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The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto's Thyroiditis: A Pilot Study.
Exp Clin Endocrinol Diabetes 2019; 127(7):417-422EC

Abstract

BACKGROUND

Autoimmune thyroid disease is often accompanied by celiac disease.

OBJECTIVE

The purpose of this study was to investigate whether a gluten-free diet affects thyroid autoimmunity, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in women with Hashimoto's thyroiditis and incidentally found positive anti-tissue transglutaminase antibodies.

METHODS

The study included 34 women with autoimmune thyroiditis divided into two group. The patients belonging to the first one (group A, n=16) complied with the gluten-free diet for 6 months, while the remaining patients (group B, n=18) remained without any dietary treatment. Serum titers of thyroid peroxidase and thyroglobulin antibodies, as well as serum levels of thyrotropin, free thyroid hormones and 25-hydroxyvitamin D were measured at the beginning of the study and 6 months later. Based on thyrotropin and free thyroid hormone levels, Jostel's thyrotropin index, the SPINA-GT index and the SPINA-GD index were calculated.

RESULTS

All patients completed the study protocol. In group B, serum thyrotropin and free thyroid hormones levels, serum 25-hydroxyvitamin D levels as well as the calculated indices remained at the similar levels. The gluten-free diet reduced thyroid antibody titers, as well as slightly increased 25-hydroxyvitamin D levels and the SPINA-GT index. In group A, the impact on TPOAb and TgAb titers correlated with the changes in the SPINA-GT index, whereas the impact on TPOAb with the changes in 25-hydroxyvitamin D levels.

CONCLUSIONS

The obtained results suggest that the gluten-free diet may bring clinical benefits to women with autoimmune thyroid disease.

Authors+Show Affiliations

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30060266

Citation

Krysiak, Robert, et al. "The Effect of Gluten-Free Diet On Thyroid Autoimmunity in Drug-Naïve Women With Hashimoto's Thyroiditis: a Pilot Study." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 127, no. 7, 2019, pp. 417-422.
Krysiak R, Szkróbka W, Okopień B. The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto's Thyroiditis: A Pilot Study. Exp Clin Endocrinol Diabetes. 2019;127(7):417-422.
Krysiak, R., Szkróbka, W., & Okopień, B. (2019). The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto's Thyroiditis: A Pilot Study. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 127(7), pp. 417-422. doi:10.1055/a-0653-7108.
Krysiak R, Szkróbka W, Okopień B. The Effect of Gluten-Free Diet On Thyroid Autoimmunity in Drug-Naïve Women With Hashimoto's Thyroiditis: a Pilot Study. Exp Clin Endocrinol Diabetes. 2019;127(7):417-422. PubMed PMID: 30060266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto's Thyroiditis: A Pilot Study. AU - Krysiak,Robert, AU - Szkróbka,Witold, AU - Okopień,Bogusław, Y1 - 2018/07/30/ PY - 2018/7/31/pubmed PY - 2018/7/31/medline PY - 2018/7/31/entrez SP - 417 EP - 422 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp. Clin. Endocrinol. Diabetes VL - 127 IS - 7 N2 - BACKGROUND: Autoimmune thyroid disease is often accompanied by celiac disease. OBJECTIVE: The purpose of this study was to investigate whether a gluten-free diet affects thyroid autoimmunity, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in women with Hashimoto's thyroiditis and incidentally found positive anti-tissue transglutaminase antibodies. METHODS: The study included 34 women with autoimmune thyroiditis divided into two group. The patients belonging to the first one (group A, n=16) complied with the gluten-free diet for 6 months, while the remaining patients (group B, n=18) remained without any dietary treatment. Serum titers of thyroid peroxidase and thyroglobulin antibodies, as well as serum levels of thyrotropin, free thyroid hormones and 25-hydroxyvitamin D were measured at the beginning of the study and 6 months later. Based on thyrotropin and free thyroid hormone levels, Jostel's thyrotropin index, the SPINA-GT index and the SPINA-GD index were calculated. RESULTS: All patients completed the study protocol. In group B, serum thyrotropin and free thyroid hormones levels, serum 25-hydroxyvitamin D levels as well as the calculated indices remained at the similar levels. The gluten-free diet reduced thyroid antibody titers, as well as slightly increased 25-hydroxyvitamin D levels and the SPINA-GT index. In group A, the impact on TPOAb and TgAb titers correlated with the changes in the SPINA-GT index, whereas the impact on TPOAb with the changes in 25-hydroxyvitamin D levels. CONCLUSIONS: The obtained results suggest that the gluten-free diet may bring clinical benefits to women with autoimmune thyroid disease. SN - 1439-3646 UR - https://www.unboundmedicine.com/medline/citation/30060266/The_Effect_of_Gluten_Free_Diet_on_Thyroid_Autoimmunity_in_Drug_Naïve_Women_with_Hashimoto's_Thyroiditis:_A_Pilot_Study_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/a-0653-7108 DB - PRIME DP - Unbound Medicine ER -