Tags

Type your tag names separated by a space and hit enter

Protein Energy Wasting and Sarcopenia in Dialysis Patients.
Contrib Nephrol. 2018; 196:243-249.CN

Abstract

As the aging of the population progresses in Japan, the nutritional problems in dialysis patients are being highlighted. Frailty is a clinical concept including body weight loss, muscle weakness, fatigability, decreased walking speed, and decreased physical activity, which means an intermediate concept between healthy subjects and disability subjects, indicating that their activities of daily living are not decreased but they cannot smoothly perform housework or exercise. Morbidity of dialysis patients is known to be high, and mortality of dialysis patients with frailty is 3 times higher. Sarcopenia is one of the principal reasons for or triggers of frailty. It is a disease setting showing decreased muscle volume and quality associated with decreased physical function or quality of life. Recent mean age at dialysis therapy induction is getting near to 70 years old in Japan. Japanese dialysis patients who are elderly and present organ failure would have a double risk for sarcopenia. Patients with advanced stages of CKD are generally given protein diet, and it has been reported that a low protein intake in dialysis patients would be a significant risk for developing sarcopenia and increasing mortality. Recently, the focus has been on protein energy wasting (PEW) - an underlying disease condition in sarcopenia or frailty. PEW is an energy wasting condition occurring in dialysis patients, and the cause of PEW is principally decreased food intake and increased catabolism. It has recently been revealed that decreased protein intake would be a risk factor for increased mortality in dialysis patients. The incidence of PEW in dialysis patients is reported to be 14%. To avoid sarcopenia and PEW leading to frailty, we should pay much more attention to an appropriate protein and calorie intake rather than restriction in dialysis patients.

Links

Publisher Full Text (DOI)

Authors

Hara H
No affiliation info available
Nakamura Y
No affiliation info available
Hatano M
No affiliation info available
Iwashita T
No affiliation info available
Shimizu T
No affiliation info available
Ogawa T
No affiliation info available
Kanozawa K
No affiliation info available
Hasegawa H
No affiliation info available

MeSH

Activities of Daily LivingAgedAgingDietHumansNutritional StatusProtein-Energy MalnutritionQuality of LifeRenal DialysisSarcopenia

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30041234

Citation

Hara, Hiroaki, et al. "Protein Energy Wasting and Sarcopenia in Dialysis Patients." Contributions to Nephrology, vol. 196, 2018, pp. 243-249.
Hara H, Nakamura Y, Hatano M, et al. Protein Energy Wasting and Sarcopenia in Dialysis Patients. Contrib Nephrol. 2018;196:243-249.
Hara, H., Nakamura, Y., Hatano, M., Iwashita, T., Shimizu, T., Ogawa, T., Kanozawa, K., & Hasegawa, H. (2018). Protein Energy Wasting and Sarcopenia in Dialysis Patients. Contributions to Nephrology, 196, 243-249. https://doi.org/10.1159/000485729
Hara H, et al. Protein Energy Wasting and Sarcopenia in Dialysis Patients. Contrib Nephrol. 2018;196:243-249. PubMed PMID: 30041234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protein Energy Wasting and Sarcopenia in Dialysis Patients. AU - Hara,Hiroaki, AU - Nakamura,Yumiko, AU - Hatano,Minoru, AU - Iwashita,Takatsugu, AU - Shimizu,Taisuke, AU - Ogawa,Tomonari, AU - Kanozawa,Koichi, AU - Hasegawa,Hajime, Y1 - 2018/07/24/ PY - 2018/7/25/entrez PY - 2018/7/25/pubmed PY - 2019/8/3/medline SP - 243 EP - 249 JF - Contributions to nephrology JO - Contrib Nephrol VL - 196 N2 - As the aging of the population progresses in Japan, the nutritional problems in dialysis patients are being highlighted. Frailty is a clinical concept including body weight loss, muscle weakness, fatigability, decreased walking speed, and decreased physical activity, which means an intermediate concept between healthy subjects and disability subjects, indicating that their activities of daily living are not decreased but they cannot smoothly perform housework or exercise. Morbidity of dialysis patients is known to be high, and mortality of dialysis patients with frailty is 3 times higher. Sarcopenia is one of the principal reasons for or triggers of frailty. It is a disease setting showing decreased muscle volume and quality associated with decreased physical function or quality of life. Recent mean age at dialysis therapy induction is getting near to 70 years old in Japan. Japanese dialysis patients who are elderly and present organ failure would have a double risk for sarcopenia. Patients with advanced stages of CKD are generally given protein diet, and it has been reported that a low protein intake in dialysis patients would be a significant risk for developing sarcopenia and increasing mortality. Recently, the focus has been on protein energy wasting (PEW) - an underlying disease condition in sarcopenia or frailty. PEW is an energy wasting condition occurring in dialysis patients, and the cause of PEW is principally decreased food intake and increased catabolism. It has recently been revealed that decreased protein intake would be a risk factor for increased mortality in dialysis patients. The incidence of PEW in dialysis patients is reported to be 14%. To avoid sarcopenia and PEW leading to frailty, we should pay much more attention to an appropriate protein and calorie intake rather than restriction in dialysis patients. SN - 1662-2782 UR - https://www.unboundmedicine.com/medline/citation/30041234/Protein_Energy_Wasting_and_Sarcopenia_in_Dialysis_Patients_ DB - PRIME DP - Unbound Medicine ER -