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Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats.
Oxid Med Cell Longev. 2018; 2018:8487248.OM

Abstract

In the present investigation, the effect of olive leaf extract (OLE) on testicular damage induced in rats by an intraperitoneal injection of cisplatin (cis-diamminedichloroplatinum (CDDP)) at a dose of 5 mg/kg was tested. Rats were randomly divided into 4 groups: control, CDDP, OLE, and OLE + CDDP. After 5 days of CDDP treatment, body and testicular weights, histopathological alteration, and serum male sex hormone levels were determined. In addition to the biochemical and immunohistochemical changes in the testes, CDDP caused the disorganization of germinal epithelium and apoptosis by inducing Bax and inhibiting Bcl-2 protein expression. Testicular weights, catalase, serum testosterone, testicular enzymatic (including glutathione peroxidase, glutathione reductase, and superoxide dismutase) along with nonenzymatic (glutathione) antioxidants, and levels of luteinizing and follicle-stimulating hormones were significantly reduced in addition to a significant increase in testicular malondialdehyde and nitrite/nitrate levels when compared with the control group. OLE treatment markedly attenuated both biochemical and histopathological changes. The reproductive beneficial effects of OLE were mediated, at least partly, by inducing the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway.

Authors+Show Affiliations

Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30013722

Citation

Almeer, Rafa S., and Ahmed E. Abdel Moneim. "Evaluation of the Protective Effect of Olive Leaf Extract On Cisplatin-Induced Testicular Damage in Rats." Oxidative Medicine and Cellular Longevity, vol. 2018, 2018, p. 8487248.
Almeer RS, Abdel Moneim AE. Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats. Oxid Med Cell Longev. 2018;2018:8487248.
Almeer, R. S., & Abdel Moneim, A. E. (2018). Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats. Oxidative Medicine and Cellular Longevity, 2018, 8487248. https://doi.org/10.1155/2018/8487248
Almeer RS, Abdel Moneim AE. Evaluation of the Protective Effect of Olive Leaf Extract On Cisplatin-Induced Testicular Damage in Rats. Oxid Med Cell Longev. 2018;2018:8487248. PubMed PMID: 30013722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats. AU - Almeer,Rafa S, AU - Abdel Moneim,Ahmed E, Y1 - 2018/04/26/ PY - 2017/12/08/received PY - 2018/03/13/revised PY - 2018/04/02/accepted PY - 2018/7/18/entrez PY - 2018/7/18/pubmed PY - 2018/10/23/medline SP - 8487248 EP - 8487248 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2018 N2 - In the present investigation, the effect of olive leaf extract (OLE) on testicular damage induced in rats by an intraperitoneal injection of cisplatin (cis-diamminedichloroplatinum (CDDP)) at a dose of 5 mg/kg was tested. Rats were randomly divided into 4 groups: control, CDDP, OLE, and OLE + CDDP. After 5 days of CDDP treatment, body and testicular weights, histopathological alteration, and serum male sex hormone levels were determined. In addition to the biochemical and immunohistochemical changes in the testes, CDDP caused the disorganization of germinal epithelium and apoptosis by inducing Bax and inhibiting Bcl-2 protein expression. Testicular weights, catalase, serum testosterone, testicular enzymatic (including glutathione peroxidase, glutathione reductase, and superoxide dismutase) along with nonenzymatic (glutathione) antioxidants, and levels of luteinizing and follicle-stimulating hormones were significantly reduced in addition to a significant increase in testicular malondialdehyde and nitrite/nitrate levels when compared with the control group. OLE treatment markedly attenuated both biochemical and histopathological changes. The reproductive beneficial effects of OLE were mediated, at least partly, by inducing the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/30013722/Evaluation_of_the_Protective_Effect_of_Olive_Leaf_Extract_on_Cisplatin_Induced_Testicular_Damage_in_Rats_ L2 - https://doi.org/10.1155/2018/8487248 DB - PRIME DP - Unbound Medicine ER -