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Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China.
Br J Ophthalmol. 2019 06; 103(6):831-836.BJ

Abstract

BACKGROUND/AIMS

To investigate clinical characteristics and prognosis of paediatric optic neuritis (PON) in patients seropositive for myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in China.

METHODS

Children displaying initial onset of optic neuritis (ON) were recruited from the Neuro-ophthalmology Department in the Chinese People's Liberation Army General Hospital from January 2016 to August 2017. They were assigned into three groups based on antibody status: MOG-Ab-seropositive ON (MOG-ON), aquaporin-4 antibody-seropositive ON (AQP4-ON) and double seronegative ON (seronegative-ON).

RESULTS

Totally 48 patients were assessed, including 25 MOG-ON (52.1%), 7 AQP4-ON (14.6%) and 16 seronegative-ON (33.3%). The MOG-ON and seronegative-ON cohorts had equal ratios of female/male, but the AQP4-ON cohort was predominantly females (100%). The patients with MOG-ON were significantly younger at onset compared with the AQP4-ON group. Of the MOG-ON eyes, 97.6% had good recovery of visual acuity (VA) (≥0.5) compared with33.3% of AQP4-ON eyes (p<0.001). However, there was no significant difference compared with the seronegative-ON eyes (82.6%, p=0.052). Two children in the MOG-ON group ended up being diagnosed with acute disseminated encephalomyelitis, while only one patient in the AQP4-ON group developed neuromyelitis optica during follow-up. Patients with MOG-ON had thicker peripapillary retinal nerve fibre layers overall and in the superior and inferior quadrants than in patients with AQP4-ON (p=0.005, p=0.002 and p=0.024, respectively). In addition, the macular ganglion cell-inner plexiform in MOG-ON eyes became significantly thicker than in AQP4-ON eyes (p=0.029). Orbital MRI revealed a larger proportion of patients with MOG-ON had intracranial optic nerve involvement than patients with seronegative-ON (51.2% vs 17.4%, p=0.009).

CONCLUSION

MOG-ON was the most common PON subtype in China. MOG-ON had different clinical features including earlier age of onset, equal female/male ratio, better recovery of VA and thicker peripapillary retinal nerve fibre and macular ganglion cell-inner plexiform layers. MOG-Abs may be a potential biomarker for determining visual prognosis with PON.

Authors+Show Affiliations

Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China. Joint Shantou International Eye Center, Shantou University and Chinese University of Hong Kong, Shantou, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China weishihui58@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30049802

Citation

Song, Honglu, et al. "Clinical Characteristics and Prognosis of Myelin Oligodendrocyte Glycoprotein Antibody-seropositive Paediatric Optic Neuritis in China." The British Journal of Ophthalmology, vol. 103, no. 6, 2019, pp. 831-836.
Song H, Zhou H, Yang M, et al. Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China. Br J Ophthalmol. 2019;103(6):831-836.
Song, H., Zhou, H., Yang, M., Tan, S., Wang, J., Xu, Q., Liu, H., & Wei, S. (2019). Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China. The British Journal of Ophthalmology, 103(6), 831-836. https://doi.org/10.1136/bjophthalmol-2018-312399
Song H, et al. Clinical Characteristics and Prognosis of Myelin Oligodendrocyte Glycoprotein Antibody-seropositive Paediatric Optic Neuritis in China. Br J Ophthalmol. 2019;103(6):831-836. PubMed PMID: 30049802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China. AU - Song,Honglu, AU - Zhou,Huanfen, AU - Yang,Mo, AU - Tan,Shaoying, AU - Wang,Junqing, AU - Xu,Quangang, AU - Liu,Hongjuan, AU - Wei,Shihui, Y1 - 2018/07/26/ PY - 2018/04/12/received PY - 2018/06/21/revised PY - 2018/07/05/accepted PY - 2018/7/28/pubmed PY - 2019/12/21/medline PY - 2018/7/28/entrez KW - aquaporin-4 antibody KW - myelin oligodendrocyte glycoprotein antibody KW - neuromyelitis optica. KW - pediatric optic neuritis SP - 831 EP - 836 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 103 IS - 6 N2 - BACKGROUND/AIMS: To investigate clinical characteristics and prognosis of paediatric optic neuritis (PON) in patients seropositive for myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in China. METHODS: Children displaying initial onset of optic neuritis (ON) were recruited from the Neuro-ophthalmology Department in the Chinese People's Liberation Army General Hospital from January 2016 to August 2017. They were assigned into three groups based on antibody status: MOG-Ab-seropositive ON (MOG-ON), aquaporin-4 antibody-seropositive ON (AQP4-ON) and double seronegative ON (seronegative-ON). RESULTS: Totally 48 patients were assessed, including 25 MOG-ON (52.1%), 7 AQP4-ON (14.6%) and 16 seronegative-ON (33.3%). The MOG-ON and seronegative-ON cohorts had equal ratios of female/male, but the AQP4-ON cohort was predominantly females (100%). The patients with MOG-ON were significantly younger at onset compared with the AQP4-ON group. Of the MOG-ON eyes, 97.6% had good recovery of visual acuity (VA) (≥0.5) compared with33.3% of AQP4-ON eyes (p<0.001). However, there was no significant difference compared with the seronegative-ON eyes (82.6%, p=0.052). Two children in the MOG-ON group ended up being diagnosed with acute disseminated encephalomyelitis, while only one patient in the AQP4-ON group developed neuromyelitis optica during follow-up. Patients with MOG-ON had thicker peripapillary retinal nerve fibre layers overall and in the superior and inferior quadrants than in patients with AQP4-ON (p=0.005, p=0.002 and p=0.024, respectively). In addition, the macular ganglion cell-inner plexiform in MOG-ON eyes became significantly thicker than in AQP4-ON eyes (p=0.029). Orbital MRI revealed a larger proportion of patients with MOG-ON had intracranial optic nerve involvement than patients with seronegative-ON (51.2% vs 17.4%, p=0.009). CONCLUSION: MOG-ON was the most common PON subtype in China. MOG-ON had different clinical features including earlier age of onset, equal female/male ratio, better recovery of VA and thicker peripapillary retinal nerve fibre and macular ganglion cell-inner plexiform layers. MOG-Abs may be a potential biomarker for determining visual prognosis with PON. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/30049802/Clinical_characteristics_and_prognosis_of_myelin_oligodendrocyte_glycoprotein_antibody_seropositive_paediatric_optic_neuritis_in_China_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&amp;pmid=30049802 DB - PRIME DP - Unbound Medicine ER -