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Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology.
Oxid Med Cell Longev. 2018; 2018:6290931.OM

Abstract

Hydrogen sulfide (H2S) has emerged as a relevant signaling molecule in physiology, taking its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO). After being merely regarded as a toxic poisonous molecule, it is now recognized that mammalian cells are equipped with sophisticated enzymatic systems for H2S production and breakdown. The signaling role of H2S is mainly related to its ability to modify different protein targets, particularly by promoting persulfidation of protein cysteine residues and by interacting with metal centers, mostly hemes. H2S has been shown to regulate a myriad of cellular processes with multiple physiological consequences. As such, dysfunctional H2S metabolism is increasingly implicated in different pathologies, from cardiovascular and neurodegenerative diseases to cancer. As a highly diffusible reactive species, the intra- and extracellular levels of H2S have to be kept under tight control and, accordingly, regulation of H2S metabolism occurs at different levels. Interestingly, even though H2S, NO, and CO have similar modes of action and parallel regulatory targets or precisely because of that, there is increasing evidence of a crosstalk between the three gasotransmitters. Herein are reviewed the biochemistry, metabolism, and signaling function of hydrogen sulfide, as well as its interplay with the other gasotransmitters, NO and CO.

Authors+Show Affiliations

CNR Institute of Molecular Biology and Pathology, Rome, Italy.Instituto de Tecnologia Química e Biológica António Xavier, NOVA University of Lisbon, Av. da República (EAN), 2780-157 Oeiras, Portugal.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30050658

Citation

Giuffrè, Alessandro, and João B. Vicente. "Hydrogen Sulfide Biochemistry and Interplay With Other Gaseous Mediators in Mammalian Physiology." Oxidative Medicine and Cellular Longevity, vol. 2018, 2018, p. 6290931.
Giuffrè A, Vicente JB. Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology. Oxid Med Cell Longev. 2018;2018:6290931.
Giuffrè, A., & Vicente, J. B. (2018). Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology. Oxidative Medicine and Cellular Longevity, 2018, 6290931. https://doi.org/10.1155/2018/6290931
Giuffrè A, Vicente JB. Hydrogen Sulfide Biochemistry and Interplay With Other Gaseous Mediators in Mammalian Physiology. Oxid Med Cell Longev. 2018;2018:6290931. PubMed PMID: 30050658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology. AU - Giuffrè,Alessandro, AU - Vicente,João B, Y1 - 2018/06/27/ PY - 2017/12/01/received PY - 2018/03/13/accepted PY - 2018/7/28/entrez PY - 2018/7/28/pubmed PY - 2018/10/23/medline SP - 6290931 EP - 6290931 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2018 N2 - Hydrogen sulfide (H2S) has emerged as a relevant signaling molecule in physiology, taking its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO). After being merely regarded as a toxic poisonous molecule, it is now recognized that mammalian cells are equipped with sophisticated enzymatic systems for H2S production and breakdown. The signaling role of H2S is mainly related to its ability to modify different protein targets, particularly by promoting persulfidation of protein cysteine residues and by interacting with metal centers, mostly hemes. H2S has been shown to regulate a myriad of cellular processes with multiple physiological consequences. As such, dysfunctional H2S metabolism is increasingly implicated in different pathologies, from cardiovascular and neurodegenerative diseases to cancer. As a highly diffusible reactive species, the intra- and extracellular levels of H2S have to be kept under tight control and, accordingly, regulation of H2S metabolism occurs at different levels. Interestingly, even though H2S, NO, and CO have similar modes of action and parallel regulatory targets or precisely because of that, there is increasing evidence of a crosstalk between the three gasotransmitters. Herein are reviewed the biochemistry, metabolism, and signaling function of hydrogen sulfide, as well as its interplay with the other gasotransmitters, NO and CO. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/30050658/Hydrogen_Sulfide_Biochemistry_and_Interplay_with_Other_Gaseous_Mediators_in_Mammalian_Physiology_ L2 - https://dx.doi.org/10.1155/2018/6290931 DB - PRIME DP - Unbound Medicine ER -