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Effect of ascorbic acid rich, micro-nutrient fortified supplement on the iron bioavailability of ferric pyrophosphate from a milk based beverage in Indian school children.
Asia Pac J Clin Nutr. 2018; 27(4):792-796.AP

Abstract

BACKGROUND AND OBJECTIVES

Nutritional anemia is a significant public health issue with 50-80% prevalence in Indian children. Fortification of food, specifically milk, with iron is a potential approach to increase dietary iron intake. Ferric pyrophosphate [Fe4(P2O7)3] is organoleptically neutral and is less soluble in acid medium and, further, has low bioavailability in milk. However, since ascorbic acid is a potent enhancer of iron absorption, the coadministration of ascorbic acid with Fe4(P2O7)3 might enhance the absorption of iron. We evaluated the effect of ascorbic acid on iron absorption from a Fe4(P2O7)3 and an ascorbic acid fortified milk beverage with respect to milk fortified with Fe4(P2O7)3 alone.

METHODS AND STUDY DESIGN

A double-blind, two-way crossover, randomized study was conducted in 25 mildly anemic children. The test group received milk fortified with beverage powder containing 7 mg isotopically labeled iron (57Fe/58Fe) as Fe4(P2O7)3, equimolar proportions of ascorbic acid and 200 mg of calcium whereas control group received milk fortified with energy, calcium and iron equivalent beverage powder. Fractional iron absorption was measured by erythrocyte incorporation of stable isotopes of iron (57Fe/58Fe) in both the groups.

RESULTS

The fractional iron absorption from the control drink was 0.80% (95% CI: 0.57, 1.12). Fortifying the milk with an equimolar amount of ascorbic acid increased the fractional iron absorption almost 2-fold to 1.58% (95% CI: 1.13, 2.22).

CONCLUSIONS

The presence of ascorbic acid in an equimolar ratio with that of iron from Fe4(P2O7)3 salt in milk as a fortificant enhanced iron absorption when compared to milk fortified with only Fe4(P2O7)3.

Authors+Show Affiliations

Department of Physiology, St John's Medical College, Bangalore, India.Department of Physiology, St John's Medical College, Bangalore, India. sejil.tv@stjohns.in.Clinical Proteomics Unit, Division of Molecular Medicine, St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India.St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India.St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India.Clinical Proteomics Unit, Division of Molecular Medicine, St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India.St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India.Department of Physiology, St John's Medical College, Bangalore, India. St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30045423

Citation

Pauline, Maria, et al. "Effect of Ascorbic Acid Rich, Micro-nutrient Fortified Supplement On the Iron Bioavailability of Ferric Pyrophosphate From a Milk Based Beverage in Indian School Children." Asia Pacific Journal of Clinical Nutrition, vol. 27, no. 4, 2018, pp. 792-796.
Pauline M, Verghese ST, Srinivasu BY, et al. Effect of ascorbic acid rich, micro-nutrient fortified supplement on the iron bioavailability of ferric pyrophosphate from a milk based beverage in Indian school children. Asia Pac J Clin Nutr. 2018;27(4):792-796.
Pauline, M., Verghese, S. T., Srinivasu, B. Y., Bose, B., Thomas, T., Mandal, A. K., Thankachan, P., & Kurpad, A. V. (2018). Effect of ascorbic acid rich, micro-nutrient fortified supplement on the iron bioavailability of ferric pyrophosphate from a milk based beverage in Indian school children. Asia Pacific Journal of Clinical Nutrition, 27(4), 792-796. https://doi.org/10.6133/apjcn.092017.07
Pauline M, et al. Effect of Ascorbic Acid Rich, Micro-nutrient Fortified Supplement On the Iron Bioavailability of Ferric Pyrophosphate From a Milk Based Beverage in Indian School Children. Asia Pac J Clin Nutr. 2018;27(4):792-796. PubMed PMID: 30045423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ascorbic acid rich, micro-nutrient fortified supplement on the iron bioavailability of ferric pyrophosphate from a milk based beverage in Indian school children. AU - Pauline,Maria, AU - Verghese,Sejil T, AU - Srinivasu,Bindu Y, AU - Bose,Beena, AU - Thomas,Tinku, AU - Mandal,Amit K, AU - Thankachan,Prashanth, AU - Kurpad,Anura V, PY - 2018/7/26/entrez PY - 2018/7/27/pubmed PY - 2019/9/10/medline SP - 792 EP - 796 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 27 IS - 4 N2 - BACKGROUND AND OBJECTIVES: Nutritional anemia is a significant public health issue with 50-80% prevalence in Indian children. Fortification of food, specifically milk, with iron is a potential approach to increase dietary iron intake. Ferric pyrophosphate [Fe4(P2O7)3] is organoleptically neutral and is less soluble in acid medium and, further, has low bioavailability in milk. However, since ascorbic acid is a potent enhancer of iron absorption, the coadministration of ascorbic acid with Fe4(P2O7)3 might enhance the absorption of iron. We evaluated the effect of ascorbic acid on iron absorption from a Fe4(P2O7)3 and an ascorbic acid fortified milk beverage with respect to milk fortified with Fe4(P2O7)3 alone. METHODS AND STUDY DESIGN: A double-blind, two-way crossover, randomized study was conducted in 25 mildly anemic children. The test group received milk fortified with beverage powder containing 7 mg isotopically labeled iron (57Fe/58Fe) as Fe4(P2O7)3, equimolar proportions of ascorbic acid and 200 mg of calcium whereas control group received milk fortified with energy, calcium and iron equivalent beverage powder. Fractional iron absorption was measured by erythrocyte incorporation of stable isotopes of iron (57Fe/58Fe) in both the groups. RESULTS: The fractional iron absorption from the control drink was 0.80% (95% CI: 0.57, 1.12). Fortifying the milk with an equimolar amount of ascorbic acid increased the fractional iron absorption almost 2-fold to 1.58% (95% CI: 1.13, 2.22). CONCLUSIONS: The presence of ascorbic acid in an equimolar ratio with that of iron from Fe4(P2O7)3 salt in milk as a fortificant enhanced iron absorption when compared to milk fortified with only Fe4(P2O7)3. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/30045423/Effect_of_ascorbic_acid_rich_micro_nutrient_fortified_supplement_on_the_iron_bioavailability_of_ferric_pyrophosphate_from_a_milk_based_beverage_in_Indian_school_children_ L2 - http://apjcn.nhri.org.tw/server/APJCN/27/4/792.pdf DB - PRIME DP - Unbound Medicine ER -