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Histopathological differences between primary Sjögren's syndrome and Sjögren's syndrome accompanied by scleroderma.
Indian J Pathol Microbiol. 2018 Jul-Sep; 61(3):319-322.IJ

Abstract

Background

Investigation of morphological differences in relation with serological variables between primary versus secondary Sjögren's syndrome associated with systemic scleroderma (Scl-SS).

Materials and Methods

A total of 69 primary Sjögren's syndrome (pSS) and Scl-SS patients were grouped according to the American-European Consensus Group criteria. Serum autoantibody information was obtained from the patient records. Hematoxylin and eosin sections of the minor salivary gland biopsy were reevaluated, and the lymphocyte focus score (FS), plasma cell focus, and fibrosis rates were all evaluated.

Results

There were 43 pSS and 26 Scl-SS cases. Both biopsy and autoantibody were positive in 16 pSS cases while only biopsy was positive in 25 cases and only antibody in 1 case. Both biopsy and antibody were positive in 5 Scl-SS cases while only biopsy was positive in 18 and only antibody in 3 cases. The plasma cell focus was statistically significantly higher in pSS cases (P = 0.003). No difference was seen between Sjögren' syndrome (SS) subtypes in terms of lymphocyte FS, fibrosis, and autoantibody positivity.

Conclusion

We found that plasma cell focuses could be found more frequently in pSS than Scl-SS. In addition, our study reveals that the coexistence of SS and systemic scleroderma decreases the incidence of FS value ≥1 compared to pSS.

Authors+Show Affiliations

Department of Pathology, Tepecik Research and Training Hospital, Izmir, Turkey.Department of Pathology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.Department of Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.Department of Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.Department of Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30004047

Citation

Kucuk, Ulku, et al. "Histopathological Differences Between Primary Sjögren's Syndrome and Sjögren's Syndrome Accompanied By Scleroderma." Indian Journal of Pathology & Microbiology, vol. 61, no. 3, 2018, pp. 319-322.
Kucuk U, Sarioglu S, Cetin P, et al. Histopathological differences between primary Sjögren's syndrome and Sjögren's syndrome accompanied by scleroderma. Indian J Pathol Microbiol. 2018;61(3):319-322.
Kucuk, U., Sarioglu, S., Cetin, P., Sari, I., & Birlik, M. (2018). Histopathological differences between primary Sjögren's syndrome and Sjögren's syndrome accompanied by scleroderma. Indian Journal of Pathology & Microbiology, 61(3), 319-322. https://doi.org/10.4103/IJPM.IJPM_416_17
Kucuk U, et al. Histopathological Differences Between Primary Sjögren's Syndrome and Sjögren's Syndrome Accompanied By Scleroderma. Indian J Pathol Microbiol. 2018 Jul-Sep;61(3):319-322. PubMed PMID: 30004047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histopathological differences between primary Sjögren's syndrome and Sjögren's syndrome accompanied by scleroderma. AU - Kucuk,Ulku, AU - Sarioglu,Sulen, AU - Cetin,Pinar, AU - Sari,Ismail, AU - Birlik,Merih, PY - 2018/7/14/entrez PY - 2018/7/14/pubmed PY - 2018/11/22/medline KW - Differences KW - Sjögren's syndrome KW - histopathological KW - scleroderma SP - 319 EP - 322 JF - Indian journal of pathology & microbiology JO - Indian J Pathol Microbiol VL - 61 IS - 3 N2 - Background: Investigation of morphological differences in relation with serological variables between primary versus secondary Sjögren's syndrome associated with systemic scleroderma (Scl-SS). Materials and Methods: A total of 69 primary Sjögren's syndrome (pSS) and Scl-SS patients were grouped according to the American-European Consensus Group criteria. Serum autoantibody information was obtained from the patient records. Hematoxylin and eosin sections of the minor salivary gland biopsy were reevaluated, and the lymphocyte focus score (FS), plasma cell focus, and fibrosis rates were all evaluated. Results: There were 43 pSS and 26 Scl-SS cases. Both biopsy and autoantibody were positive in 16 pSS cases while only biopsy was positive in 25 cases and only antibody in 1 case. Both biopsy and antibody were positive in 5 Scl-SS cases while only biopsy was positive in 18 and only antibody in 3 cases. The plasma cell focus was statistically significantly higher in pSS cases (P = 0.003). No difference was seen between Sjögren' syndrome (SS) subtypes in terms of lymphocyte FS, fibrosis, and autoantibody positivity. Conclusion: We found that plasma cell focuses could be found more frequently in pSS than Scl-SS. In addition, our study reveals that the coexistence of SS and systemic scleroderma decreases the incidence of FS value ≥1 compared to pSS. SN - 0974-5130 UR - https://www.unboundmedicine.com/medline/citation/30004047/Histopathological_differences_between_primary_Sjögren's_syndrome_and_Sjögren's_syndrome_accompanied_by_scleroderma_ L2 - http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=3;spage=319;epage=322;aulast=Kucuk DB - PRIME DP - Unbound Medicine ER -