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Gene editing in human development: ethical concerns and practical applications.
Development. 2018 07 25; 145(16)D

Abstract

The amazing power of CRISPR-Cas9 gene editing tools and other related technologies has impacted all areas of biology today. It has also raised ethical concerns, particularly with regard to the possibility of generating heritable changes in the human genome - so-called germline gene editing. Although technical and safety issues suggest that this approach is far from clinical application, gene editing as a research tool is moving forward in human embryos, non-human primates and in stem cell-derived embryoids. These studies are already providing new information relevant to our understanding of normal human development, infertility, early pregnancy loss and pluripotent stem cell origins.

Authors+Show Affiliations

Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5G 0A4 janet.rossant@sickkids.ca.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30045910

Citation

Rossant, Janet. "Gene Editing in Human Development: Ethical Concerns and Practical Applications." Development (Cambridge, England), vol. 145, no. 16, 2018.
Rossant J. Gene editing in human development: ethical concerns and practical applications. Development. 2018;145(16).
Rossant, J. (2018). Gene editing in human development: ethical concerns and practical applications. Development (Cambridge, England), 145(16). https://doi.org/10.1242/dev.150888
Rossant J. Gene Editing in Human Development: Ethical Concerns and Practical Applications. Development. 2018 07 25;145(16) PubMed PMID: 30045910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene editing in human development: ethical concerns and practical applications. A1 - Rossant,Janet, Y1 - 2018/07/25/ PY - 2018/7/27/entrez PY - 2018/7/27/pubmed PY - 2018/8/29/medline JF - Development (Cambridge, England) JO - Development VL - 145 IS - 16 N2 - The amazing power of CRISPR-Cas9 gene editing tools and other related technologies has impacted all areas of biology today. It has also raised ethical concerns, particularly with regard to the possibility of generating heritable changes in the human genome - so-called germline gene editing. Although technical and safety issues suggest that this approach is far from clinical application, gene editing as a research tool is moving forward in human embryos, non-human primates and in stem cell-derived embryoids. These studies are already providing new information relevant to our understanding of normal human development, infertility, early pregnancy loss and pluripotent stem cell origins. SN - 1477-9129 UR - https://www.unboundmedicine.com/medline/citation/30045910/Gene_editing_in_human_development:_ethical_concerns_and_practical_applications_ L2 - http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=30045910 DB - PRIME DP - Unbound Medicine ER -