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In vitro antimicrobial activity of monensin against common clinical isolates associated with canine otitis externa.
Comp Immunol Microbiol Infect Dis. 2018 Apr; 57:34-38.CI

Abstract

Antimicrobial resistance and antimicrobial stewardship are of ever-increasing importance in veterinary medicine. Multidrug-resistant infections of the canine skin and ear continue to emerge, but the use of antibiotic classes of critical importance to human medicine may not represent good antimicrobial stewardship. Repurposing of old drugs that are not used in human medicine is one approach that addresses both these issues. In this study, the minimal inhibitory concentration (MIC) of monensin for 111 bacterial and yeast canine otitis isolates was determined using microdilution methodology according to Clinical Laboratory Standards Institute (CLSI) guidelines. Monensin was effective against all Gram-positive bacteria including the multidrug-resistant staphylococcal strains with MICs ranging from 1 to 4 μg/ml, but lacked antimicrobial activity against Gram-negative bacteria and yeast isolates. Monensin has potential to be incorporated as one of the main components in an otic formulation.

Authors+Show Affiliations

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Mudla Wirra Rd, Roseworthy, SA 5371, Australia. Electronic address: weiyee.chan@adelaide.edu.au.Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Mudla Wirra Rd, Roseworthy, SA 5371, Australia.Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Mudla Wirra Rd, Roseworthy, SA 5371, Australia.Luoda Pharma Pty. Ltd., 1/304-318, The Kingsway, Caringbah, NSW 2229, Australia.Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Mudla Wirra Rd, Roseworthy, SA 5371, Australia.Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Mudla Wirra Rd, Roseworthy, SA 5371, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30017076

Citation

Chan, Wei Yee, et al. "In Vitro Antimicrobial Activity of Monensin Against Common Clinical Isolates Associated With Canine Otitis Externa." Comparative Immunology, Microbiology and Infectious Diseases, vol. 57, 2018, pp. 34-38.
Chan WY, Hickey EE, Khazandi M, et al. In vitro antimicrobial activity of monensin against common clinical isolates associated with canine otitis externa. Comp Immunol Microbiol Infect Dis. 2018;57:34-38.
Chan, W. Y., Hickey, E. E., Khazandi, M., Page, S. W., Trott, D. J., & Hill, P. B. (2018). In vitro antimicrobial activity of monensin against common clinical isolates associated with canine otitis externa. Comparative Immunology, Microbiology and Infectious Diseases, 57, 34-38. https://doi.org/10.1016/j.cimid.2018.05.001
Chan WY, et al. In Vitro Antimicrobial Activity of Monensin Against Common Clinical Isolates Associated With Canine Otitis Externa. Comp Immunol Microbiol Infect Dis. 2018;57:34-38. PubMed PMID: 30017076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antimicrobial activity of monensin against common clinical isolates associated with canine otitis externa. AU - Chan,Wei Yee, AU - Hickey,Elizabeth E, AU - Khazandi,Manouchehr, AU - Page,Stephen W, AU - Trott,Darren J, AU - Hill,Peter B, Y1 - 2018/05/12/ PY - 2017/12/12/received PY - 2018/03/26/revised PY - 2018/05/05/accepted PY - 2018/7/19/entrez PY - 2018/7/19/pubmed PY - 2018/10/31/medline KW - Antimicrobial susceptibility KW - Canine KW - MIC KW - Monensin KW - Otitis externa SP - 34 EP - 38 JF - Comparative immunology, microbiology and infectious diseases JO - Comp. Immunol. Microbiol. Infect. Dis. VL - 57 N2 - Antimicrobial resistance and antimicrobial stewardship are of ever-increasing importance in veterinary medicine. Multidrug-resistant infections of the canine skin and ear continue to emerge, but the use of antibiotic classes of critical importance to human medicine may not represent good antimicrobial stewardship. Repurposing of old drugs that are not used in human medicine is one approach that addresses both these issues. In this study, the minimal inhibitory concentration (MIC) of monensin for 111 bacterial and yeast canine otitis isolates was determined using microdilution methodology according to Clinical Laboratory Standards Institute (CLSI) guidelines. Monensin was effective against all Gram-positive bacteria including the multidrug-resistant staphylococcal strains with MICs ranging from 1 to 4 μg/ml, but lacked antimicrobial activity against Gram-negative bacteria and yeast isolates. Monensin has potential to be incorporated as one of the main components in an otic formulation. SN - 1878-1667 UR - https://www.unboundmedicine.com/medline/citation/30017076/In_vitro_antimicrobial_activity_of_monensin_against_common_clinical_isolates_associated_with_canine_otitis_externa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-9571(18)30028-6 DB - PRIME DP - Unbound Medicine ER -