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Is it Important to Prevent and Treat Protein-Energy Wasting in Chronic Kidney Disease and Chronic Dialysis Patients?
J Ren Nutr. 2018 11; 28(6):369-379.JR

Abstract

Protein-energy wasting (PEW), which essentially refers to decreased body protein mass and fuel (energy) reserves, is common in advanced chronic kidney disease (CKD) patients and end-stage kidney disease patients undergoing chronic dialysis. The term PEW is used rather than protein-energy malnutrition because many causes of PEW in CKD and end-stage kidney disease patients does not involve reduced nutrient intake (e.g., catabolic illness, oxidants, biologicals lost in urine and dialysate, acidemia). The prevalence of PEW in CKD increases as glomerular filtration rate declines and is highest in chronic dialysis patients. PEW in CKD is important because it is associated with substantially increased morbidity and mortality and reduced quality of life. Many signs of PEW can be improved with nutritional therapy. It is not known whether amelioration or eradication of PEW by treatment of underlying illnesses, nutritional therapy, and/or other measures will reduce morbidity and mortality or improve quality of life. Clinical trials are indicated to answer these questions.

Authors+Show Affiliations

Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California.Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California; David Geffen School of Medicine at UCLA, Los Angeles California.Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California; David Geffen School of Medicine at UCLA, Los Angeles California; UCLA Fielding School of Public Health, Los Angeles, California. Electronic address: jkopple@labiomed.org.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30057212

Citation

Lodebo, Bereket Tessema, et al. "Is It Important to Prevent and Treat Protein-Energy Wasting in Chronic Kidney Disease and Chronic Dialysis Patients?" Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 28, no. 6, 2018, pp. 369-379.
Lodebo BT, Shah A, Kopple JD. Is it Important to Prevent and Treat Protein-Energy Wasting in Chronic Kidney Disease and Chronic Dialysis Patients? J Ren Nutr. 2018;28(6):369-379.
Lodebo, B. T., Shah, A., & Kopple, J. D. (2018). Is it Important to Prevent and Treat Protein-Energy Wasting in Chronic Kidney Disease and Chronic Dialysis Patients? Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 28(6), 369-379. https://doi.org/10.1053/j.jrn.2018.04.002
Lodebo BT, Shah A, Kopple JD. Is It Important to Prevent and Treat Protein-Energy Wasting in Chronic Kidney Disease and Chronic Dialysis Patients. J Ren Nutr. 2018;28(6):369-379. PubMed PMID: 30057212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is it Important to Prevent and Treat Protein-Energy Wasting in Chronic Kidney Disease and Chronic Dialysis Patients? AU - Lodebo,Bereket Tessema, AU - Shah,Anuja, AU - Kopple,Joel D, Y1 - 2018/07/26/ PY - 2018/01/24/received PY - 2018/03/30/revised PY - 2018/04/05/accepted PY - 2018/7/31/pubmed PY - 2019/11/14/medline PY - 2018/7/31/entrez SP - 369 EP - 379 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 28 IS - 6 N2 - Protein-energy wasting (PEW), which essentially refers to decreased body protein mass and fuel (energy) reserves, is common in advanced chronic kidney disease (CKD) patients and end-stage kidney disease patients undergoing chronic dialysis. The term PEW is used rather than protein-energy malnutrition because many causes of PEW in CKD and end-stage kidney disease patients does not involve reduced nutrient intake (e.g., catabolic illness, oxidants, biologicals lost in urine and dialysate, acidemia). The prevalence of PEW in CKD increases as glomerular filtration rate declines and is highest in chronic dialysis patients. PEW in CKD is important because it is associated with substantially increased morbidity and mortality and reduced quality of life. Many signs of PEW can be improved with nutritional therapy. It is not known whether amelioration or eradication of PEW by treatment of underlying illnesses, nutritional therapy, and/or other measures will reduce morbidity and mortality or improve quality of life. Clinical trials are indicated to answer these questions. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/30057212/Is_it_Important_to_Prevent_and_Treat_Protein_Energy_Wasting_in_Chronic_Kidney_Disease_and_Chronic_Dialysis_Patients L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(18)30080-3 DB - PRIME DP - Unbound Medicine ER -