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Vitamin B12 Deficiency in Children With Infantile Spasms: A Case-Control Study.
J Child Neurol. 2018 10; 33(12):767-771.JC

Abstract

There have been few case reports showing association of vitamin B12 deficiency with infantile spasms. We planned this study to see if there was an association of serum vitamin B12 deficiency in children with development of infantile spasms. Cases included children with infantile spasms of ages 6 months to 3 years. The controls were children in the same age group who had global developmental delay but no history of epileptic spasms. Mean serum vitamin B12, serum homocysteine, and urinary methylmalonic acid levels were measured in both groups and compared. Children with infantile spasms had lower mean serum vitamin B12 levels (354.1 pg/mL; standard deviation 234.1 pg/mL) as compared to children with global developmental delay without spasms (466.7 pg/mL; standard deviation 285.5 pg/mL) (P value < .05). Mean serum homocysteine level (13.9 vs 7.8 μmol/L, P = .02) and mean urinary methylmalonic acid level (68.1 mmol/mol of creatinine vs 26.1 mmol/mol of creatinine, P = .03) were elevated in children with infantile spasms than in controls. Fourteen children (35.0%) with infantile spasms were vitamin B12 deficient compared with 3 (7.50%) controls (P = .005). Thus, vitamin B12 deficiency may have an association with infantile spasms. More studies are needed before recommending routine measurement of serum B12 levels in children with infantile spasms.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Meena MK
1 Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India.
Sharma S
2 Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India.
Bhasin H
1 Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India.
Jain P
2 Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India.
Kapoor S
3 Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.
Jain A
4 Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India.
Aneja S
2 Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India.

MeSH

Asphyxia NeonatorumCase-Control StudiesChild, PreschoolDevelopmental DisabilitiesFemaleHomocysteineHumansInfantMaleMethylmalonic AcidRetrospective StudiesSpasms, InfantileVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30032694

Citation

Meena, Mahender K., et al. "Vitamin B12 Deficiency in Children With Infantile Spasms: a Case-Control Study." Journal of Child Neurology, vol. 33, no. 12, 2018, pp. 767-771.
Meena MK, Sharma S, Bhasin H, et al. Vitamin B12 Deficiency in Children With Infantile Spasms: A Case-Control Study. J Child Neurol. 2018;33(12):767-771.
Meena, M. K., Sharma, S., Bhasin, H., Jain, P., Kapoor, S., Jain, A., & Aneja, S. (2018). Vitamin B12 Deficiency in Children With Infantile Spasms: A Case-Control Study. Journal of Child Neurology, 33(12), 767-771. https://doi.org/10.1177/0883073818787062
Meena MK, et al. Vitamin B12 Deficiency in Children With Infantile Spasms: a Case-Control Study. J Child Neurol. 2018;33(12):767-771. PubMed PMID: 30032694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12 Deficiency in Children With Infantile Spasms: A Case-Control Study. AU - Meena,Mahender K, AU - Sharma,Suvasini, AU - Bhasin,Himani, AU - Jain,Puneet, AU - Kapoor,Seema, AU - Jain,Anju, AU - Aneja,Satinder, Y1 - 2018/07/22/ PY - 2018/7/24/pubmed PY - 2019/10/8/medline PY - 2018/7/24/entrez KW - global developmental delay KW - homocysteine KW - infantile spasms KW - methylmalonic acid KW - vitamin B12 SP - 767 EP - 771 JF - Journal of child neurology JO - J Child Neurol VL - 33 IS - 12 N2 - There have been few case reports showing association of vitamin B12 deficiency with infantile spasms. We planned this study to see if there was an association of serum vitamin B12 deficiency in children with development of infantile spasms. Cases included children with infantile spasms of ages 6 months to 3 years. The controls were children in the same age group who had global developmental delay but no history of epileptic spasms. Mean serum vitamin B12, serum homocysteine, and urinary methylmalonic acid levels were measured in both groups and compared. Children with infantile spasms had lower mean serum vitamin B12 levels (354.1 pg/mL; standard deviation 234.1 pg/mL) as compared to children with global developmental delay without spasms (466.7 pg/mL; standard deviation 285.5 pg/mL) (P value < .05). Mean serum homocysteine level (13.9 vs 7.8 μmol/L, P = .02) and mean urinary methylmalonic acid level (68.1 mmol/mol of creatinine vs 26.1 mmol/mol of creatinine, P = .03) were elevated in children with infantile spasms than in controls. Fourteen children (35.0%) with infantile spasms were vitamin B12 deficient compared with 3 (7.50%) controls (P = .005). Thus, vitamin B12 deficiency may have an association with infantile spasms. More studies are needed before recommending routine measurement of serum B12 levels in children with infantile spasms. SN - 1708-8283 UR - https://www.unboundmedicine.com/medline/citation/30032694/Vitamin_B12_Deficiency_in_Children_With_Infantile_Spasms:_A_Case_Control_Study_ DB - PRIME DP - Unbound Medicine ER -