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Impact of viral upper respiratory tract infection on the concentration of nasopharyngeal pneumococcal carriage among Kenyan children.
Sci Rep. 2018 07 23; 8(1):11030.SR

Abstract

Viral upper respiratory tract infection (URTI) predisposes to bacterial pneumonia possibly by facilitating growth of bacteria such as Streptococcus pneumoniae colonising the nasopharynx. We investigated whether viral URTI is temporally associated with an increase in nasopharyngeal pneumococcal concentration. Episodes of symptomatic RSV or rhinovirus URTI among children <5 years were identified from a longitudinal household study in rural Kenya. lytA and alu PCR were performed on nasopharyngeal samples collected twice-weekly, to measure the pneumococcal concentration adjusted for the concentration of human DNA present. Pneumococcal concentration increased with a fold-change of 3.80 (95%CI 1.95-7.40), with acquisition of RSV or rhinovirus, during 51 URTI episodes among 42 children. In repeated swabs from the baseline period, in the two weeks before URTI developed, within-episode variation was broad; within +/-112-fold range of the geometric mean. We observed only a small increase in nasopharyngeal pneumococcal concentration during RSV or rhinovirus URTI, relative to natural variation. Other factors, such as host response to viral infection, may be more important than nasopharyngeal pneumococcal concentration in determining risk of invasive disease.

Authors+Show Affiliations

KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya. susan.morpeth@middlemore.co.nz. Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, United Kingdom. susan.morpeth@middlemore.co.nz. Department of Infectious Disease Epidemiology, the London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom. susan.morpeth@middlemore.co.nz. Microbiology Laboratory, Middlemore Hospital, Counties Manukau District Health Board, Private Bag 93311, Otahuhu, Auckland, 1640, New Zealand. susan.morpeth@middlemore.co.nz.KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya.KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 21205, USA.KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya.Department of Infectious Disease Epidemiology, the London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom.KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya. Kenya Medical Research Institute (KEMRI), Centre for Global Health Research; KEMRI - CGHR, Kisumu, Kenya.Department of Pathology, University of Otago, Christchurch, New Zealand. Microbiology Unit, Canterbury Health Laboratories, Christchurch, 8011, New Zealand.KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya. School of Life Sciences and Zeeman Institute (SBIDER), University of Warwick, Coventry, CV4 7AL, United Kingdom.KEMRI-Wellcome Trust Research Programme, Kilifi, 80108, Kenya. Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, United Kingdom. Department of Infectious Disease Epidemiology, the London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30038420

Citation

Morpeth, Susan C., et al. "Impact of Viral Upper Respiratory Tract Infection On the Concentration of Nasopharyngeal Pneumococcal Carriage Among Kenyan Children." Scientific Reports, vol. 8, no. 1, 2018, p. 11030.
Morpeth SC, Munywoki P, Hammitt LL, et al. Impact of viral upper respiratory tract infection on the concentration of nasopharyngeal pneumococcal carriage among Kenyan children. Sci Rep. 2018;8(1):11030.
Morpeth, S. C., Munywoki, P., Hammitt, L. L., Bett, A., Bottomley, C., Onyango, C. O., Murdoch, D. R., Nokes, D. J., & Scott, J. A. G. (2018). Impact of viral upper respiratory tract infection on the concentration of nasopharyngeal pneumococcal carriage among Kenyan children. Scientific Reports, 8(1), 11030. https://doi.org/10.1038/s41598-018-29119-w
Morpeth SC, et al. Impact of Viral Upper Respiratory Tract Infection On the Concentration of Nasopharyngeal Pneumococcal Carriage Among Kenyan Children. Sci Rep. 2018 07 23;8(1):11030. PubMed PMID: 30038420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of viral upper respiratory tract infection on the concentration of nasopharyngeal pneumococcal carriage among Kenyan children. AU - Morpeth,Susan C, AU - Munywoki,Patrick, AU - Hammitt,Laura L, AU - Bett,Anne, AU - Bottomley,Christian, AU - Onyango,Clayton O, AU - Murdoch,David R, AU - Nokes,D James, AU - Scott,J Anthony G, Y1 - 2018/07/23/ PY - 2018/04/23/received PY - 2018/07/02/accepted PY - 2018/7/25/entrez PY - 2018/7/25/pubmed PY - 2019/10/19/medline SP - 11030 EP - 11030 JF - Scientific reports JO - Sci Rep VL - 8 IS - 1 N2 - Viral upper respiratory tract infection (URTI) predisposes to bacterial pneumonia possibly by facilitating growth of bacteria such as Streptococcus pneumoniae colonising the nasopharynx. We investigated whether viral URTI is temporally associated with an increase in nasopharyngeal pneumococcal concentration. Episodes of symptomatic RSV or rhinovirus URTI among children <5 years were identified from a longitudinal household study in rural Kenya. lytA and alu PCR were performed on nasopharyngeal samples collected twice-weekly, to measure the pneumococcal concentration adjusted for the concentration of human DNA present. Pneumococcal concentration increased with a fold-change of 3.80 (95%CI 1.95-7.40), with acquisition of RSV or rhinovirus, during 51 URTI episodes among 42 children. In repeated swabs from the baseline period, in the two weeks before URTI developed, within-episode variation was broad; within +/-112-fold range of the geometric mean. We observed only a small increase in nasopharyngeal pneumococcal concentration during RSV or rhinovirus URTI, relative to natural variation. Other factors, such as host response to viral infection, may be more important than nasopharyngeal pneumococcal concentration in determining risk of invasive disease. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/30038420/Impact_of_viral_upper_respiratory_tract_infection_on_the_concentration_of_nasopharyngeal_pneumococcal_carriage_among_Kenyan_children_ L2 - http://dx.doi.org/10.1038/s41598-018-29119-w DB - PRIME DP - Unbound Medicine ER -