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Antagonistic effects of Spirulina platensis on diazinon-induced hemato-biochemical alterations and oxidative stress in rats.
Environ Sci Pollut Res Int. 2018 Sep; 25(27):27463-27470.ES

Abstract

Spirulina platensis (SP) is a traditionally used microalga for a wide range of pharmacological activities, including amelioration of heavy metals and pesticides toxicity. This study evaluated the antioxidant and organoprotective effects of SP against diazinon (DZN)-induced subacute toxicity on the blood, heart, liver, and kidneys of male Wistar albino rats. Diazinon (20 mg/kg, subcutaneous) was administered to animals either alone or along with an oral pure SP powder at doses of 500 and 1000 mg/kg. Alterations in hematological and serum biochemical parameters, as well as oxidative stress markers in the hepatic, renal, and cardiac tissues were evaluated, using colorimetric spectrophotometric techniques. The obtained results revealed that in comparison to the control group, DZN-treated rats exhibited significantly lower (p < 0.05) red blood cells and platelets counts, hemoglobin and hematocrit values, and activities of serum acetylcholinesterase and tissue antioxidant enzymes (glutathione peroxidase, superoxide dismutase, and catalase). Meanwhile, biochemical analysis showed significantly higher (p < 0.05) white blood cells count, serum concentrations of tumor necrosis factor-α and cardiac [creatine kinase (CK) and CK-muscle/brain fraction], hepatic [transaminases and alkaline phosphatase], and renal [uric acid, urea and creatinine] injury markers, and tissue levels of malondialdehyde (a marker of lipid peroxidation) in the DZN-intoxicated group, compared to normal controls. Interestingly, the administration of SP significantly ameliorated the previous hemato-biochemical alterations and mitigated DZN-induced organ injuries and oxidative stress. In conclusion, the natural antioxidant microalga (SP) effectively alleviated the DZN-induced hematologic alterations and organ injuries, probably through its antioxidant and anti-inflammatory activities.

Authors+Show Affiliations

Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt. Abdeldaim.m@vet.suez.edu.eg.Faculty of Medicine, Ain Shams University, Cairo, Egypt.Biochemistry Department, Faculty of Science, Al Faisaliah King Abdulaziz University, Jeddah, Saudi Arabia.Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt. Center of Excellence of Molecular and Cellular Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt. Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.College of Pharmacy, Government College University, Faisalabad, Pakistan.Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, 25030 11, Besançon Cedex, France.Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30043347

Citation

Abdel-Daim, Mohamed M., et al. "Antagonistic Effects of Spirulina Platensis On Diazinon-induced Hemato-biochemical Alterations and Oxidative Stress in Rats." Environmental Science and Pollution Research International, vol. 25, no. 27, 2018, pp. 27463-27470.
Abdel-Daim MM, Abushouk AI, Alkhalf MI, et al. Antagonistic effects of Spirulina platensis on diazinon-induced hemato-biochemical alterations and oxidative stress in rats. Environ Sci Pollut Res Int. 2018;25(27):27463-27470.
Abdel-Daim, M. M., Abushouk, A. I., Alkhalf, M. I., Toraih, E. A., Fawzy, M. S., Ijaz, H., Aleya, L., & Bungau, S. G. (2018). Antagonistic effects of Spirulina platensis on diazinon-induced hemato-biochemical alterations and oxidative stress in rats. Environmental Science and Pollution Research International, 25(27), 27463-27470. https://doi.org/10.1007/s11356-018-2761-0
Abdel-Daim MM, et al. Antagonistic Effects of Spirulina Platensis On Diazinon-induced Hemato-biochemical Alterations and Oxidative Stress in Rats. Environ Sci Pollut Res Int. 2018;25(27):27463-27470. PubMed PMID: 30043347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antagonistic effects of Spirulina platensis on diazinon-induced hemato-biochemical alterations and oxidative stress in rats. AU - Abdel-Daim,Mohamed M, AU - Abushouk,Abdelrahman Ibrahim, AU - Alkhalf,Maha I, AU - Toraih,Eman A, AU - Fawzy,Manal S, AU - Ijaz,Hira, AU - Aleya,Lotfi, AU - Bungau,Simona G, Y1 - 2018/07/25/ PY - 2018/03/16/received PY - 2018/07/13/accepted PY - 2018/7/26/pubmed PY - 2019/1/4/medline PY - 2018/7/26/entrez KW - Diazinon KW - Heart KW - Kidneys KW - Liver KW - Oxidative stress KW - Spirulina platensis SP - 27463 EP - 27470 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 25 IS - 27 N2 - Spirulina platensis (SP) is a traditionally used microalga for a wide range of pharmacological activities, including amelioration of heavy metals and pesticides toxicity. This study evaluated the antioxidant and organoprotective effects of SP against diazinon (DZN)-induced subacute toxicity on the blood, heart, liver, and kidneys of male Wistar albino rats. Diazinon (20 mg/kg, subcutaneous) was administered to animals either alone or along with an oral pure SP powder at doses of 500 and 1000 mg/kg. Alterations in hematological and serum biochemical parameters, as well as oxidative stress markers in the hepatic, renal, and cardiac tissues were evaluated, using colorimetric spectrophotometric techniques. The obtained results revealed that in comparison to the control group, DZN-treated rats exhibited significantly lower (p < 0.05) red blood cells and platelets counts, hemoglobin and hematocrit values, and activities of serum acetylcholinesterase and tissue antioxidant enzymes (glutathione peroxidase, superoxide dismutase, and catalase). Meanwhile, biochemical analysis showed significantly higher (p < 0.05) white blood cells count, serum concentrations of tumor necrosis factor-α and cardiac [creatine kinase (CK) and CK-muscle/brain fraction], hepatic [transaminases and alkaline phosphatase], and renal [uric acid, urea and creatinine] injury markers, and tissue levels of malondialdehyde (a marker of lipid peroxidation) in the DZN-intoxicated group, compared to normal controls. Interestingly, the administration of SP significantly ameliorated the previous hemato-biochemical alterations and mitigated DZN-induced organ injuries and oxidative stress. In conclusion, the natural antioxidant microalga (SP) effectively alleviated the DZN-induced hematologic alterations and organ injuries, probably through its antioxidant and anti-inflammatory activities. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/30043347/Antagonistic_effects_of_Spirulina_platensis_on_diazinon_induced_hemato_biochemical_alterations_and_oxidative_stress_in_rats_ DB - PRIME DP - Unbound Medicine ER -