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Zika virus outbreak in the Pacific: Vector competence of regional vectors.
PLoS Negl Trop Dis 2018; 12(7):e0006637PN

Abstract

BACKGROUND

In 2013, Zika virus (ZIKV) emerged in French Polynesia and spread through the Pacific region between 2013 and 2017. Several potential Aedes mosquitoes may have contributed to the ZIKV transmission including Aedes aegypti, the main arbovirus vector in the region, and Aedes polynesiensis, vector of lymphatic filariasis and secondary vector of dengue virus. The aim of this study was to analyze the ability of these two Pacific vectors to transmit ZIKV at a regional scale, through the evaluation and comparison of the vector competence of wild Ae. aegypti and Ae. polynesiensis populations from different Pacific islands for a ZIKV strain which circulated in this region during the 2013-2017 outbreak.

METHODOLOGY/PRINCIPAL FINDINGS

Field Ae. aegypti (three populations) and Ae. polynesiensis (two populations) from the Pacific region were collected for this study. Female mosquitoes were orally exposed to ZIKV (107 TCID50/mL) isolated in the region in 2014. At 6, 9, 14 and 21 days post-infection, mosquito bodies (thorax and abdomen), heads and saliva were analyzed to measure infection, dissemination, transmission rates and transmission efficiency, respectively. According to our results, ZIKV infection rates were heterogeneous between the Ae. aegypti populations, but the dissemination rates were moderate and more homogenous between these populations. For Ae. polynesiensis, infection rates were less heterogeneous between the two populations tested. The transmission rate and efficiency results revealed a low vector competence for ZIKV of the different Aedes vector populations under study.

CONCLUSION/SIGNIFICANCE

Our results indicated a low ZIKV transmission by Ae. aegypti and Ae. polynesiensis tested from the Pacific region. These results were unexpected and suggest the importance of other factors especially the vector density, the mosquito lifespan or the large immunologically naive fraction of the population that may have contributed to the rapid spread of the ZIKV in the Pacific region during the 2013-2017 outbreak.

Authors+Show Affiliations

Institut Pasteur de Nouvelle-Calédonie, URE-Dengue et autres Arboviroses, Nouméa, New Caledonia.Institut Pasteur, Arboviruses and Insect Vectors Laboratory, Paris, France.Institut Pasteur, Arboviruses and Insect Vectors Laboratory, Paris, France.Institut Pasteur de Nouvelle-Calédonie, URE-Dengue et autres Arboviroses, Nouméa, New Caledonia.Unit of Emerging Infectious Diseases, Institut Louis Malarde, French Polynesia & Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditérranée Infection, Marseille, France.Institut de Recherche pour le Développement, UMR MIVEGEC IRD, CNRS, UM, Montpellier, France.Institut Pasteur de Nouvelle-Calédonie, URE-Entomologie Médicale, Nouméa, New Caledonia.Institut Pasteur, Arboviruses and Insect Vectors Laboratory, Paris, France.Institut Pasteur de Nouvelle-Calédonie, URE-Dengue et autres Arboviroses, Nouméa, New Caledonia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30016372

Citation

Calvez, Elodie, et al. "Zika Virus Outbreak in the Pacific: Vector Competence of Regional Vectors." PLoS Neglected Tropical Diseases, vol. 12, no. 7, 2018, pp. e0006637.
Calvez E, Mousson L, Vazeille M, et al. Zika virus outbreak in the Pacific: Vector competence of regional vectors. PLoS Negl Trop Dis. 2018;12(7):e0006637.
Calvez, E., Mousson, L., Vazeille, M., O'Connor, O., Cao-Lormeau, V. M., Mathieu-Daudé, F., ... Dupont-Rouzeyrol, M. (2018). Zika virus outbreak in the Pacific: Vector competence of regional vectors. PLoS Neglected Tropical Diseases, 12(7), pp. e0006637. doi:10.1371/journal.pntd.0006637.
Calvez E, et al. Zika Virus Outbreak in the Pacific: Vector Competence of Regional Vectors. PLoS Negl Trop Dis. 2018;12(7):e0006637. PubMed PMID: 30016372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zika virus outbreak in the Pacific: Vector competence of regional vectors. AU - Calvez,Elodie, AU - Mousson,Laurence, AU - Vazeille,Marie, AU - O'Connor,Olivia, AU - Cao-Lormeau,Van-Mai, AU - Mathieu-Daudé,Françoise, AU - Pocquet,Nicolas, AU - Failloux,Anna-Bella, AU - Dupont-Rouzeyrol,Myrielle, Y1 - 2018/07/17/ PY - 2018/02/22/received PY - 2018/06/25/accepted PY - 2018/07/27/revised PY - 2018/7/18/pubmed PY - 2018/12/12/medline PY - 2018/7/18/entrez SP - e0006637 EP - e0006637 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 12 IS - 7 N2 - BACKGROUND: In 2013, Zika virus (ZIKV) emerged in French Polynesia and spread through the Pacific region between 2013 and 2017. Several potential Aedes mosquitoes may have contributed to the ZIKV transmission including Aedes aegypti, the main arbovirus vector in the region, and Aedes polynesiensis, vector of lymphatic filariasis and secondary vector of dengue virus. The aim of this study was to analyze the ability of these two Pacific vectors to transmit ZIKV at a regional scale, through the evaluation and comparison of the vector competence of wild Ae. aegypti and Ae. polynesiensis populations from different Pacific islands for a ZIKV strain which circulated in this region during the 2013-2017 outbreak. METHODOLOGY/PRINCIPAL FINDINGS: Field Ae. aegypti (three populations) and Ae. polynesiensis (two populations) from the Pacific region were collected for this study. Female mosquitoes were orally exposed to ZIKV (107 TCID50/mL) isolated in the region in 2014. At 6, 9, 14 and 21 days post-infection, mosquito bodies (thorax and abdomen), heads and saliva were analyzed to measure infection, dissemination, transmission rates and transmission efficiency, respectively. According to our results, ZIKV infection rates were heterogeneous between the Ae. aegypti populations, but the dissemination rates were moderate and more homogenous between these populations. For Ae. polynesiensis, infection rates were less heterogeneous between the two populations tested. The transmission rate and efficiency results revealed a low vector competence for ZIKV of the different Aedes vector populations under study. CONCLUSION/SIGNIFICANCE: Our results indicated a low ZIKV transmission by Ae. aegypti and Ae. polynesiensis tested from the Pacific region. These results were unexpected and suggest the importance of other factors especially the vector density, the mosquito lifespan or the large immunologically naive fraction of the population that may have contributed to the rapid spread of the ZIKV in the Pacific region during the 2013-2017 outbreak. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/30016372/Zika_virus_outbreak_in_the_Pacific:_Vector_competence_of_regional_vectors_ L2 - http://dx.plos.org/10.1371/journal.pntd.0006637 DB - PRIME DP - Unbound Medicine ER -