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Olfactory bulb neuroplasticity: A prospective cohort study in patients with chronic rhinosinusitis with nasal polyps.
Clin Otolaryngol. 2018 12; 43(6):1528-1534.CO

Abstract

OBJECTIVES

To compare the olfactory bulb volumes (OBVs) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) to healthy individuals, and to assess the changes of the OBVs in patients with CRSwNP before and after the endoscopic sinus surgery (ESS) utilising magnetic resonance imaging (MRI) with specialised software.

DESIGN

This is a prospective cohort study.

SETTING

Tanta University hospital (tertiary referral hospital), Egypt.

PARTICIPANTS

Thirty patients with CRSwNP (Group A) were compared with thirty healthy individuals (Group B) as regards the OBVs. Patients with CRSwNP underwent ESS where the Smell Identification Test-40 (SIT-40) and the OBVs were assessed pre-operatively and at least 6 months postoperatively. Assessment of the OBVs was carried out using MRI with specialised software.

MAIN OUTCOME MEASURES

Assessment of the volumetric changes of the olfactory bulbs in patients with CRSwNP before and after endoscopic sinus surgery utilise magnetic resonance imaging.

RESULTS

The OBVs were significantly smaller in Group A (58.94 ± 7.96 mm3 and 60.79 ± 8.14 mm3 on the right and left sides, respectively) as compared with the Group B (73.46 ± 8.54 mm3 and 72.96 ± 9.74 mm3 on the right and left sides, respectively). There was also a significant increase in the olfactory bulb volumes as well as improvement of the SIT-40 6 months postoperatively in the Group A.

CONCLUSIONS

The olfactory bulb is characterised by neural plasticity, and its volume may be affected by the peripheral olfactory function.

Authors+Show Affiliations

Otolaryngology/Head and Neck Surgery department, Tanta University, Tanta, Egypt.Otolaryngology/Head and Neck Surgery department, Tanta University, Tanta, Egypt.Otolaryngology/Head and Neck Surgery department, Tanta University, Tanta, Egypt.Radiology and Imaging department, Tanta University, Tanta, Egypt.Radiology and Imaging department, Tanta University, Tanta, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30058179

Citation

Shehata, E M., et al. "Olfactory Bulb Neuroplasticity: a Prospective Cohort Study in Patients With Chronic Rhinosinusitis With Nasal Polyps." Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, vol. 43, no. 6, 2018, pp. 1528-1534.
Shehata EM, Tomoum MO, Amer MA, et al. Olfactory bulb neuroplasticity: A prospective cohort study in patients with chronic rhinosinusitis with nasal polyps. Clin Otolaryngol. 2018;43(6):1528-1534.
Shehata, E. M., Tomoum, M. O., Amer, M. A., Alarabawy, R. A., & Eltomey, M. A. (2018). Olfactory bulb neuroplasticity: A prospective cohort study in patients with chronic rhinosinusitis with nasal polyps. Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 43(6), 1528-1534. https://doi.org/10.1111/coa.13202
Shehata EM, et al. Olfactory Bulb Neuroplasticity: a Prospective Cohort Study in Patients With Chronic Rhinosinusitis With Nasal Polyps. Clin Otolaryngol. 2018;43(6):1528-1534. PubMed PMID: 30058179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olfactory bulb neuroplasticity: A prospective cohort study in patients with chronic rhinosinusitis with nasal polyps. AU - Shehata,E M, AU - Tomoum,M O, AU - Amer,M A, AU - Alarabawy,R A, AU - Eltomey,M A, Y1 - 2018/08/23/ PY - 2018/04/02/received PY - 2018/07/08/revised PY - 2018/07/25/accepted PY - 2018/7/31/pubmed PY - 2019/9/10/medline PY - 2018/7/31/entrez KW - Nasal polyps KW - Olfactory bulb KW - magnetic resonance imaging KW - neural plasticity KW - olfaction KW - quality of life KW - smell SP - 1528 EP - 1534 JF - Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery JO - Clin Otolaryngol VL - 43 IS - 6 N2 - OBJECTIVES: To compare the olfactory bulb volumes (OBVs) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) to healthy individuals, and to assess the changes of the OBVs in patients with CRSwNP before and after the endoscopic sinus surgery (ESS) utilising magnetic resonance imaging (MRI) with specialised software. DESIGN: This is a prospective cohort study. SETTING: Tanta University hospital (tertiary referral hospital), Egypt. PARTICIPANTS: Thirty patients with CRSwNP (Group A) were compared with thirty healthy individuals (Group B) as regards the OBVs. Patients with CRSwNP underwent ESS where the Smell Identification Test-40 (SIT-40) and the OBVs were assessed pre-operatively and at least 6 months postoperatively. Assessment of the OBVs was carried out using MRI with specialised software. MAIN OUTCOME MEASURES: Assessment of the volumetric changes of the olfactory bulbs in patients with CRSwNP before and after endoscopic sinus surgery utilise magnetic resonance imaging. RESULTS: The OBVs were significantly smaller in Group A (58.94 ± 7.96 mm3 and 60.79 ± 8.14 mm3 on the right and left sides, respectively) as compared with the Group B (73.46 ± 8.54 mm3 and 72.96 ± 9.74 mm3 on the right and left sides, respectively). There was also a significant increase in the olfactory bulb volumes as well as improvement of the SIT-40 6 months postoperatively in the Group A. CONCLUSIONS: The olfactory bulb is characterised by neural plasticity, and its volume may be affected by the peripheral olfactory function. SN - 1749-4486 UR - https://www.unboundmedicine.com/medline/citation/30058179/Olfactory_bulb_neuroplasticity:_A_prospective_cohort_study_in_patients_with_chronic_rhinosinusitis_with_nasal_polyps_ L2 - https://doi.org/10.1111/coa.13202 DB - PRIME DP - Unbound Medicine ER -