Tags

Type your tag names separated by a space and hit enter

Altered white matter microarchitecture in amyotrophic lateral sclerosis: A voxel-based meta-analysis of diffusion tensor imaging.
Neuroimage Clin. 2018; 19:122-129.NC

Abstract

Background

The results of recent diffusion tensor imaging (DTI) studies on amyotrophic lateral sclerosis (ALS) are inconclusive and controversial. We performed a voxel-based meta-analysis to identify a statistical consensus among published DTI studies of altered white matter (WM) microarchitecture in ALS.

Methods

A systematic search was conducted for relevant studies that used voxel-wise analyses of WM microarchitecture in patients with ALS. Anisotropic effect size-signed differential mapping (AES-SDM) was applied to analyze fractional anisotropy (FA) differences between ALS patients and healthy controls. Meta-regression analysis was used to explore the effects of clinical characteristics on WM integrity in patients with ALS.

Results

A total of 14 studies with 16 datasets that included 396 patients and 360 healthy controls were identified. The pooled meta-analysis revealed that patients with ALS exhibited significant FA reductions in two clusters relative to healthy controls. The largest cluster exhibited a peak coordinate in the left corona radiata, extending to the body and splenium of the corpus callosum, left superior longitudinal fasciculus, posterior limb of the internal capsule, right corona radiata, and bilateral cingulate gyrus. The other cluster exhibited decreased FA in the right corticospinal tract that extended to the right cerebral peduncle. The Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) score was positively correlated with the FA reduction in the left corona radiata. Mean age and illness duration were not linearly correlated with the FA reductions.

Conclusions

This study provides a thorough profile of WM microarchitecture alterations in patients with ALS and further evidence that the neuronal degeneration is not limited to the corticospinal tract but also includes extra-motor areas, which supports the view that ALS is a multisystem degenerative disorder that involves the white matter.

Authors+Show Affiliations

Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China; Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.Department of Psychoradiology, Chengdu Mental Health Center, Chengdu 610031, China.Department of Psychoradiology, Chengdu Mental Health Center, Chengdu 610031, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: qiyonggong@hmrrc.org.cn.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: zhiyunjia@hotmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30035009

Citation

Zhang, Feifei, et al. "Altered White Matter Microarchitecture in Amyotrophic Lateral Sclerosis: a Voxel-based Meta-analysis of Diffusion Tensor Imaging." NeuroImage. Clinical, vol. 19, 2018, pp. 122-129.
Zhang F, Chen G, He M, et al. Altered white matter microarchitecture in amyotrophic lateral sclerosis: A voxel-based meta-analysis of diffusion tensor imaging. Neuroimage Clin. 2018;19:122-129.
Zhang, F., Chen, G., He, M., Dai, J., Shang, H., Gong, Q., & Jia, Z. (2018). Altered white matter microarchitecture in amyotrophic lateral sclerosis: A voxel-based meta-analysis of diffusion tensor imaging. NeuroImage. Clinical, 19, 122-129. https://doi.org/10.1016/j.nicl.2018.04.005
Zhang F, et al. Altered White Matter Microarchitecture in Amyotrophic Lateral Sclerosis: a Voxel-based Meta-analysis of Diffusion Tensor Imaging. Neuroimage Clin. 2018;19:122-129. PubMed PMID: 30035009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered white matter microarchitecture in amyotrophic lateral sclerosis: A voxel-based meta-analysis of diffusion tensor imaging. AU - Zhang,Feifei, AU - Chen,Guangxiang, AU - He,Manxi, AU - Dai,Jing, AU - Shang,Huifang, AU - Gong,Qiyong, AU - Jia,Zhiyun, Y1 - 2018/04/04/ PY - 2017/12/19/received PY - 2018/02/18/revised PY - 2018/04/01/accepted PY - 2018/7/24/entrez PY - 2018/7/24/pubmed PY - 2019/1/31/medline KW - Amyotrophic lateral sclerosis KW - Diffusion tensor imaging KW - MRI KW - Psychoradiology SP - 122 EP - 129 JF - NeuroImage. Clinical JO - Neuroimage Clin VL - 19 N2 - Background: The results of recent diffusion tensor imaging (DTI) studies on amyotrophic lateral sclerosis (ALS) are inconclusive and controversial. We performed a voxel-based meta-analysis to identify a statistical consensus among published DTI studies of altered white matter (WM) microarchitecture in ALS. Methods: A systematic search was conducted for relevant studies that used voxel-wise analyses of WM microarchitecture in patients with ALS. Anisotropic effect size-signed differential mapping (AES-SDM) was applied to analyze fractional anisotropy (FA) differences between ALS patients and healthy controls. Meta-regression analysis was used to explore the effects of clinical characteristics on WM integrity in patients with ALS. Results: A total of 14 studies with 16 datasets that included 396 patients and 360 healthy controls were identified. The pooled meta-analysis revealed that patients with ALS exhibited significant FA reductions in two clusters relative to healthy controls. The largest cluster exhibited a peak coordinate in the left corona radiata, extending to the body and splenium of the corpus callosum, left superior longitudinal fasciculus, posterior limb of the internal capsule, right corona radiata, and bilateral cingulate gyrus. The other cluster exhibited decreased FA in the right corticospinal tract that extended to the right cerebral peduncle. The Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) score was positively correlated with the FA reduction in the left corona radiata. Mean age and illness duration were not linearly correlated with the FA reductions. Conclusions: This study provides a thorough profile of WM microarchitecture alterations in patients with ALS and further evidence that the neuronal degeneration is not limited to the corticospinal tract but also includes extra-motor areas, which supports the view that ALS is a multisystem degenerative disorder that involves the white matter. SN - 2213-1582 UR - https://www.unboundmedicine.com/medline/citation/30035009/Altered_white_matter_microarchitecture_in_amyotrophic_lateral_sclerosis:_A_voxel_based_meta_analysis_of_diffusion_tensor_imaging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2213-1582(18)30115-3 DB - PRIME DP - Unbound Medicine ER -