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SEROLOGICAL SCREENING FOR CELIAC DISEASE IN CHILDREN WITH COLCHICINE-RESISTANT FAMILIAL MEDITERRANEAN FEVER.
Arq Gastroenterol 2018 Apr-Jun; 55(2):175-178AG

Abstract

BACKGROUND

Familial Mediterranean fever and celiac disease share some common clinical features such as abdominal pain, diarrhea, arthralgia and arthritis. Also, both of the diseases are associated with many inflammatory and autoimmune diseases. Previous studies have shown the association between familial Mediterranean fever (FMF) and different clinical conditions.

OBJECTIVE

We aimed to investigate the relationship between celiac disease and colchicine-resistant familial Mediterranean fever (crFMF) disease.

METHODS

This prospective study was conducted at the Department of Pediatric Gastroenterology and Pediatric Rheumatology from October 2015 to August 2016. A total of 24 patients with crFMF were included in the study. We used 60 sex- and age-matched healthy subjects as a control group. Levels of total IgA and tissue transglutaminase (tTG) IgA antibody were measured in both groups. Those with increased level of tTG IgA were tested for anti-endomysium IgA antibodies (EMA). Gastroduodenoscopy and intestinal biopsy were planned for a definite diagnosis of celiac disease in patients with positive EMA.

RESULTS

Of the 24 patients in this study, 18 (75.0%) were female. Only 4 (16.6%) of 24 patients were positive for tTG IgA. Patients with positive tTG IgA were then tested for EMA IgA antibodies and none of them had a positive result. Only one (1.6%) subject from the control group was positive for tTG IgA but EMA positivity was not detected.

CONCLUSION

We did not found celiac disease in 24 children with crFMF. Since crFMF disease is rarely seen in general population, further studies with more patients are needed to provide more precise interpretation.

Authors+Show Affiliations

Istanbul University, Cerrahpasa Medical School, Department of Pediatric Gastroenterology, Turkey.Istanbul University, Cerrahpasa Medical School, Pediatric Rheumatology, Turkey.Istanbul University, Cerrahpasa Medical School, Department of Pediatric Gastroenterology, Turkey.Istanbul University, Cerrahpasa Medical School, Department of Pediatric Gastroenterology, Turkey.Istanbul University, Cerrahpasa Medical School, Pediatric Rheumatology, Turkey.Istanbul University, Cerrahpasa Medical School, Pediatric Rheumatology, Turkey.Istanbul University, Cerrahpasa Medical School, Department of Pediatric Gastroenterology, Turkey.Istanbul University, Cerrahpasa Medical School, Pediatric Rheumatology, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30043869

Citation

Şahin, Yasin, et al. "SEROLOGICAL SCREENING for CELIAC DISEASE in CHILDREN WITH COLCHICINE-RESISTANT FAMILIAL MEDITERRANEAN FEVER." Arquivos De Gastroenterologia, vol. 55, no. 2, 2018, pp. 175-178.
Şahin Y, Barut K, Kutlu T, et al. SEROLOGICAL SCREENING FOR CELIAC DISEASE IN CHILDREN WITH COLCHICINE-RESISTANT FAMILIAL MEDITERRANEAN FEVER. Arq Gastroenterol. 2018;55(2):175-178.
Şahin, Y., Barut, K., Kutlu, T., Cokugras, F. C., Adrovic, A., Sahin, S., ... Kasapcopur, O. (2018). SEROLOGICAL SCREENING FOR CELIAC DISEASE IN CHILDREN WITH COLCHICINE-RESISTANT FAMILIAL MEDITERRANEAN FEVER. Arquivos De Gastroenterologia, 55(2), pp. 175-178. doi:10.1590/S0004-2803.201800000-31.
Şahin Y, et al. SEROLOGICAL SCREENING for CELIAC DISEASE in CHILDREN WITH COLCHICINE-RESISTANT FAMILIAL MEDITERRANEAN FEVER. Arq Gastroenterol. 2018;55(2):175-178. PubMed PMID: 30043869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SEROLOGICAL SCREENING FOR CELIAC DISEASE IN CHILDREN WITH COLCHICINE-RESISTANT FAMILIAL MEDITERRANEAN FEVER. AU - Şahin,Yasin, AU - Barut,Kenan, AU - Kutlu,Tufan, AU - Cokugras,Fugen Cullu, AU - Adrovic,Amra, AU - Sahin,Sezgin, AU - Erkan,Tulay, AU - Kasapcopur,Ozgur, PY - 2017/09/06/received PY - 2018/01/09/accepted PY - 2018/7/26/entrez PY - 2018/7/26/pubmed PY - 2018/9/7/medline SP - 175 EP - 178 JF - Arquivos de gastroenterologia JO - Arq Gastroenterol VL - 55 IS - 2 N2 - BACKGROUND: Familial Mediterranean fever and celiac disease share some common clinical features such as abdominal pain, diarrhea, arthralgia and arthritis. Also, both of the diseases are associated with many inflammatory and autoimmune diseases. Previous studies have shown the association between familial Mediterranean fever (FMF) and different clinical conditions. OBJECTIVE: We aimed to investigate the relationship between celiac disease and colchicine-resistant familial Mediterranean fever (crFMF) disease. METHODS: This prospective study was conducted at the Department of Pediatric Gastroenterology and Pediatric Rheumatology from October 2015 to August 2016. A total of 24 patients with crFMF were included in the study. We used 60 sex- and age-matched healthy subjects as a control group. Levels of total IgA and tissue transglutaminase (tTG) IgA antibody were measured in both groups. Those with increased level of tTG IgA were tested for anti-endomysium IgA antibodies (EMA). Gastroduodenoscopy and intestinal biopsy were planned for a definite diagnosis of celiac disease in patients with positive EMA. RESULTS: Of the 24 patients in this study, 18 (75.0%) were female. Only 4 (16.6%) of 24 patients were positive for tTG IgA. Patients with positive tTG IgA were then tested for EMA IgA antibodies and none of them had a positive result. Only one (1.6%) subject from the control group was positive for tTG IgA but EMA positivity was not detected. CONCLUSION: We did not found celiac disease in 24 children with crFMF. Since crFMF disease is rarely seen in general population, further studies with more patients are needed to provide more precise interpretation. SN - 1678-4219 UR - https://www.unboundmedicine.com/medline/citation/30043869/SEROLOGICAL_SCREENING_FOR_CELIAC_DISEASE_IN_CHILDREN_WITH_COLCHICINE_RESISTANT_FAMILIAL_MEDITERRANEAN_FEVER_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018000200175&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -