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The association between alcohol consumption and risk of hip fracture differs by age and gender in Cohort of Norway: a NOREPOS study.
Osteoporos Int. 2018 Nov; 29(11):2457-2467.OI

Abstract

The association between alcohol consumption and hip fracture differed by gender: Men aged 30-59 years drinking frequently or 14+ gl/week had higher risk than moderate drinkers. No significant association was seen in older men. Women not drinking alcohol had higher risk than those drinking moderately both regarding frequency and amount.

INTRODUCTION

We aimed to examine alcohol consumption and risk of hip fracture according to age and gender in the population-based Cohort of Norway (1994-2003).

METHODS

Socio-demographics, lifestyle, and health were self-reported and weight and height were measured in 70,568 men and 71,357 women ≥ 30 years. Information on subsequent hip fractures was retrieved from hospitals' electronic patient registries during 1994-2013. Frequency of alcohol consumption was categorized: never/seldom, moderate (≤ 2-3 times/week), or frequent (≥ 4 times/week), and amount as number of glasses per week: 0, 1-6, 7-13, 14-27, and 28+. Type of alcohol (wine vs. beer/hard liquor) was also examined. Cox's proportional hazards regression was used to estimate hazard ratios (HRs) stratified on gender and baseline age < 60 and ≥ 60 years.

RESULTS

During median 15-year follow-up, 1558 men and 2511 women suffered a hip fracture. Using moderate drinkers as reference, men < 60 years drinking frequently had multivariable adjusted HR = 1.73 (CI 1.02-2.96) for hip fracture and more than 2.5 times higher risk if they consumed 14+ glasses compared to 1-6 glasses per week. In other groups of age and gender, no statistically significant increased risk was found in those consuming the highest levels of alcohol. Compared to women with moderate or frequent alcohol use, never/seldom-drinking women had the highest fracture risk. In women, use of wine was associated with lower fracture risk than other types of alcohol.

CONCLUSIONS

Risk of hip fracture was highest in men < 60 years with the highest frequency and amount of alcohol consumption and in non-drinking women.

Authors+Show Affiliations

Division of Mental and Physical Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Oslo, Norway. anne.johanne.sogaard@fhi.no.Division of Mental and Physical Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Oslo, Norway. Department of Clinical Science, University of Bergen, Bergen, Norway.Division of Mental and Physical Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Oslo, Norway. Institute of Health and Society, University of Oslo, Oslo, Norway.Institute of Health and Society, University of Oslo, Oslo, Norway.Division of Mental and Physical Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Oslo, Norway.Division of Mental and Physical Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Oslo, Norway. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.Division of Mental and Physical Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Oslo, Norway.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30006884

Citation

Søgaard, A J., et al. "The Association Between Alcohol Consumption and Risk of Hip Fracture Differs By Age and Gender in Cohort of Norway: a NOREPOS Study." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 29, no. 11, 2018, pp. 2457-2467.
Søgaard AJ, Ranhoff AH, Meyer HE, et al. The association between alcohol consumption and risk of hip fracture differs by age and gender in Cohort of Norway: a NOREPOS study. Osteoporos Int. 2018;29(11):2457-2467.
Søgaard, A. J., Ranhoff, A. H., Meyer, H. E., Omsland, T. K., Nystad, W., Tell, G. S., & Holvik, K. (2018). The association between alcohol consumption and risk of hip fracture differs by age and gender in Cohort of Norway: a NOREPOS study. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 29(11), 2457-2467. https://doi.org/10.1007/s00198-018-4627-1
Søgaard AJ, et al. The Association Between Alcohol Consumption and Risk of Hip Fracture Differs By Age and Gender in Cohort of Norway: a NOREPOS Study. Osteoporos Int. 2018;29(11):2457-2467. PubMed PMID: 30006884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between alcohol consumption and risk of hip fracture differs by age and gender in Cohort of Norway: a NOREPOS study. AU - Søgaard,A J, AU - Ranhoff,A H, AU - Meyer,H E, AU - Omsland,T K, AU - Nystad,W, AU - Tell,G S, AU - Holvik,K, Y1 - 2018/07/13/ PY - 2018/02/16/received PY - 2018/06/28/accepted PY - 2018/7/15/pubmed PY - 2019/4/10/medline PY - 2018/7/15/entrez KW - Age KW - Alcohol consumption KW - Amount KW - Frequency KW - Gender KW - Hip fracture SP - 2457 EP - 2467 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 29 IS - 11 N2 - : The association between alcohol consumption and hip fracture differed by gender: Men aged 30-59 years drinking frequently or 14+ gl/week had higher risk than moderate drinkers. No significant association was seen in older men. Women not drinking alcohol had higher risk than those drinking moderately both regarding frequency and amount. INTRODUCTION: We aimed to examine alcohol consumption and risk of hip fracture according to age and gender in the population-based Cohort of Norway (1994-2003). METHODS: Socio-demographics, lifestyle, and health were self-reported and weight and height were measured in 70,568 men and 71,357 women ≥ 30 years. Information on subsequent hip fractures was retrieved from hospitals' electronic patient registries during 1994-2013. Frequency of alcohol consumption was categorized: never/seldom, moderate (≤ 2-3 times/week), or frequent (≥ 4 times/week), and amount as number of glasses per week: 0, 1-6, 7-13, 14-27, and 28+. Type of alcohol (wine vs. beer/hard liquor) was also examined. Cox's proportional hazards regression was used to estimate hazard ratios (HRs) stratified on gender and baseline age < 60 and ≥ 60 years. RESULTS: During median 15-year follow-up, 1558 men and 2511 women suffered a hip fracture. Using moderate drinkers as reference, men < 60 years drinking frequently had multivariable adjusted HR = 1.73 (CI 1.02-2.96) for hip fracture and more than 2.5 times higher risk if they consumed 14+ glasses compared to 1-6 glasses per week. In other groups of age and gender, no statistically significant increased risk was found in those consuming the highest levels of alcohol. Compared to women with moderate or frequent alcohol use, never/seldom-drinking women had the highest fracture risk. In women, use of wine was associated with lower fracture risk than other types of alcohol. CONCLUSIONS: Risk of hip fracture was highest in men < 60 years with the highest frequency and amount of alcohol consumption and in non-drinking women. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/30006884/The_association_between_alcohol_consumption_and_risk_of_hip_fracture_differs_by_age_and_gender_in_Cohort_of_Norway:_a_NOREPOS_study_ L2 - https://doi.org/10.1007/s00198-018-4627-1 DB - PRIME DP - Unbound Medicine ER -