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[Methylglucamine antimoniate and sodium stibogluconate in the treatment of leishmaniasis. Study of 16 cases].
Pathol Biol (Paris). 1985 Jun; 33(5 Pt 2):607-10.PB

Abstract

Treatment of visceral and cutaneous leishmaniasis rests on pentavalent antimonial drugs. However, side effects are often a problem and resistance may emerge. N-methyl-glucamine given for kala-azar induced hematologic or hepatic toxicity in three patients and failed in two. Four patients with cutaneous leishmaniasis recovered but two exhibited adverse side effects. Sodium stibo-gluconate failed in one of three kala-azar patients and in one of two patients with cutaneous leishmaniasis. The effects of these two drugs are discussed, as well as indications of pentamidine and splenectomy.

Authors

Bourée P
No affiliation info available
Anciaux ML
No affiliation info available
Taugourdeau P
No affiliation info available

MeSH

AdolescentAdultAntimonyAntimony Sodium GluconateChildChild, PreschoolFemaleGluconatesHumansInfantLeishmaniasisLeishmaniasis, VisceralMaleMeglumineMeglumine AntimoniateOrganometallic CompoundsPentamidineSplenectomy

Pub Type(s)

Journal Article

Language

fre

PubMed ID

3003657

Citation

Bourée, P, et al. "[Methylglucamine Antimoniate and Sodium Stibogluconate in the Treatment of Leishmaniasis. Study of 16 Cases]." Pathologie-biologie, vol. 33, no. 5 Pt 2, 1985, pp. 607-10.
Bourée P, Anciaux ML, Taugourdeau P. [Methylglucamine antimoniate and sodium stibogluconate in the treatment of leishmaniasis. Study of 16 cases]. Pathol Biol (Paris). 1985;33(5 Pt 2):607-10.
Bourée, P., Anciaux, M. L., & Taugourdeau, P. (1985). [Methylglucamine antimoniate and sodium stibogluconate in the treatment of leishmaniasis. Study of 16 cases]. Pathologie-biologie, 33(5 Pt 2), 607-10.
Bourée P, Anciaux ML, Taugourdeau P. [Methylglucamine Antimoniate and Sodium Stibogluconate in the Treatment of Leishmaniasis. Study of 16 Cases]. Pathol Biol (Paris). 1985;33(5 Pt 2):607-10. PubMed PMID: 3003657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Methylglucamine antimoniate and sodium stibogluconate in the treatment of leishmaniasis. Study of 16 cases]. AU - Bourée,P, AU - Anciaux,M L, AU - Taugourdeau,P, PY - 1985/6/1/pubmed PY - 1985/6/1/medline PY - 1985/6/1/entrez SP - 607 EP - 10 JF - Pathologie-biologie JO - Pathol Biol (Paris) VL - 33 IS - 5 Pt 2 N2 - Treatment of visceral and cutaneous leishmaniasis rests on pentavalent antimonial drugs. However, side effects are often a problem and resistance may emerge. N-methyl-glucamine given for kala-azar induced hematologic or hepatic toxicity in three patients and failed in two. Four patients with cutaneous leishmaniasis recovered but two exhibited adverse side effects. Sodium stibo-gluconate failed in one of three kala-azar patients and in one of two patients with cutaneous leishmaniasis. The effects of these two drugs are discussed, as well as indications of pentamidine and splenectomy. SN - 0369-8114 UR - https://www.unboundmedicine.com/medline/citation/3003657/[Methylglucamine_antimoniate_and_sodium_stibogluconate_in_the_treatment_of_leishmaniasis__Study_of_16_cases]_ DB - PRIME DP - Unbound Medicine ER -