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Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks.
Psychopharmacology (Berl). 2018 Sep; 235(9):2725-2737.P

Abstract

RATIONALE

Alcohol-associated stimuli capture attention, yet drinkers differ in the precise stimuli that become paired with intoxication.

OBJECTIVES

Extending our prior work to examine the influence of alcoholism risk factors, we paired abstract visual stimuli with intravenous alcohol delivered covertly and examined brain responses to these Pavlovian-conditioned stimuli in fMRI when subjects were not intoxicated.

METHODS

Sixty healthy drinkers performed task-irrelevant alcohol conditioning that presented geometric shapes as conditioned stimuli. Shapes were paired with a rapidly rising alcohol limb (conditioned stimulus; CS+) using intravenous alcohol infusion targeting a final peak breath alcohol concentration of 0.045 g/dL or saline (CS-) infusion at matched rates. On day 2, subjects performed monetary delay discounting outside the scanner to assess delay tolerance and then underwent event-related fMRI while performing the same task with CS+, CS-, and an irrelevant symbol.

RESULTS

CS+ elicited stronger activation than CS- in frontoparietal executive/attention and orbitofrontal reward-associated networks. Risk factors including family history, recent drinking, sex, and age of drinking onset did not relate to the [CS+ > CS-] activation. Delay-tolerant choice and [CS+ > CS-] activation in right inferior parietal cortex were positively related.

CONCLUSIONS

Networks governing executive attention and reward showed enhanced responses to stimuli experimentally paired with intoxication, with the right parietal cortex implicated in both alcohol cue pairing and intertemporal choice. While different from our previous study results in 14 men, we believe this paradigm in a large sample of male and female drinkers offers novel insights into Pavlovian processes less affected by idiosyncratic drug associations.

Authors+Show Affiliations

Department of Psychiatry, School of Medicine, Indiana University, 355 W. 16th Street (GH 4800), Indianapolis, IN, 46202, USA. boberlin@iupui.edu. Department of Neurology, School of Medicine, Indiana University, Indianapolis, IN, USA. boberlin@iupui.edu. Stark Neurosciences Institute, School of Medicine, Indiana University, Indianapolis, IN, USA. boberlin@iupui.edu. Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA. boberlin@iupui.edu.Department of Neurology, School of Medicine, Indiana University, Indianapolis, IN, USA. Department of Radiology and Imaging Sciences, School of Medicine, Indiana University, Indianapolis, IN, USA.Department of Neurology, School of Medicine, Indiana University, Indianapolis, IN, USA.Department of Neurology, School of Medicine, Indiana University, Indianapolis, IN, USA.Department of Neurology, School of Medicine, Indiana University, Indianapolis, IN, USA.Department of Psychiatry, School of Medicine, Indiana University, 355 W. 16th Street (GH 4800), Indianapolis, IN, 46202, USA.Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.Department of Psychiatry, School of Medicine, Indiana University, 355 W. 16th Street (GH 4800), Indianapolis, IN, 46202, USA. Roudebush Veteran's Administration Medical Center, Indianapolis, IN, USA.Department of Psychiatry, School of Medicine, Indiana University, 355 W. 16th Street (GH 4800), Indianapolis, IN, 46202, USA. Department of Neurology, School of Medicine, Indiana University, Indianapolis, IN, USA. Stark Neurosciences Institute, School of Medicine, Indiana University, Indianapolis, IN, USA. Department of Radiology and Imaging Sciences, School of Medicine, Indiana University, Indianapolis, IN, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30066136

Citation

Oberlin, Brandon G., et al. "Pairing Neutral Cues With Alcohol Intoxication: New Findings in Executive and Attention Networks." Psychopharmacology, vol. 235, no. 9, 2018, pp. 2725-2737.
Oberlin BG, Dzemidzic M, Eiler WJA, et al. Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks. Psychopharmacology (Berl). 2018;235(9):2725-2737.
Oberlin, B. G., Dzemidzic, M., Eiler, W. J. A., Carron, C. R., Soeurt, C. M., Plawecki, M. H., Grahame, N. J., O'Connor, S. J., & Kareken, D. A. (2018). Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks. Psychopharmacology, 235(9), 2725-2737. https://doi.org/10.1007/s00213-018-4968-7
Oberlin BG, et al. Pairing Neutral Cues With Alcohol Intoxication: New Findings in Executive and Attention Networks. Psychopharmacology (Berl). 2018;235(9):2725-2737. PubMed PMID: 30066136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks. AU - Oberlin,Brandon G, AU - Dzemidzic,Mario, AU - Eiler,William J A,2nd AU - Carron,Claire R, AU - Soeurt,Christina M, AU - Plawecki,Martin H, AU - Grahame,Nicholas J, AU - O'Connor,Sean J, AU - Kareken,David A, Y1 - 2018/08/01/ PY - 2018/03/13/received PY - 2018/07/05/accepted PY - 2018/8/2/pubmed PY - 2018/11/7/medline PY - 2018/8/2/entrez KW - Addiction KW - Alcoholism KW - Associative conditioning KW - BA 40 KW - Classical conditioning KW - Cue reactivity KW - Ethanol KW - Intertemporal choice KW - Laboratory task SP - 2725 EP - 2737 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 235 IS - 9 N2 - RATIONALE: Alcohol-associated stimuli capture attention, yet drinkers differ in the precise stimuli that become paired with intoxication. OBJECTIVES: Extending our prior work to examine the influence of alcoholism risk factors, we paired abstract visual stimuli with intravenous alcohol delivered covertly and examined brain responses to these Pavlovian-conditioned stimuli in fMRI when subjects were not intoxicated. METHODS: Sixty healthy drinkers performed task-irrelevant alcohol conditioning that presented geometric shapes as conditioned stimuli. Shapes were paired with a rapidly rising alcohol limb (conditioned stimulus; CS+) using intravenous alcohol infusion targeting a final peak breath alcohol concentration of 0.045 g/dL or saline (CS-) infusion at matched rates. On day 2, subjects performed monetary delay discounting outside the scanner to assess delay tolerance and then underwent event-related fMRI while performing the same task with CS+, CS-, and an irrelevant symbol. RESULTS: CS+ elicited stronger activation than CS- in frontoparietal executive/attention and orbitofrontal reward-associated networks. Risk factors including family history, recent drinking, sex, and age of drinking onset did not relate to the [CS+ > CS-] activation. Delay-tolerant choice and [CS+ > CS-] activation in right inferior parietal cortex were positively related. CONCLUSIONS: Networks governing executive attention and reward showed enhanced responses to stimuli experimentally paired with intoxication, with the right parietal cortex implicated in both alcohol cue pairing and intertemporal choice. While different from our previous study results in 14 men, we believe this paradigm in a large sample of male and female drinkers offers novel insights into Pavlovian processes less affected by idiosyncratic drug associations. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/30066136/Pairing_neutral_cues_with_alcohol_intoxication:_new_findings_in_executive_and_attention_networks_ L2 - https://dx.doi.org/10.1007/s00213-018-4968-7 DB - PRIME DP - Unbound Medicine ER -