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Possible involvement of eicosanoids in the pharmacological action of bromelain.
Arzneimittelforschung. 1986; 36(1):110-2.A

Abstract

Bromelain, a proteolytic enzyme extracted from pineapple plants, was investigated for its capacity to interfere with arachidonic acid metabolism, since prostaglandins and other eicosanoids are well-known to be involved in the pathogenesis of inflammatory diseases. Bromelain was tested for its ability to interfere with eicosanoids generation in vivo in two experimentally-induced inflammatory reactions in the rat. Also antiplatelet aggregation activity of bromelain was studied in ex vivo rat platelets. The results seem to indicate an interference of bromelain with arachidonic acid cascade, which, however, deserves further investigation to be better assessed.

Authors

Vellini M
No affiliation info available
Desideri D
No affiliation info available
Milanese A
No affiliation info available
Omini C
No affiliation info available
Daffonchio L
No affiliation info available
Hernandez A
No affiliation info available
Brunelli G
No affiliation info available

MeSH

AnimalsArachidonic AcidArachidonic AcidsBromelainsDinoprostoneExudates and TransudatesIndomethacinInflammationLeukotriene B4LipoxygenaseMalePlatelet AggregationProstaglandins ERatsRats, Inbred StrainsThromboxane B2

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3006709

Citation

Vellini, M, et al. "Possible Involvement of Eicosanoids in the Pharmacological Action of Bromelain." Arzneimittel-Forschung, vol. 36, no. 1, 1986, pp. 110-2.
Vellini M, Desideri D, Milanese A, et al. Possible involvement of eicosanoids in the pharmacological action of bromelain. Arzneimittelforschung. 1986;36(1):110-2.
Vellini, M., Desideri, D., Milanese, A., Omini, C., Daffonchio, L., Hernandez, A., & Brunelli, G. (1986). Possible involvement of eicosanoids in the pharmacological action of bromelain. Arzneimittel-Forschung, 36(1), 110-2.
Vellini M, et al. Possible Involvement of Eicosanoids in the Pharmacological Action of Bromelain. Arzneimittelforschung. 1986;36(1):110-2. PubMed PMID: 3006709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible involvement of eicosanoids in the pharmacological action of bromelain. AU - Vellini,M, AU - Desideri,D, AU - Milanese,A, AU - Omini,C, AU - Daffonchio,L, AU - Hernandez,A, AU - Brunelli,G, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 110 EP - 2 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 36 IS - 1 N2 - Bromelain, a proteolytic enzyme extracted from pineapple plants, was investigated for its capacity to interfere with arachidonic acid metabolism, since prostaglandins and other eicosanoids are well-known to be involved in the pathogenesis of inflammatory diseases. Bromelain was tested for its ability to interfere with eicosanoids generation in vivo in two experimentally-induced inflammatory reactions in the rat. Also antiplatelet aggregation activity of bromelain was studied in ex vivo rat platelets. The results seem to indicate an interference of bromelain with arachidonic acid cascade, which, however, deserves further investigation to be better assessed. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/3006709/Possible_involvement_of_eicosanoids_in_the_pharmacological_action_of_bromelain_ DB - PRIME DP - Unbound Medicine ER -