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Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project.
J Gerontol A Biol Sci Med Sci. 2019 05 16; 74(6):827-834.JG

Abstract

BACKGROUND

It is unclear whether older men with osteopenia/osteoporosis and sarcopenia (so-called osteosarcopenia) are at greater risk of falls and fractures than those with either condition alone.

METHODS

One thousand five hundred seventy-five community-dwelling men aged ≥70 years had appendicular lean mass, total hip and lumbar spine bone mineral density determined by dual-energy x-ray absorptiometry, and completed hand grip strength and gait speed tests. Osteopenia/osteoporosis was defined as a T-score at any site ≤-1.0 SD. Sarcopenia was defined using the European Working Group on Sarcopenia algorithm. Participants were contacted every 4 months for 6 ± 2 years to ascertain incident fractures (confirmed by radiographic reports) and for 2 years for incident falls.

RESULTS

Prevalence of osteosarcopenia was 8%, while 34% of participants had osteopenia/osteoporosis alone and 7% had sarcopenia alone. Men with osteosarcopenia had significantly increased fall (incidence rate ratio: 1.41; 95% confidence interval [CI]: 1.02 to 1.95) and fracture risk (hazard ratio: 1.87; 95% CI: 1.07 to 3.26) compared with men with neither osteopenia/osteoporosis nor sarcopenia. There was no statistical interaction between osteopenia/osteoporosis and sarcopenia, and falls and fracture risk were not different for osteosarcopenia compared with either condition alone (all p > .05).

CONCLUSIONS

Community-dwelling older men with combined osteopenia/osteoporosis and sarcopenia do not have increased falls and fracture risk compared with those with either condition. Further research is required to clarify whether the term "osteosarcopenia" has any meaning above and beyond either term alone and therefore potential clinical utility for falls and fracture prediction.

Authors+Show Affiliations

School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia. Australian Institute for Musculoskeletal Science, Department of Medicine-Western Health, The University of Melbourne, St Albans, Victoria, Australia.Bone Research Program, ANZAC Research Institute, University of Sydney, New South Wales, Australia. Department of Endocrinology and Metabolism, Concord Hospital, University of Sydney, New South Wales, Australia.School of Public Health, University of Sydney, New South Wales, Australia. Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, New South Wales, Australia. The ARC Centre of Excellence in Population Ageing Research, University of Sydney, New South Wales, Australia.Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, New South Wales, Australia.Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, New South Wales, Australia.ANZAC Research Institute, University of Sydney, New South Wales, Australia. Charles Perkins Centre, University of Sydney, New South Wales, Australia.ANZAC Research Institute, University of Sydney, New South Wales, Australia. Department of Andrology, Concord Hospital, University of Sydney, New South Wales, Australia.Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, New South Wales, Australia.Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, New South Wales, Australia. School of Life and Environmental Sciences, Charles Perkins Centre, University of Sydney, New South Wales, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30032209

Citation

Scott, David, et al. "Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? the Concord Health and Ageing in Men Project." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 74, no. 6, 2019, pp. 827-834.
Scott D, Seibel M, Cumming R, et al. Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2019;74(6):827-834.
Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D. G., Handelsman, D. J., Waite, L. M., & Hirani, V. (2019). Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 74(6), 827-834. https://doi.org/10.1093/gerona/gly162
Scott D, et al. Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? the Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2019 05 16;74(6):827-834. PubMed PMID: 30032209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. AU - Scott,David, AU - Seibel,Markus, AU - Cumming,Robert, AU - Naganathan,Vasi, AU - Blyth,Fiona, AU - Le Couteur,David G, AU - Handelsman,David J, AU - Waite,Louise M, AU - Hirani,Vasant, PY - 2017/11/23/received PY - 2018/7/23/pubmed PY - 2020/2/25/medline PY - 2018/7/23/entrez KW - Bone aging KW - Falls KW - Hip fracture KW - Muscle KW - Osteosarcopenia SP - 827 EP - 834 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. VL - 74 IS - 6 N2 - BACKGROUND: It is unclear whether older men with osteopenia/osteoporosis and sarcopenia (so-called osteosarcopenia) are at greater risk of falls and fractures than those with either condition alone. METHODS: One thousand five hundred seventy-five community-dwelling men aged ≥70 years had appendicular lean mass, total hip and lumbar spine bone mineral density determined by dual-energy x-ray absorptiometry, and completed hand grip strength and gait speed tests. Osteopenia/osteoporosis was defined as a T-score at any site ≤-1.0 SD. Sarcopenia was defined using the European Working Group on Sarcopenia algorithm. Participants were contacted every 4 months for 6 ± 2 years to ascertain incident fractures (confirmed by radiographic reports) and for 2 years for incident falls. RESULTS: Prevalence of osteosarcopenia was 8%, while 34% of participants had osteopenia/osteoporosis alone and 7% had sarcopenia alone. Men with osteosarcopenia had significantly increased fall (incidence rate ratio: 1.41; 95% confidence interval [CI]: 1.02 to 1.95) and fracture risk (hazard ratio: 1.87; 95% CI: 1.07 to 3.26) compared with men with neither osteopenia/osteoporosis nor sarcopenia. There was no statistical interaction between osteopenia/osteoporosis and sarcopenia, and falls and fracture risk were not different for osteosarcopenia compared with either condition alone (all p > .05). CONCLUSIONS: Community-dwelling older men with combined osteopenia/osteoporosis and sarcopenia do not have increased falls and fracture risk compared with those with either condition. Further research is required to clarify whether the term "osteosarcopenia" has any meaning above and beyond either term alone and therefore potential clinical utility for falls and fracture prediction. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/30032209/Does_Combined_Osteopenia/Osteoporosis_and_Sarcopenia_Confer_Greater_Risk_of_Falls_and_Fracture_Than_Either_Condition_Alone_in_Older_Men_The_Concord_Health_and_Ageing_in_Men_Project_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/gly162 DB - PRIME DP - Unbound Medicine ER -