TY - JOUR T1 - Metabolite Profiles, Bioactivity, and HPLC Fingerprint of Different Varieties of Eucommia ulmoides Oliv.: Towards the Utilization of Medicinal and Commercial Chinese Endemic Tree. AU - Wu,Dong, AU - Yu,Danmeng, AU - Zhang,Yujia, AU - Dong,Juane, AU - Li,Dengwu, AU - Wang,Dongmei, Y1 - 2018/07/30/ PY - 2018/07/04/received PY - 2018/07/19/revised PY - 2018/07/25/accepted PY - 2018/8/1/entrez PY - 2018/8/1/pubmed PY - 2018/11/6/medline KW - Eucommia ulmoides Oliv. KW - HPLC fingerprint KW - bioactivity KW - chemometrics analysis KW - different varieties KW - metabolite profiles JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 8 N2 - Eucommia ulmoides Oliv. is widely regarded in China as a precious medicinal and commercial endemic tree. Due to cross-breeding or natural variation of E. ulmoides, the metabolite composition may vary significantly, making control of the medical quality difficult. In order to improve the rational development and utilization, the quality of seven varieties of E. ulmoides were evaluated based on metabolite profiles (total phenolic, total flavonoid, gutta-percha, aucubin, geniposidic acid, chlorogenic acid, geniposide, pinoresinol diglucoside, rutin, hyperoside, and astragalin), bioactivities (in vitro, in vivo antioxidant activities, and antibacterial activities) and HPLC fingerprint combined with chemometrics analysis. On this basis, the differences of medicinal parts (leaf and bark) were further carried out. For the traditional use of bark, Purple-leaf E. ulmoides was the most suitable. For the use of leaf, Qinzhong 1 and Purple-leaf E. ulmoides were appropriate. HPLC fingerprint analysis showed that significant differences in metabolite profiles exist among seven varieties of E. ulmoides. Combined with chemometrics analysis, seven varieties of E. ulmoides were divided into three groups from the use of leaf and bark. The analysis not only evaluated quality of seven varieties of E. ulmoides, but also could distinguish different varieties and different regions of origin. The results can provide theoretical basis for E. ulmoides resources utilization and cultivation of fine varieties. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/30061494/Metabolite_Profiles_Bioactivity_and_HPLC_Fingerprint_of_Different_Varieties_of_Eucommia_ulmoides_Oliv_:_Towards_the_Utilization_of_Medicinal_and_Commercial_Chinese_Endemic_Tree_ DB - PRIME DP - Unbound Medicine ER -