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Biomimetic 3D-printed custom-made prosthesis for anterior column reconstruction in the thoracolumbar spine: a tailored option following en bloc resection for spinal tumors : Preliminary results on a case-series of 13 patients.
Eur Spine J. 2018 12; 27(12):3073-3083.ES

Abstract

PURPOSE

Various techniques for anterior column reconstruction have been described after en bloc resection of spinal tumors. Limited evidence exists regarding one being superior to another. The purpose of this study is to evaluate 3D-printed vertebral bodies for spinal reconstruction after en bloc resection in the thoracolumbar spine.

METHODS

Prospective observational study on custom-made 3D-printed titanium reconstruction of vertebral bodies after en bloc resection for spinal tumor was conducted between November 2015 and June 2017. 3D-printed vertebral bodies were monitored for mechanical complications such as (1) migration, (2) subsidence into the adjacent vertebral bodies, and/or (3) breakage. Complications and related details were recorded.

RESULTS

Thirteen patients (7 females and 6 males) were enrolled, and reconstruction of the anterior column was performed using custom-made 3D-printed titanium prosthesis after en bloc resection for spinal tumor (8 primary bone tumors and 5 solitary metastases). Subsidence into the adjacent vertebral bodies occurred in all patients at both proximal and distal bone-implant interfaces; however, it was clinically irrelevant (asymptomatic, and no consequences on posterior instrumentation), in 11 out of 12 patients (92%). In 1 patient (#4), severity of the subsidence led to revision of the construct. At an average 10-month follow-up (range 2-16), 1 implant was removed due to local recurrence of the disease and 1 was revisioned due to progressive distal junctional kyphosis.

CONCLUSION

Preliminary results from this series suggest that 3D printing can be effectively used to produce custom-made prosthesis for anterior column reconstruction. These slides can be retrieved under Electronic Supplementary Material.

Authors+Show Affiliations

Department of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1, 40136, Bologna, Italy. marco.girolami@yahoo.it.IRCCS Galeazzi Orthopedic Institute, Milan, Italy.Department of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1, 40136, Bologna, Italy.Department of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1, 40136, Bologna, Italy.Department of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1, 40136, Bologna, Italy.Department of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1, 40136, Bologna, Italy.Department of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1, 40136, Bologna, Italy.Department of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1, 40136, Bologna, Italy.Department of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1, 40136, Bologna, Italy.Department of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1, 40136, Bologna, Italy.

Pub Type(s)

Journal Article
Observational Study
Video-Audio Media

Language

eng

PubMed ID

30039254

Citation

Girolami, Marco, et al. "Biomimetic 3D-printed Custom-made Prosthesis for Anterior Column Reconstruction in the Thoracolumbar Spine: a Tailored Option Following En Bloc Resection for Spinal Tumors : Preliminary Results On a Case-series of 13 Patients." European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, vol. 27, no. 12, 2018, pp. 3073-3083.
Girolami M, Boriani S, Bandiera S, et al. Biomimetic 3D-printed custom-made prosthesis for anterior column reconstruction in the thoracolumbar spine: a tailored option following en bloc resection for spinal tumors : Preliminary results on a case-series of 13 patients. Eur Spine J. 2018;27(12):3073-3083.
Girolami, M., Boriani, S., Bandiera, S., Barbanti-Bródano, G., Ghermandi, R., Terzi, S., Tedesco, G., Evangelisti, G., Pipola, V., & Gasbarrini, A. (2018). Biomimetic 3D-printed custom-made prosthesis for anterior column reconstruction in the thoracolumbar spine: a tailored option following en bloc resection for spinal tumors : Preliminary results on a case-series of 13 patients. European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 27(12), 3073-3083. https://doi.org/10.1007/s00586-018-5708-8
Girolami M, et al. Biomimetic 3D-printed Custom-made Prosthesis for Anterior Column Reconstruction in the Thoracolumbar Spine: a Tailored Option Following En Bloc Resection for Spinal Tumors : Preliminary Results On a Case-series of 13 Patients. Eur Spine J. 2018;27(12):3073-3083. PubMed PMID: 30039254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomimetic 3D-printed custom-made prosthesis for anterior column reconstruction in the thoracolumbar spine: a tailored option following en bloc resection for spinal tumors : Preliminary results on a case-series of 13 patients. AU - Girolami,Marco, AU - Boriani,Stefano, AU - Bandiera,Stefano, AU - Barbanti-Bródano,Giovanni, AU - Ghermandi,Riccardo, AU - Terzi,Silvia, AU - Tedesco,Giuseppe, AU - Evangelisti,Gisberto, AU - Pipola,Valerio, AU - Gasbarrini,Alessandro, Y1 - 2018/07/23/ PY - 2017/11/21/received PY - 2018/07/18/accepted PY - 2018/7/25/pubmed PY - 2019/10/29/medline PY - 2018/7/25/entrez KW - 3D printing KW - En bloc resection KW - Metastases KW - Primary bone tumor KW - Spinal reconstruction KW - Spinal tumors KW - Spine surgery SP - 3073 EP - 3083 JF - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JO - Eur Spine J VL - 27 IS - 12 N2 - PURPOSE: Various techniques for anterior column reconstruction have been described after en bloc resection of spinal tumors. Limited evidence exists regarding one being superior to another. The purpose of this study is to evaluate 3D-printed vertebral bodies for spinal reconstruction after en bloc resection in the thoracolumbar spine. METHODS: Prospective observational study on custom-made 3D-printed titanium reconstruction of vertebral bodies after en bloc resection for spinal tumor was conducted between November 2015 and June 2017. 3D-printed vertebral bodies were monitored for mechanical complications such as (1) migration, (2) subsidence into the adjacent vertebral bodies, and/or (3) breakage. Complications and related details were recorded. RESULTS: Thirteen patients (7 females and 6 males) were enrolled, and reconstruction of the anterior column was performed using custom-made 3D-printed titanium prosthesis after en bloc resection for spinal tumor (8 primary bone tumors and 5 solitary metastases). Subsidence into the adjacent vertebral bodies occurred in all patients at both proximal and distal bone-implant interfaces; however, it was clinically irrelevant (asymptomatic, and no consequences on posterior instrumentation), in 11 out of 12 patients (92%). In 1 patient (#4), severity of the subsidence led to revision of the construct. At an average 10-month follow-up (range 2-16), 1 implant was removed due to local recurrence of the disease and 1 was revisioned due to progressive distal junctional kyphosis. CONCLUSION: Preliminary results from this series suggest that 3D printing can be effectively used to produce custom-made prosthesis for anterior column reconstruction. These slides can be retrieved under Electronic Supplementary Material. SN - 1432-0932 UR - https://www.unboundmedicine.com/medline/citation/30039254/Biomimetic_3D_printed_custom_made_prosthesis_for_anterior_column_reconstruction_in_the_thoracolumbar_spine:_a_tailored_option_following_en_bloc_resection_for_spinal_tumors_:_Preliminary_results_on_a_case_series_of_13_patients_ L2 - https://doi.org/10.1007/s00586-018-5708-8 DB - PRIME DP - Unbound Medicine ER -