Diagnosis and Prognosis of Rectal Cancer." Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology, vol. 23, no. 3, 2018, pp. 592-597.
Zhang B, Sun Z, Song M, et al. Ultrasound/CT combined with serum CEA/CA19.9 in the diagnosis and prognosis of rectal cancer. J BUON. 2018;23(3):592-597.
Zhang, B., Sun, Z., Song, M., Ma, S., Tian, Y., & Kong, Q. (2018). Ultrasound/CT combined with serum CEA/CA19.9 in the diagnosis and prognosis of rectal cancer. Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology, 23(3), 592-597.
Zhang B, et al. Ultrasound/CT Combined With Serum CEA/CA19.9 in the Diagnosis and Prognosis of Rectal Cancer. J BUON. 2018 May-Jun;23(3):592-597. PubMed PMID: 30003724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrasound/CT combined with serum CEA/CA19.9 in the diagnosis and prognosis of rectal cancer. AU - Zhang,Beibei, AU - Sun,Zhenzhong, AU - Song,Min, AU - Ma,Suqiao, AU - Tian,Yujing, AU - Kong,Qingfeng, PY - 2018/7/14/entrez PY - 2018/7/14/pubmed PY - 2019/9/24/medline SP - 592 EP - 597 JF - Journal of B.U.ON. : official journal of the Balkan Union of Oncology JO - J BUON VL - 23 IS - 3 N2 - PURPOSE: To explore the significance of computed tomography (CT) and transrectal ultrasonography (TRUS) combined with serum CEA and CA19.9 in the staging, diagnosis and prognosis of rectal cancer. METHODS: Fifty-six patients with rectal cancer were recruited from our oncology department. ELISA detected the expression level of CEA and CA19.9 in serum. The hemodynamic parameters of the rectal mucosa and tumor were detected by TRUS [resistance index (RI), pulse index (PI), peak systolic velocity (PSV), end-diastolic volume (EDV)]. All patients were pathologically examined to determine the disease stage and to compare the diagnostic accuracy of serum tumor markers, CT and TRUS. All patients were followed up for 24 months to assess the relationship between the combined examinations and the disease prognosis. RESULTS: CEA and CA19.9 levels were significantly different in patients with different pathological stages (p<0.05). RI and PI decreased with increasing pathological stage, while PSV and EDV were increased with increasing pathological stage. The serum CEA+CA19.9 examination showed 12 cases of misdiagnosis, with an accuracy diagnostic rate of 78.57% (447sol;56). CT examination showed 8 cases of misdiagnosis, with an accuracy diagnostic rate of 85.71% (48/56). TRUS showed 6 cases of misdiagnosis, with an accuracy diagnostic rate of 89.28% (50/56). However, only 2 cases were misdiagnosed and 96.43% (54/56) were accurate, while no statistical difference was noticed between combined detection and pathology (p<0.05). Postoperative follow-up showed significant differences in T staging at 6 months, 1 year and 2 years after operation (p<0.05). CONCLUSION: CT and TRUS combined with serum CEA and CA19.9 had great value in the diagnosis and prognosis in rectal cancer. SN - 1107-0625 UR - https://www.unboundmedicine.com/medline/citation/30003724/Ultrasound/CT_combined_with_serum_CEA/CA19_9_in_the_diagnosis_and_prognosis_of_rectal_cancer_ L2 - https://www.jbuon.com/archive/23-3-592.pdf DB - PRIME DP - Unbound Medicine ER -