Tags

Type your tag names separated by a space and hit enter

Characteristics of multi-component formulation granules formed using distributive mixing elements in twin screw granulation.
Drug Dev Ind Pharm. 2018 Nov; 44(11):1826-1837.DD

Abstract

This work examines the influence of pharmaceutical powder formulation characteristics on granule properties formed using distributive mixing elements (DMEs) in twin screw granulation. High and low drug dose formulations with three different active pharmaceutical ingredients (APIs) were considered. The type and concentration of the API in the formulation significantly affected the dry blend particle size distribution and the wet blend dynamic yield strength. However, despite the differences in blend properties, the granule size distributions were not significantly affected by the type of API used. The granule size distributions were solely the functions of the liquid-to-solid ratio and screw element geometry. However, the granule porosities were observed to be dependent on both the liquid-to-solid ratio and the dynamic yield strength of the blends. This work is the first to study the influence of drug loading and API type on the granule attributes produced using distributive mixing elements.

Authors+Show Affiliations

a Davidson School of Chemical Engineering , Purdue University , West Lafayette (IN), USA.a Davidson School of Chemical Engineering , Purdue University , West Lafayette (IN), USA.a Davidson School of Chemical Engineering , Purdue University , West Lafayette (IN), USA.b Pharmaceutical Technology and Development , AstraZeneca, Silk Road Business Park Charter Way , Cheshire , UK.b Pharmaceutical Technology and Development , AstraZeneca, Silk Road Business Park Charter Way , Cheshire , UK.c Department of Chemical and Biological Engineering , University of Sheffield , Sheffield , UK.d School of Mechanical Engineering , Purdue University , West Lafayette (IN) , USA. e Department of Industrial and Physical Pharmacy , Purdue University , West Lafayette (IN) USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30027770

Citation

Pradhan, Shankali U., et al. "Characteristics of Multi-component Formulation Granules Formed Using Distributive Mixing Elements in Twin Screw Granulation." Drug Development and Industrial Pharmacy, vol. 44, no. 11, 2018, pp. 1826-1837.
Pradhan SU, Sen M, Li J, et al. Characteristics of multi-component formulation granules formed using distributive mixing elements in twin screw granulation. Drug Dev Ind Pharm. 2018;44(11):1826-1837.
Pradhan, S. U., Sen, M., Li, J., Gabbott, I., Reynolds, G., Litster, J. D., & Wassgren, C. R. (2018). Characteristics of multi-component formulation granules formed using distributive mixing elements in twin screw granulation. Drug Development and Industrial Pharmacy, 44(11), 1826-1837. https://doi.org/10.1080/03639045.2018.1503293
Pradhan SU, et al. Characteristics of Multi-component Formulation Granules Formed Using Distributive Mixing Elements in Twin Screw Granulation. Drug Dev Ind Pharm. 2018;44(11):1826-1837. PubMed PMID: 30027770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of multi-component formulation granules formed using distributive mixing elements in twin screw granulation. AU - Pradhan,Shankali U, AU - Sen,Maitraye, AU - Li,Jiayu, AU - Gabbott,Ian, AU - Reynolds,Gavin, AU - Litster,James D, AU - Wassgren,Carl R, Y1 - 2018/08/31/ PY - 2018/7/22/pubmed PY - 2019/1/24/medline PY - 2018/7/21/entrez KW - Distributive mixing elements KW - formulation properties KW - granule breakage KW - granule properties KW - twin screw granulation SP - 1826 EP - 1837 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 44 IS - 11 N2 - This work examines the influence of pharmaceutical powder formulation characteristics on granule properties formed using distributive mixing elements (DMEs) in twin screw granulation. High and low drug dose formulations with three different active pharmaceutical ingredients (APIs) were considered. The type and concentration of the API in the formulation significantly affected the dry blend particle size distribution and the wet blend dynamic yield strength. However, despite the differences in blend properties, the granule size distributions were not significantly affected by the type of API used. The granule size distributions were solely the functions of the liquid-to-solid ratio and screw element geometry. However, the granule porosities were observed to be dependent on both the liquid-to-solid ratio and the dynamic yield strength of the blends. This work is the first to study the influence of drug loading and API type on the granule attributes produced using distributive mixing elements. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/30027770/Characteristics_of_multi_component_formulation_granules_formed_using_distributive_mixing_elements_in_twin_screw_granulation_ L2 - https://www.tandfonline.com/doi/full/10.1080/03639045.2018.1503293 DB - PRIME DP - Unbound Medicine ER -