Tags

Type your tag names separated by a space and hit enter

Phoneutria nigriventer venom: A pharmacological treasure.
Toxicon. 2018 Sep 01; 151:96-110.T

Abstract

In millions of years, spiders have optimized their venoms in order to assure successful prey capture and defence against predators. Spider venoms have become unique cocktails of biological active components enabling potentially interesting application for drug discovery or for agricultural purposes. The venom of Phoneutria nigriventer has been studied for over 60 years. This spider is responsible for a high number of envenomations with severe clinical manifestations in humans, which necessitates a comprehensive knowledge of its venom composition. With over 40 different neurotoxic peptides characterized so far and still many more awaiting identification, this venom is undoubtedly a pharmacological treasure. This review provides an overview of the Phoneutria nigriventer toxins known today and describes their mechanism of action at a molecular level. We critically discuss the potential of the Phoneutria nigriventer venom peptides as pharmaceutical tools or lead compounds for drug development.

Authors+Show Affiliations

Toxicology and Pharmacology, University of Leuven (KU Leuven), Campus Gasthuisberg, PO Box 922, Herestraat 49, 3000 Leuven, Belgium; Laboratório de Venenos e Toxinas Animais, Dept de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901, Belo-Horizonte, MG, Brazil.Laboratório de Venenos e Toxinas Animais, Dept de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901, Belo-Horizonte, MG, Brazil; Programa de Pós-graduação em Ciências da Saúde, Biomedicina e Medicina, Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte, Grupo Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil. Electronic address: lima.mariaelena@gmail.com.Toxicology and Pharmacology, University of Leuven (KU Leuven), Campus Gasthuisberg, PO Box 922, Herestraat 49, 3000 Leuven, Belgium. Electronic address: jan.tytgat@kuleuven.be.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30003916

Citation

Peigneur, Steve, et al. "Phoneutria Nigriventer Venom: a Pharmacological Treasure." Toxicon : Official Journal of the International Society On Toxinology, vol. 151, 2018, pp. 96-110.
Peigneur S, de Lima ME, Tytgat J. Phoneutria nigriventer venom: A pharmacological treasure. Toxicon. 2018;151:96-110.
Peigneur, S., de Lima, M. E., & Tytgat, J. (2018). Phoneutria nigriventer venom: A pharmacological treasure. Toxicon : Official Journal of the International Society On Toxinology, 151, 96-110. https://doi.org/10.1016/j.toxicon.2018.07.008
Peigneur S, de Lima ME, Tytgat J. Phoneutria Nigriventer Venom: a Pharmacological Treasure. Toxicon. 2018 Sep 1;151:96-110. PubMed PMID: 30003916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phoneutria nigriventer venom: A pharmacological treasure. AU - Peigneur,Steve, AU - de Lima,Maria Elena, AU - Tytgat,Jan, Y1 - 2018/07/10/ PY - 2018/02/28/received PY - 2018/06/27/revised PY - 2018/07/05/accepted PY - 2018/7/14/pubmed PY - 2018/12/12/medline PY - 2018/7/14/entrez SP - 96 EP - 110 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 151 N2 - In millions of years, spiders have optimized their venoms in order to assure successful prey capture and defence against predators. Spider venoms have become unique cocktails of biological active components enabling potentially interesting application for drug discovery or for agricultural purposes. The venom of Phoneutria nigriventer has been studied for over 60 years. This spider is responsible for a high number of envenomations with severe clinical manifestations in humans, which necessitates a comprehensive knowledge of its venom composition. With over 40 different neurotoxic peptides characterized so far and still many more awaiting identification, this venom is undoubtedly a pharmacological treasure. This review provides an overview of the Phoneutria nigriventer toxins known today and describes their mechanism of action at a molecular level. We critically discuss the potential of the Phoneutria nigriventer venom peptides as pharmaceutical tools or lead compounds for drug development. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/30003916/Phoneutria_nigriventer_venom:_A_pharmacological_treasure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(18)30304-0 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.