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ULTRA-WIDEFIELD MULTIMODAL IMAGING OF PRIMARY VITREORETINAL LYMPHOMA.
Retina. 2019 Oct; 39(10):1861-1871.R

Abstract

PURPOSE

To determine the features of primary vitreoretinal lymphoma on multimodal ultra-widefield imaging and correlate these findings to clinical outcomes.

METHODS

We report a retrospective, observational case series of 43 eyes of 23 patients with biopsy-proven B-cell primary vitreoretinal lymphoma. Fundus photography, fluorescein angiography (FA), optical coherence tomography, fundus autofluorescence, and indocyanine green angiography images were reviewed. Medical records were assessed for the central nervous system involvement and visual acuity outcomes at 6 and 12 months after presentation.

RESULTS

Common fundus photography findings were sub-retinal pigment epithelium lesions and vitritis alone. Common ultra-widefield FA findings were vascular leakage and scleral staining. Retinal optical coherence tomography features overlying sub-retinal pigment epithelium lesions or within the macula predicted fluorescence patterns. The presence of retinal fluid or disorganization associated with hyperfluorescence and late leakage. Normal retinal structures associated with hypofluorescence of sub-retinal pigment epithelium lesions or macular leopard spotting on FA and fundus autofluorescence. Peripheral abnormalities noted on ultra-widefield fundus photography, FA, and indocyanine green angiography were more frequent than posterior pole abnormalities. No imaging characteristics predicted time to the central nervous system progression.

CONCLUSION

Ultra-widefield imaging was more informative than posterior pole imaging in fundus photography, FA, and indocyanine green angiography. Common findings on multimodal ultra-widefield imaging may lead to early diagnostic vitrectomy and may reduce the delay in primary vitreoretinal lymphoma diagnosis.

Authors+Show Affiliations

Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

30044267

Citation

Lavine, Jeremy A., et al. "ULTRA-WIDEFIELD MULTIMODAL IMAGING of PRIMARY VITREORETINAL LYMPHOMA." Retina (Philadelphia, Pa.), vol. 39, no. 10, 2019, pp. 1861-1871.
Lavine JA, Singh AD, Sharma S, et al. ULTRA-WIDEFIELD MULTIMODAL IMAGING OF PRIMARY VITREORETINAL LYMPHOMA. Retina. 2019;39(10):1861-1871.
Lavine, J. A., Singh, A. D., Sharma, S., Baynes, K., Lowder, C. Y., & Srivastava, S. K. (2019). ULTRA-WIDEFIELD MULTIMODAL IMAGING OF PRIMARY VITREORETINAL LYMPHOMA. Retina (Philadelphia, Pa.), 39(10), 1861-1871. https://doi.org/10.1097/IAE.0000000000002260
Lavine JA, et al. ULTRA-WIDEFIELD MULTIMODAL IMAGING of PRIMARY VITREORETINAL LYMPHOMA. Retina. 2019;39(10):1861-1871. PubMed PMID: 30044267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ULTRA-WIDEFIELD MULTIMODAL IMAGING OF PRIMARY VITREORETINAL LYMPHOMA. AU - Lavine,Jeremy A, AU - Singh,Arun D, AU - Sharma,Sumit, AU - Baynes,Kimberly, AU - Lowder,Careen Y, AU - Srivastava,Sunil K, PY - 2018/7/26/pubmed PY - 2020/11/13/medline PY - 2018/7/26/entrez SP - 1861 EP - 1871 JF - Retina (Philadelphia, Pa.) JO - Retina VL - 39 IS - 10 N2 - PURPOSE: To determine the features of primary vitreoretinal lymphoma on multimodal ultra-widefield imaging and correlate these findings to clinical outcomes. METHODS: We report a retrospective, observational case series of 43 eyes of 23 patients with biopsy-proven B-cell primary vitreoretinal lymphoma. Fundus photography, fluorescein angiography (FA), optical coherence tomography, fundus autofluorescence, and indocyanine green angiography images were reviewed. Medical records were assessed for the central nervous system involvement and visual acuity outcomes at 6 and 12 months after presentation. RESULTS: Common fundus photography findings were sub-retinal pigment epithelium lesions and vitritis alone. Common ultra-widefield FA findings were vascular leakage and scleral staining. Retinal optical coherence tomography features overlying sub-retinal pigment epithelium lesions or within the macula predicted fluorescence patterns. The presence of retinal fluid or disorganization associated with hyperfluorescence and late leakage. Normal retinal structures associated with hypofluorescence of sub-retinal pigment epithelium lesions or macular leopard spotting on FA and fundus autofluorescence. Peripheral abnormalities noted on ultra-widefield fundus photography, FA, and indocyanine green angiography were more frequent than posterior pole abnormalities. No imaging characteristics predicted time to the central nervous system progression. CONCLUSION: Ultra-widefield imaging was more informative than posterior pole imaging in fundus photography, FA, and indocyanine green angiography. Common findings on multimodal ultra-widefield imaging may lead to early diagnostic vitrectomy and may reduce the delay in primary vitreoretinal lymphoma diagnosis. SN - 1539-2864 UR - https://www.unboundmedicine.com/medline/citation/30044267/ULTRA_WIDEFIELD_MULTIMODAL_IMAGING_OF_PRIMARY_VITREORETINAL_LYMPHOMA_ L2 - https://doi.org/10.1097/IAE.0000000000002260 DB - PRIME DP - Unbound Medicine ER -