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Hormonal and metabolic aspects of acne vulgaris in women with polycystic ovary syndrome.
Eur Rev Med Pharmacol Sci. 2018 07; 22(14):4411-4418.ER

Abstract

OBJECTIVE

Acne vulgaris in women can indicate a systemic disease, such as polycystic ovary syndrome (PCOS), which is associated with hormonal and metabolic disorders. The aim of this study was to investigate the influence of hormonal and metabolic disorders on acne vulgaris in women with PCOS.

PATIENTS AND METHODS

The study included 110 women with PCOS. Women were divided according to their androstenedione concentration: within reference range (n=66) or higher (n=44). All patients were between 17-36 years old. Acne was graded according to the US FDA scale for a five-category global system (acne global severity scale). Hirsutism was defined using a modified Ferriman-Gallwey method. Fasting plasma glucose, insulin, luteinizing hormone, follicle-stimulating hormone, 17α-hydroxyprogesterone, 17-beta-estradiol, sex hormone-binding globulin and androgen (androstenedione, total testosterone, free testosterone, dehydroepiandrosterone sulfate) were assessed, as were prolactin and cortisol concentrations. Thyrotropin and free thyroxine concentrations were also measured. The free androgen index (FAI) and homeostatic model assessment-insulin resistance (HOMA-IR) index were calculated.

RESULTS

The average age and rating on the hirsutism scale were similar in both analyzed groups. A higher percentage of severe acne was observed in the group of women with an androstenedione concentration within reference range than in the group with the higher concentration. Meanwhile, the severity of acne in the group of PCOS women with the higher androstenedione concentration was correlated with higher concentrations of total testosterone, free testosterone, dehydroepiandrosterone sulfate, and cortisol. Increased glucose concentration was also proportional to the severity of acne. We did not observe a statistically significant correlation between the severity of acne and the androstenedione concentration. In the group of PCOS women as a whole, the severity of acne was correlated only with higher dehydroepiandrosterone sulfate concentration; other androgens did not affect the severity.

CONCLUSIONS

The acne global severity scale in PCOS women is associated with higher concentrations of total testosterone, free testosterone, dehydroepiandrosterone sulfate, and FAI value. Higher concentrations of androstenedione did not affect acne severity.

Authors+Show Affiliations

Department of Endocrinological Gynecology, Medical University of Silesia, Katowice, Poland. gfranik@sum.edu.pl.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

30058676

Citation

Franik, G, et al. "Hormonal and Metabolic Aspects of Acne Vulgaris in Women With Polycystic Ovary Syndrome." European Review for Medical and Pharmacological Sciences, vol. 22, no. 14, 2018, pp. 4411-4418.
Franik G, Bizoń A, Włoch S, et al. Hormonal and metabolic aspects of acne vulgaris in women with polycystic ovary syndrome. Eur Rev Med Pharmacol Sci. 2018;22(14):4411-4418.
Franik, G., Bizoń, A., Włoch, S., Kowalczyk, K., Biernacka-Bartnik, A., & Madej, P. (2018). Hormonal and metabolic aspects of acne vulgaris in women with polycystic ovary syndrome. European Review for Medical and Pharmacological Sciences, 22(14), 4411-4418. https://doi.org/10.26355/eurrev_201807_15491
Franik G, et al. Hormonal and Metabolic Aspects of Acne Vulgaris in Women With Polycystic Ovary Syndrome. Eur Rev Med Pharmacol Sci. 2018;22(14):4411-4418. PubMed PMID: 30058676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal and metabolic aspects of acne vulgaris in women with polycystic ovary syndrome. AU - Franik,G, AU - Bizoń,A, AU - Włoch,S, AU - Kowalczyk,K, AU - Biernacka-Bartnik,A, AU - Madej,P, PY - 2018/7/31/entrez PY - 2018/7/31/pubmed PY - 2020/1/15/medline SP - 4411 EP - 4418 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 22 IS - 14 N2 - OBJECTIVE: Acne vulgaris in women can indicate a systemic disease, such as polycystic ovary syndrome (PCOS), which is associated with hormonal and metabolic disorders. The aim of this study was to investigate the influence of hormonal and metabolic disorders on acne vulgaris in women with PCOS. PATIENTS AND METHODS: The study included 110 women with PCOS. Women were divided according to their androstenedione concentration: within reference range (n=66) or higher (n=44). All patients were between 17-36 years old. Acne was graded according to the US FDA scale for a five-category global system (acne global severity scale). Hirsutism was defined using a modified Ferriman-Gallwey method. Fasting plasma glucose, insulin, luteinizing hormone, follicle-stimulating hormone, 17α-hydroxyprogesterone, 17-beta-estradiol, sex hormone-binding globulin and androgen (androstenedione, total testosterone, free testosterone, dehydroepiandrosterone sulfate) were assessed, as were prolactin and cortisol concentrations. Thyrotropin and free thyroxine concentrations were also measured. The free androgen index (FAI) and homeostatic model assessment-insulin resistance (HOMA-IR) index were calculated. RESULTS: The average age and rating on the hirsutism scale were similar in both analyzed groups. A higher percentage of severe acne was observed in the group of women with an androstenedione concentration within reference range than in the group with the higher concentration. Meanwhile, the severity of acne in the group of PCOS women with the higher androstenedione concentration was correlated with higher concentrations of total testosterone, free testosterone, dehydroepiandrosterone sulfate, and cortisol. Increased glucose concentration was also proportional to the severity of acne. We did not observe a statistically significant correlation between the severity of acne and the androstenedione concentration. In the group of PCOS women as a whole, the severity of acne was correlated only with higher dehydroepiandrosterone sulfate concentration; other androgens did not affect the severity. CONCLUSIONS: The acne global severity scale in PCOS women is associated with higher concentrations of total testosterone, free testosterone, dehydroepiandrosterone sulfate, and FAI value. Higher concentrations of androstenedione did not affect acne severity. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/30058676/Hormonal_and_metabolic_aspects_of_acne_vulgaris_in_women_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -