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Association of plasma apolipoprotein CIII, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the clinical features of coronary heart disease in Li and Han ethnic groups in China.
Lipids Health Dis. 2018 Jul 27; 17(1):176.LH

Abstract

BACKGROUND

Apolipoprotein CIII (apoCIII) is an independent risk for coronary heart disease (CHD). In this study, we investigated the associations among plasma apoCIII, hs-CRP and TNF-α levels and their roles in the clinical features of CHD in the Li and Han ethnic groups in China.

METHODS

A cohort of 474 participants was recruited (238 atherosclerotic patients and 236 healthy controls) from the Li and Han ethnic groups. Blood samples were obtained to evaluate apoCIII, TNF-α, hs-CRP and lipid profiles. Chi-squared, t-tests, and Kruskal-Wallis or Wilcoxon-Mann-Whitney tests, Pearson or Spearman correlation tests and multiple unconditional logistic regression were employed to analyze lipid profiles and variations in plasma apoCIII, TNF-α, hs-CRP in subgroups of CHD and their contributions to CHD using SPSS version 20.0 software.

RESULTS

Compared to healthy participants, unfavorable lipid profiles were identified in CHD patients with enhanced systolic pressure, diastolic pressure, fasting blood sugar (FBS), TG, TC, LDL-C, apoB, Lp(a) (P < 0.05, TC and Lp(a); P < 0.01, FBS, TG, LDL-C, apoB); and lower HDL-C and apoAI (P < 0.05). Plasma apoCIII, TNF-α and hs-CRP levels were higher in CHD individuals (16.77 ± 5.98 mg/dL vs. 10.91 ± 4.97 mg/dL; 17.23 ± 6.34 pg/mL vs. 9.49 ± 3.88 pg/mL; 9.55 ± 7.32 mg/L vs. 2.14 ± 1.56 mg/L; P < 0.01 vs. healthy participants). Identical patterns were obtained in the Li and Han groups (16.46 ± 6.08 mg/dL vs. 11.72 ± 5.16 mg/dL; 15.71 ± 5.52 pg/mL vs. 9.74 ± 4.31 pg/mL; 8.21 ± 7.09 mg/L vs. 2.15 ± 1.51 mg/L in Li people; 17.05 ± 5.90 mg/dL vs. 10.07 ± 4.63 mg/dL; 18.59 ± 6.73 pg/mL vs. 9.23 ± 3.38 pg/mL; 10.75 ± 7.44 mg/L vs. 2.12 ± 1.63 mg/L in Han people; P < 0.01). Paired comparisons of subgroups with stable angina, unstable angina, and acute myocardial infarction (AMI) revealed significant variation in plasma levels of apoCIII, TNF-α and hs-CRP (P < 0.01), but not among subgroups with mild, moderate and severe stenosis (P > 0.05). Plasma apoCIII, TNF-α and hs-CRP contributed to the development of CHD (OR = 2.554, 7.252, 6.035, P < 0.01) with paired correlations in CHD patients (apoCIII vs. TNF-α, r = 0.425; apoCIII vs. hs-CRP, r = 0.319; TNF-α vs. hs-CRP, r = 0.400, P < 0.01).

CONCLUSIONS

Association among plasma apoCIII, hs-CRP and TNF-α interacts with unfavorable lipid profiles to contribute to the clinical features of CHD with stable angina, unstable angina, and AMI in the Li and Han ethnic groups in China.

Authors+Show Affiliations

Department of Pharmacology, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan Province, China. Department of Cardiology, People's Hospital of Sanya, Sanya, 572000, Hainan Province, China.Department of Pharmacology, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan Province, China. Department of Cardiology, People's Hospital of Sanya, Sanya, 572000, Hainan Province, China.Department of Anatomy, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan Province, China.Department of Cardiology, People's Hospital of Sanya, Sanya, 572000, Hainan Province, China.Department of Cardiology, People's Hospital of Sanya, Sanya, 572000, Hainan Province, China.Department of Pharmacology, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan Province, China.Department of Pharmacology, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan Province, China.Department of Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan Province, China.Department of Gynecology and Obstetrics, Haikou people's Hospital, Haikou, 570208, Hainan Province, China.Department of Pharmacology, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan Province, China. lyl20041981@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30053815

