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Acute idiopathic optic neuritis: not always benign.
Eur J Neurol 2018; 25(11):1378-1383EJ

Abstract

BACKGROUND AND PURPOSE

Few recent data are available concerning idiopathic optic neuritis (ON). We aimed to describe a large cohort of patients with idiopathic ON. We compared this cohort with patients with ON related to myelin oligodendrocyte glycoprotein (MOG) or ON related to aquaporin-4 (AQP4) antibodies.

METHODS

This was a monocentric retrospective observational study. Inclusion criteria for idiopathic ON were as follows: age ≥ 16 years, follow-up of at least 2 years, negative for antibodies against MOG and AQP4 immunoglobulin G, and no magnetic resonance imaging (MRI) lesions suggestive of demyelination (two brain MRI scans, one at baseline and one during follow-up, and one spinal cord MRI scan).

RESULTS

Among 23 patients with idiopathic ON (female, 82.6%; median age, 36 years; median follow-up time, 41.4 months), 56.5% had recurrent ON (median time to a second ON episode, 6 months). The final visual acuity in this group (median, 0; mean, 0.43; range, 0-3) was similar to that in the AQP4 group (n = 18; P-value after Bonferroni correction = 0.936) but worse than that in the MOG group (n = 25; P-value after Bonferroni correction = 0.019). At the last evaluation, visual acuity levels were ≤0.5 and <0.2, respectively, in 36.8% and 21% of the idiopathic ON group, 58.3% and 26.7% of the AQP4 group, and 0% and 0% of the MOG group.

CONCLUSION

The recovery of visual acuity among patients with idiopathic ON was poor, similar to that observed in the AQP4 group.

Authors+Show Affiliations

Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Radiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Neuro-Ophthalmolology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Neurology, Hospices civils de Lyon, Hôpital neurologique Pierre Wertheimer, Lyon, France.Department of Neuro-Ophthalmolology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

30004610

Citation

Deschamps, R, et al. "Acute Idiopathic Optic Neuritis: Not Always Benign." European Journal of Neurology, vol. 25, no. 11, 2018, pp. 1378-1383.
Deschamps R, Gueguen A, Lecler A, et al. Acute idiopathic optic neuritis: not always benign. Eur J Neurol. 2018;25(11):1378-1383.
Deschamps, R., Gueguen, A., Lecler, A., Lecouturier, K., Lamirel, C., Bensa, C., ... Gout, O. (2018). Acute idiopathic optic neuritis: not always benign. European Journal of Neurology, 25(11), pp. 1378-1383. doi:10.1111/ene.13753.
Deschamps R, et al. Acute Idiopathic Optic Neuritis: Not Always Benign. Eur J Neurol. 2018;25(11):1378-1383. PubMed PMID: 30004610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute idiopathic optic neuritis: not always benign. AU - Deschamps,R, AU - Gueguen,A, AU - Lecler,A, AU - Lecouturier,K, AU - Lamirel,C, AU - Bensa,C, AU - Marignier,R, AU - Vignal,C, AU - Gout,O, Y1 - 2018/08/16/ PY - 2018/03/21/received PY - 2018/07/10/accepted PY - 2018/7/14/pubmed PY - 2019/4/17/medline PY - 2018/7/14/entrez KW - anti-aquaporin-4 KW - idiopathic KW - myelin oligodendrocyte glycoprotein KW - neuromyelitis optica KW - optic neuritis SP - 1378 EP - 1383 JF - European journal of neurology JO - Eur. J. Neurol. VL - 25 IS - 11 N2 - BACKGROUND AND PURPOSE: Few recent data are available concerning idiopathic optic neuritis (ON). We aimed to describe a large cohort of patients with idiopathic ON. We compared this cohort with patients with ON related to myelin oligodendrocyte glycoprotein (MOG) or ON related to aquaporin-4 (AQP4) antibodies. METHODS: This was a monocentric retrospective observational study. Inclusion criteria for idiopathic ON were as follows: age ≥ 16 years, follow-up of at least 2 years, negative for antibodies against MOG and AQP4 immunoglobulin G, and no magnetic resonance imaging (MRI) lesions suggestive of demyelination (two brain MRI scans, one at baseline and one during follow-up, and one spinal cord MRI scan). RESULTS: Among 23 patients with idiopathic ON (female, 82.6%; median age, 36 years; median follow-up time, 41.4 months), 56.5% had recurrent ON (median time to a second ON episode, 6 months). The final visual acuity in this group (median, 0; mean, 0.43; range, 0-3) was similar to that in the AQP4 group (n = 18; P-value after Bonferroni correction = 0.936) but worse than that in the MOG group (n = 25; P-value after Bonferroni correction = 0.019). At the last evaluation, visual acuity levels were ≤0.5 and <0.2, respectively, in 36.8% and 21% of the idiopathic ON group, 58.3% and 26.7% of the AQP4 group, and 0% and 0% of the MOG group. CONCLUSION: The recovery of visual acuity among patients with idiopathic ON was poor, similar to that observed in the AQP4 group. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/30004610/Acute_idiopathic_optic_neuritis:_not_always_benign_ L2 - https://doi.org/10.1111/ene.13753 DB - PRIME DP - Unbound Medicine ER -