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Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial.
Electron Physician. 2018 Jun; 10(6):6912-6919.EP

Abstract

Background

Recurrent aphthous stomatitis (RAS) is one of the most common painful oral lesions of which there is no certain treatment.

Objective

The aim of this study was to determine the effect of Chitosan mouthwash 0.5% on RAS.

Methods

This randomized double-blind crossover clinical trial was conducted at a dental school in Babol, Iran, from 2015 to 2016. Twenty patients with a history of minor aphthous stomatitis were entered into this study. All patients were initially monitored in the first episode without treatment, and then were randomly treated in three other episodes with Chitosan, Triamcinolone or Biogel mouthwashes. The ulcer size and pain intensity by using visual analogous score (VAS) were recorded in each episode. Data were analyzed by ANOVA and Tukey test. We used SPSS version 20 to analyze data.

Results

The mean ulcer size on the fifth day (p=0.026, p=0.042, respectively) and VAS on the third and fifth days (p=0.011, p=0.013, respectively) were significantly less in Triamcinolone and Chitosan groups than Biogel and the no treatment episode. There were no significant differences between Chitosan and Triamcinolone groups in the average ulcer size and pain intensity in all the examination days.

Conclusions

Chitosan mouthwash is effective on pain relief and reducing ulcer size of minor aphthous stomatitis and this effect is almost the same as Triamcinolone mouthwash.

Clinical trial registration

The study was registered and approved by Iranian Registry of Clinical Trials (http://www.irct.ir) with IRCT ID: IRCT2015030718753N2.

Funding

The study was funded by Deputy of Research and Technology of Babol University of Medical Sciences (ref. no.: 9133625).

Authors+Show Affiliations

DDS of Oral and Maxillofacial Medicine, Avicenna Medical Center, Mazandaran University of Medical Sciences, Sari, Iran.Ph.D. of Pharmacology& Toxicology, Professor, Faculty of Medicine, Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.Ph.D. of Pharmaceutics Sciences, Faculty of Medicine, Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.DDS of Oral and Maxillofacial Medicine, Assistant Professor, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.DDS of Oral and Maxillofacial Medicine, Professor, Faculty of Dentistry, Oral Health Research Center, Babol University of Medical Sciences, Babol, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30034658

Citation

Rahmani, Fatemeh, et al. "Effect of 0.5% Chitosan Mouthwash On Recurrent Aphthous Stomatitis: a Randomized Double-blind Crossover Clinical Trial." Electronic Physician, vol. 10, no. 6, 2018, pp. 6912-6919.
Rahmani F, Moghadamnia AA, Kazemi S, et al. Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial. Electron Physician. 2018;10(6):6912-6919.
Rahmani, F., Moghadamnia, A. A., Kazemi, S., Shirzad, A., & Motallebnejad, M. (2018). Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial. Electronic Physician, 10(6), 6912-6919. https://doi.org/10.19082/6912
Rahmani F, et al. Effect of 0.5% Chitosan Mouthwash On Recurrent Aphthous Stomatitis: a Randomized Double-blind Crossover Clinical Trial. Electron Physician. 2018;10(6):6912-6919. PubMed PMID: 30034658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial. AU - Rahmani,Fatemeh, AU - Moghadamnia,Ali Akbar, AU - Kazemi,Sohrab, AU - Shirzad,Atena, AU - Motallebnejad,Mina, Y1 - 2018/06/25/ PY - 2017/01/15/received PY - 2018/05/08/accepted PY - 2018/7/24/entrez PY - 2018/7/24/pubmed PY - 2018/7/24/medline KW - Chitosan KW - Mouthwash KW - Recurrent aphthous stomatitis KW - Triamcinolone SP - 6912 EP - 6919 JF - Electronic physician JO - Electron Physician VL - 10 IS - 6 N2 - Background: Recurrent aphthous stomatitis (RAS) is one of the most common painful oral lesions of which there is no certain treatment. Objective: The aim of this study was to determine the effect of Chitosan mouthwash 0.5% on RAS. Methods: This randomized double-blind crossover clinical trial was conducted at a dental school in Babol, Iran, from 2015 to 2016. Twenty patients with a history of minor aphthous stomatitis were entered into this study. All patients were initially monitored in the first episode without treatment, and then were randomly treated in three other episodes with Chitosan, Triamcinolone or Biogel mouthwashes. The ulcer size and pain intensity by using visual analogous score (VAS) were recorded in each episode. Data were analyzed by ANOVA and Tukey test. We used SPSS version 20 to analyze data. Results: The mean ulcer size on the fifth day (p=0.026, p=0.042, respectively) and VAS on the third and fifth days (p=0.011, p=0.013, respectively) were significantly less in Triamcinolone and Chitosan groups than Biogel and the no treatment episode. There were no significant differences between Chitosan and Triamcinolone groups in the average ulcer size and pain intensity in all the examination days. Conclusions: Chitosan mouthwash is effective on pain relief and reducing ulcer size of minor aphthous stomatitis and this effect is almost the same as Triamcinolone mouthwash. Clinical trial registration: The study was registered and approved by Iranian Registry of Clinical Trials (http://www.irct.ir) with IRCT ID: IRCT2015030718753N2. Funding: The study was funded by Deputy of Research and Technology of Babol University of Medical Sciences (ref. no.: 9133625). SN - 2008-5842 UR - https://www.unboundmedicine.com/medline/citation/30034658/Effect_of_0_5_Chitosan_mouthwash_on_recurrent_aphthous_stomatitis:_a_randomized_double_blind_crossover_clinical_trial_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30034658/ DB - PRIME DP - Unbound Medicine ER -
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