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Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults.
Clin Nutr ESPEN. 2017 10; 21:1-12.CN

Abstract

Vitamin E is a fat-soluble compound and powerful antioxidant that have been shown to protect the cell membranes against damage caused by free radicals. Human vitamin E supplementation studies are usually limited to α-tocopherol but currently tocotrienols are also available. This study aims to compare the effects of tocotrienol rich fraction (TRF) with α-tocopherol (α-TF) supplementation on oxidative stress in healthy male and female older adults aged 50-55 years old. A total of 71 subjects both male and female aged between 50 and 55 years were divided into groups receiving placebo (n = 23), α-TF (n = 24) and TRF (n = 24) for six months. Blood was taken at baseline (month 0), 3 months and 6 months osf supplementation for determination of plasma malondialdehyde (MDA), protein carbonyl, total DNA damage, vitamin D concentration and vitamin E isomers. α-TF supplementation reduced plasma MDA and protein carbonyl in female subjects after 3 and 6 months. TRF supplementation reduced MDA levels in both males and females as early as 3 months while DNA damage was reduced in females only at 6 months. Supplementation with α-TF and TRF increased plasma vitamin D concentration in both males and females after 6 months, but vitamin D concentration in male subjects were significantly higher compared to female subjects in TRF group. Vitamin E isomer determination showed α-TF, α-tocotrienol and γ-tocotrienol were increased in both male and female subjects. In conclusion, TRF supplementation effects were different from α-TF in reducing oxidative stress markers and vitamin D levels with a more pronounced effect in female subjects.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Goon JA
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Kuala Lumpur, Malaysia. Electronic address: joaan@ukm.edu.my.
Nor Azman NHE
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Kuala Lumpur, Malaysia.
Abdul Ghani SM
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Kuala Lumpur, Malaysia.
Hamid Z
Sime Darby Foods & Beverages Marketing Sdn Bhd, Level 3, Block C, Plantation Tower, Jalan PJU 1A/7, 47301 Petaling Jaya, Selangor, Malaysia.
Wan Ngah WZ
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Kuala Lumpur, Malaysia.

MeSH

ChromansComet AssayDNA DamageDietary SupplementsFemaleHumansMaleMalondialdehydeMiddle AgedOxidative StressPalm OilProtein CarbonylationReactive Oxygen SpeciesTocotrienolsVitamin DVitamin Ealpha-Tocopherol

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30014863

Citation

Goon, Jo Aan, et al. "Comparing Palm Oil Tocotrienol Rich Fraction With Α-tocopherol Supplementation On Oxidative Stress in Healthy Older Adults." Clinical Nutrition ESPEN, vol. 21, 2017, pp. 1-12.
Goon JA, Nor Azman NHE, Abdul Ghani SM, et al. Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults. Clin Nutr ESPEN. 2017;21:1-12.
Goon, J. A., Nor Azman, N. H. E., Abdul Ghani, S. M., Hamid, Z., & Wan Ngah, W. Z. (2017). Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults. Clinical Nutrition ESPEN, 21, 1-12. https://doi.org/10.1016/j.clnesp.2017.07.004
Goon JA, et al. Comparing Palm Oil Tocotrienol Rich Fraction With Α-tocopherol Supplementation On Oxidative Stress in Healthy Older Adults. Clin Nutr ESPEN. 2017;21:1-12. PubMed PMID: 30014863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults. AU - Goon,Jo Aan, AU - Nor Azman,Nor Helwa Ezzah, AU - Abdul Ghani,Siti Madiani, AU - Hamid,Zalina, AU - Wan Ngah,Wan Zurinah, Y1 - 2017/07/29/ PY - 2017/07/12/received PY - 2017/07/16/accepted PY - 2018/7/18/entrez PY - 2018/7/18/pubmed PY - 2019/6/4/medline KW - Aging KW - Antioxidant KW - Oxidative stress KW - Tocopherol KW - Tocotrienol SP - 1 EP - 12 JF - Clinical nutrition ESPEN JO - Clin Nutr ESPEN VL - 21 N2 - Vitamin E is a fat-soluble compound and powerful antioxidant that have been shown to protect the cell membranes against damage caused by free radicals. Human vitamin E supplementation studies are usually limited to α-tocopherol but currently tocotrienols are also available. This study aims to compare the effects of tocotrienol rich fraction (TRF) with α-tocopherol (α-TF) supplementation on oxidative stress in healthy male and female older adults aged 50-55 years old. A total of 71 subjects both male and female aged between 50 and 55 years were divided into groups receiving placebo (n = 23), α-TF (n = 24) and TRF (n = 24) for six months. Blood was taken at baseline (month 0), 3 months and 6 months osf supplementation for determination of plasma malondialdehyde (MDA), protein carbonyl, total DNA damage, vitamin D concentration and vitamin E isomers. α-TF supplementation reduced plasma MDA and protein carbonyl in female subjects after 3 and 6 months. TRF supplementation reduced MDA levels in both males and females as early as 3 months while DNA damage was reduced in females only at 6 months. Supplementation with α-TF and TRF increased plasma vitamin D concentration in both males and females after 6 months, but vitamin D concentration in male subjects were significantly higher compared to female subjects in TRF group. Vitamin E isomer determination showed α-TF, α-tocotrienol and γ-tocotrienol were increased in both male and female subjects. In conclusion, TRF supplementation effects were different from α-TF in reducing oxidative stress markers and vitamin D levels with a more pronounced effect in female subjects. SN - 2405-4577 UR - https://www.unboundmedicine.com/medline/citation/30014863/Comparing_palm_oil_tocotrienol_rich_fraction_with_α_tocopherol_supplementation_on_oxidative_stress_in_healthy_older_adults_ DB - PRIME DP - Unbound Medicine ER -