Citation

Chen, Lin, et al. "Association of Plasma Apolipoprotein CIII, High Sensitivity C-reactive Protein and Tumor Necrosis Factor-α Contributes to the Clinical Features of Coronary Heart Disease in Li and Han Ethnic Groups in China." Lipids in Health and Disease, vol. 17, no. 1, 2018, p. 176.
Chen L, Sun M, Liu H, et al. Association of plasma apolipoprotein CIII, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the clinical features of coronary heart disease in Li and Han ethnic groups in China. Lipids Health Dis. 2018;17(1):176.
Chen, L., Sun, M., Liu, H., Ma, L., Wang, T., Li, P., Lin, M., Lin, H., Chang, P., & Liu, Y. (2018). Association of plasma apolipoprotein CIII, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the clinical features of coronary heart disease in Li and Han ethnic groups in China. Lipids in Health and Disease, 17(1), 176. https://doi.org/10.1186/s12944-018-0830-5
Chen L, et al. Association of Plasma Apolipoprotein CIII, High Sensitivity C-reactive Protein and Tumor Necrosis Factor-α Contributes to the Clinical Features of Coronary Heart Disease in Li and Han Ethnic Groups in China. Lipids Health Dis. 2018 Jul 27;17(1):176. PubMed PMID: 30053815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of plasma apolipoprotein CIII, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the clinical features of coronary heart disease in Li and Han ethnic groups in China. AU - Chen,Lin, AU - Sun,Minzeng, AU - Liu,Hui, AU - Ma,Lihui, AU - Wang,Tiansong, AU - Li,Peiqiong, AU - Lin,Mingqin, AU - Lin,Haifeng, AU - Chang,Penghuan, AU - Liu,Yueli, Y1 - 2018/07/27/ PY - 2018/05/24/received PY - 2018/07/18/accepted PY - 2018/7/29/entrez PY - 2018/7/29/pubmed PY - 2018/11/8/medline KW - ApoCIII KW - Association KW - Coronary artery disease KW - Hs-CRP KW - TNF-α SP - 176 EP - 176 JF - Lipids in health and disease JO - Lipids Health Dis VL - 17 IS - 1 N2 - BACKGROUND: Apolipoprotein CIII (apoCIII) is an independent risk for coronary heart disease (CHD). In this study, we investigated the associations among plasma apoCIII, hs-CRP and TNF-α levels and their roles in the clinical features of CHD in the Li and Han ethnic groups in China. METHODS: A cohort of 474 participants was recruited (238 atherosclerotic patients and 236 healthy controls) from the Li and Han ethnic groups. Blood samples were obtained to evaluate apoCIII, TNF-α, hs-CRP and lipid profiles. Chi-squared, t-tests, and Kruskal-Wallis or Wilcoxon-Mann-Whitney tests, Pearson or Spearman correlation tests and multiple unconditional logistic regression were employed to analyze lipid profiles and variations in plasma apoCIII, TNF-α, hs-CRP in subgroups of CHD and their contributions to CHD using SPSS version 20.0 software. RESULTS: Compared to healthy participants, unfavorable lipid profiles were identified in CHD patients with enhanced systolic pressure, diastolic pressure, fasting blood sugar (FBS), TG, TC, LDL-C, apoB, Lp(a) (P < 0.05, TC and Lp(a); P < 0.01, FBS, TG, LDL-C, apoB); and lower HDL-C and apoAI (P < 0.05). Plasma apoCIII, TNF-α and hs-CRP levels were higher in CHD individuals (16.77 ± 5.98 mg/dL vs. 10.91 ± 4.97 mg/dL; 17.23 ± 6.34 pg/mL vs. 9.49 ± 3.88 pg/mL; 9.55 ± 7.32 mg/L vs. 2.14 ± 1.56 mg/L; P < 0.01 vs. healthy participants). Identical patterns were obtained in the Li and Han groups (16.46 ± 6.08 mg/dL vs. 11.72 ± 5.16 mg/dL; 15.71 ± 5.52 pg/mL vs. 9.74 ± 4.31 pg/mL; 8.21 ± 7.09 mg/L vs. 2.15 ± 1.51 mg/L in Li people; 17.05 ± 5.90 mg/dL vs. 10.07 ± 4.63 mg/dL; 18.59 ± 6.73 pg/mL vs. 9.23 ± 3.38 pg/mL; 10.75 ± 7.44 mg/L vs. 2.12 ± 1.63 mg/L in Han people; P < 0.01). Paired comparisons of subgroups with stable angina, unstable angina, and acute myocardial infarction (AMI) revealed significant variation in plasma levels of apoCIII, TNF-α and hs-CRP (P < 0.01), but not among subgroups with mild, moderate and severe stenosis (P > 0.05). Plasma apoCIII, TNF-α and hs-CRP contributed to the development of CHD (OR = 2.554, 7.252, 6.035, P < 0.01) with paired correlations in CHD patients (apoCIII vs. TNF-α, r = 0.425; apoCIII vs. hs-CRP, r = 0.319; TNF-α vs. hs-CRP, r = 0.400, P < 0.01). CONCLUSIONS: Association among plasma apoCIII, hs-CRP and TNF-α interacts with unfavorable lipid profiles to contribute to the clinical features of CHD with stable angina, unstable angina, and AMI in the Li and Han ethnic groups in China. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/30053815/Association_of_plasma_apolipoprotein_CIII_high_sensitivity_C_reactive_protein_and_tumor_necrosis_factor_��_contributes_to_the_clinical_features_of_coronary_heart_disease_in_Li_and_Han_ethnic_groups_in_China_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0830-5 DB - PRIME DP - Unbound Medicine ER -