Tags

Type your tag names separated by a space and hit enter

Preparation of curcumin-hydroxypropyl-β-cyclodextrin inclusion complex by cosolvency-lyophilization procedure to enhance oral bioavailability of the drug.
Drug Dev Ind Pharm. 2018 Dec; 44(12):1966-1974.DD

Abstract

The curcumin (CUR)-hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex (CUR-HP-β-CD) was prepared to erase its therapeutic restrictions of poor aqueous solubility and low oral bioavailability. CUR-HP-β-CD was prepared by a simple procedure of water-ethanol cosolvent incubation-lyophilization which may be suitable for scale up production, and characterized by Fourier transform-infrared spectroscopy (FT-IR), powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), phase solubility method and dissolution study; the in vitro cytotoxicity was assayed by MTT, whereas the in vivo pharmacokinetics was tested by HPLC in rats receiving formulations via intravenous and oral administration, respectively. CUR was successfully encapsulated in HP-β-CD with a loading capacity of about 1:7 of CUR to HP-β-CD mole ratio, which remarkably enhanced drug water solubility and maintained well the antitumour activity of CUR. The CUR-HP-β-CD and free CUR have a similar pharmacokinetic behaviour in rats after intravenous administration; however, the oral bioavailability of CUR was enhanced to 2.77-fold by the HP-β-CD. The CUR-HP-β-CD can be successfully prepared by a simple method, which may be feasible for industrial scaling up, to remarkably increase drug water solubility and oral bioavailability while maintaining its bioactivity and may be a promising therapeutic preparation.

Authors+Show Affiliations

a School of Pharmacy , Anhui Medical University , Hefei , Anhui Province , China.b School of Biomedical Engineering , Hefei University of Technology , Hefei , Anhui Province , China.a School of Pharmacy , Anhui Medical University , Hefei , Anhui Province , China.a School of Pharmacy , Anhui Medical University , Hefei , Anhui Province , China.a School of Pharmacy , Anhui Medical University , Hefei , Anhui Province , China.a School of Pharmacy , Anhui Medical University , Hefei , Anhui Province , China.a School of Pharmacy , Anhui Medical University , Hefei , Anhui Province , China.a School of Pharmacy , Anhui Medical University , Hefei , Anhui Province , China.a School of Pharmacy , Anhui Medical University , Hefei , Anhui Province , China.a School of Pharmacy , Anhui Medical University , Hefei , Anhui Province , China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30059244

Citation

Li, Ning, et al. "Preparation of Curcumin-hydroxypropyl-β-cyclodextrin Inclusion Complex By Cosolvency-lyophilization Procedure to Enhance Oral Bioavailability of the Drug." Drug Development and Industrial Pharmacy, vol. 44, no. 12, 2018, pp. 1966-1974.
Li N, Wang N, Wu T, et al. Preparation of curcumin-hydroxypropyl-β-cyclodextrin inclusion complex by cosolvency-lyophilization procedure to enhance oral bioavailability of the drug. Drug Dev Ind Pharm. 2018;44(12):1966-1974.
Li, N., Wang, N., Wu, T., Qiu, C., Wang, X., Jiang, S., Zhang, Z., Liu, T., Wei, C., & Wang, T. (2018). Preparation of curcumin-hydroxypropyl-β-cyclodextrin inclusion complex by cosolvency-lyophilization procedure to enhance oral bioavailability of the drug. Drug Development and Industrial Pharmacy, 44(12), 1966-1974. https://doi.org/10.1080/03639045.2018.1505904
Li N, et al. Preparation of Curcumin-hydroxypropyl-β-cyclodextrin Inclusion Complex By Cosolvency-lyophilization Procedure to Enhance Oral Bioavailability of the Drug. Drug Dev Ind Pharm. 2018;44(12):1966-1974. PubMed PMID: 30059244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of curcumin-hydroxypropyl-β-cyclodextrin inclusion complex by cosolvency-lyophilization procedure to enhance oral bioavailability of the drug. AU - Li,Ning, AU - Wang,Ning, AU - Wu,Tingni, AU - Qiu,Changlu, AU - Wang,Xueting, AU - Jiang,Shaohong, AU - Zhang,Zina, AU - Liu,Ting, AU - Wei,Chunliu, AU - Wang,Ting, Y1 - 2018/09/17/ PY - 2018/7/31/pubmed PY - 2019/2/20/medline PY - 2018/7/31/entrez KW - Herbal component KW - anticancer KW - cytotoxicity KW - drug carrier KW - freeze-drying KW - oral administration KW - pharmacokinetics SP - 1966 EP - 1974 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 44 IS - 12 N2 - The curcumin (CUR)-hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex (CUR-HP-β-CD) was prepared to erase its therapeutic restrictions of poor aqueous solubility and low oral bioavailability. CUR-HP-β-CD was prepared by a simple procedure of water-ethanol cosolvent incubation-lyophilization which may be suitable for scale up production, and characterized by Fourier transform-infrared spectroscopy (FT-IR), powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), phase solubility method and dissolution study; the in vitro cytotoxicity was assayed by MTT, whereas the in vivo pharmacokinetics was tested by HPLC in rats receiving formulations via intravenous and oral administration, respectively. CUR was successfully encapsulated in HP-β-CD with a loading capacity of about 1:7 of CUR to HP-β-CD mole ratio, which remarkably enhanced drug water solubility and maintained well the antitumour activity of CUR. The CUR-HP-β-CD and free CUR have a similar pharmacokinetic behaviour in rats after intravenous administration; however, the oral bioavailability of CUR was enhanced to 2.77-fold by the HP-β-CD. The CUR-HP-β-CD can be successfully prepared by a simple method, which may be feasible for industrial scaling up, to remarkably increase drug water solubility and oral bioavailability while maintaining its bioactivity and may be a promising therapeutic preparation. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/30059244/Preparation_of_curcumin_hydroxypropyl_β_cyclodextrin_inclusion_complex_by_cosolvency_lyophilization_procedure_to_enhance_oral_bioavailability_of_the_drug_ L2 - https://www.tandfonline.com/doi/full/10.1080/03639045.2018.1505904 DB - PRIME DP - Unbound Medicine ER -