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Fasting plasma glucose is a stronger predictor of diabetes than triglyceride-glucose index, triglycerides/high-density lipoprotein cholesterol, and homeostasis model assessment of insulin resistance: Tehran Lipid and Glucose Study.
Acta Diabetol. 2018 Oct; 55(10):1067-1074.AD

Abstract

AIMS

To compare the impact of triglyceride-glucose index (TyG-index), the product of fasting plasma glucose (FPG) and triglycerides (TG) with FPG, 2 h post-challenge plasma glucose (2 h-PCPG), TG/high-density lipoprotein cholesterol (TG/HDL-C), and homeostasis model assessment of insulin resistance (HOMA-IR) indices for prediction of type 2 diabetes (T2D) in Iranian adults during a median follow-up of 12 years.

METHODS

Study population included 4419 (1858 men) subjects with mean age of 40.6 ± 13.2 years. Multivariable Cox proportional hazard models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for each 1-standard deviation increase in each predictor. Areas under the receiver operating characteristics curves (AUC) and 95% CIs were calculated.

RESULTS

During follow-up, 215 men and 288 women developed T2D. The multivariable HRs for FPG, 2 h-PCPG, TyG-index, HOMA-IR, HOMA2-IR, and TG/HDL-C were 2.20, 1.97, 1.71, 1.33, 1.30, and 1.35 in men and 2.13, 2.11, 1.44, 1.37, 1.32, and 1.36 in women (all P < 0.001). Among the total population, the AUC for FPG [0.752 (0.727-0.776)] was similar to 2 h-PCPG but higher than TyG-index [0.697 (0.673-0.720)], TG/HDL-C [0.644 (0.620-0.669)], HOMA-IR [0.684 (0.659-0.710)], and HOMA2-IR [0.656 (0.630-0.682)]. In men, AUC of TyG-index was higher than TG/HDL-C but did not differ with HOMA-IR indices. In women, the AUC of TyG-index was higher than HOMA2-IR and TG/HDL-C, but was similar to that of HOMA-IR.

CONCLUSIONS

FPG is a stronger predictor of T2D than the TyG-index, TG/HDL-C, and HOMA-IR indices. Although TyG-index was better than TG/HDL-C in both genders, it did not rank above HOMA-IR.

Authors+Show Affiliations

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, No. 24, Aarabi St. Velenjak area, Tehran, Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, No. 24, Aarabi St. Velenjak area, Tehran, Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, No. 24, Aarabi St. Velenjak area, Tehran, Iran.Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, Aarabi St. Velenjak area, Tehran, Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, No. 24, Aarabi St. Velenjak area, Tehran, Iran. fzhadaegh@endocrine.ac.ir.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30066042

Citation

Tohidi, Maryam, et al. "Fasting Plasma Glucose Is a Stronger Predictor of Diabetes Than Triglyceride-glucose Index, Triglycerides/high-density Lipoprotein Cholesterol, and Homeostasis Model Assessment of Insulin Resistance: Tehran Lipid and Glucose Study." Acta Diabetologica, vol. 55, no. 10, 2018, pp. 1067-1074.
Tohidi M, Baghbani-Oskouei A, Ahanchi NS, et al. Fasting plasma glucose is a stronger predictor of diabetes than triglyceride-glucose index, triglycerides/high-density lipoprotein cholesterol, and homeostasis model assessment of insulin resistance: Tehran Lipid and Glucose Study. Acta Diabetol. 2018;55(10):1067-1074.
Tohidi, M., Baghbani-Oskouei, A., Ahanchi, N. S., Azizi, F., & Hadaegh, F. (2018). Fasting plasma glucose is a stronger predictor of diabetes than triglyceride-glucose index, triglycerides/high-density lipoprotein cholesterol, and homeostasis model assessment of insulin resistance: Tehran Lipid and Glucose Study. Acta Diabetologica, 55(10), 1067-1074. https://doi.org/10.1007/s00592-018-1195-y
Tohidi M, et al. Fasting Plasma Glucose Is a Stronger Predictor of Diabetes Than Triglyceride-glucose Index, Triglycerides/high-density Lipoprotein Cholesterol, and Homeostasis Model Assessment of Insulin Resistance: Tehran Lipid and Glucose Study. Acta Diabetol. 2018;55(10):1067-1074. PubMed PMID: 30066042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting plasma glucose is a stronger predictor of diabetes than triglyceride-glucose index, triglycerides/high-density lipoprotein cholesterol, and homeostasis model assessment of insulin resistance: Tehran Lipid and Glucose Study. AU - Tohidi,Maryam, AU - Baghbani-Oskouei,Aidin, AU - Ahanchi,Noushin Sadat, AU - Azizi,Fereidoun, AU - Hadaegh,Farzad, Y1 - 2018/07/31/ PY - 2018/05/27/received PY - 2018/07/17/accepted PY - 2018/8/2/pubmed PY - 2018/10/27/medline PY - 2018/8/2/entrez KW - Cohort study KW - Glucose KW - Insulin resistance KW - Triglycerides KW - Type 2 diabetes SP - 1067 EP - 1074 JF - Acta diabetologica JO - Acta Diabetol VL - 55 IS - 10 N2 - AIMS: To compare the impact of triglyceride-glucose index (TyG-index), the product of fasting plasma glucose (FPG) and triglycerides (TG) with FPG, 2 h post-challenge plasma glucose (2 h-PCPG), TG/high-density lipoprotein cholesterol (TG/HDL-C), and homeostasis model assessment of insulin resistance (HOMA-IR) indices for prediction of type 2 diabetes (T2D) in Iranian adults during a median follow-up of 12 years. METHODS: Study population included 4419 (1858 men) subjects with mean age of 40.6 ± 13.2 years. Multivariable Cox proportional hazard models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for each 1-standard deviation increase in each predictor. Areas under the receiver operating characteristics curves (AUC) and 95% CIs were calculated. RESULTS: During follow-up, 215 men and 288 women developed T2D. The multivariable HRs for FPG, 2 h-PCPG, TyG-index, HOMA-IR, HOMA2-IR, and TG/HDL-C were 2.20, 1.97, 1.71, 1.33, 1.30, and 1.35 in men and 2.13, 2.11, 1.44, 1.37, 1.32, and 1.36 in women (all P < 0.001). Among the total population, the AUC for FPG [0.752 (0.727-0.776)] was similar to 2 h-PCPG but higher than TyG-index [0.697 (0.673-0.720)], TG/HDL-C [0.644 (0.620-0.669)], HOMA-IR [0.684 (0.659-0.710)], and HOMA2-IR [0.656 (0.630-0.682)]. In men, AUC of TyG-index was higher than TG/HDL-C but did not differ with HOMA-IR indices. In women, the AUC of TyG-index was higher than HOMA2-IR and TG/HDL-C, but was similar to that of HOMA-IR. CONCLUSIONS: FPG is a stronger predictor of T2D than the TyG-index, TG/HDL-C, and HOMA-IR indices. Although TyG-index was better than TG/HDL-C in both genders, it did not rank above HOMA-IR. SN - 1432-5233 UR - https://www.unboundmedicine.com/medline/citation/30066042/Fasting_plasma_glucose_is_a_stronger_predictor_of_diabetes_than_triglyceride_glucose_index_triglycerides/high_density_lipoprotein_cholesterol_and_homeostasis_model_assessment_of_insulin_resistance:_Tehran_Lipid_and_Glucose_Study_ L2 - https://dx.doi.org/10.1007/s00592-018-1195-y DB - PRIME DP - Unbound Medicine ER -