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A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials.
Biomed Res Int. 2018; 2018:7474207.BR

Abstract

Objective

The study aims to systematically evaluate the clinical effect of gabapentin in the treatment of postherpetic neuralgia (PHN).

Method

Data were retrieved electronically from PubMed, Embase, CNKI, the China Biomedical Database, and the Library of Clinical Database, beginning from the time of inception to April 2017, in order to collect data on randomized controlled trials (RCTs) of gabapentin and placebo in PHN treatment.

Results

A total of 11 RCTs (2376 people) were retrieved. The gabapentin group reported significantly reduced pain intensity [MD=-0.91, 95% CI -1.32 to -0.51, P<0.00001] compared with the placebo group. Those treated with gabapentin also experienced significantly improved sleep quality [SMD=-0.44, 95% CI -0.66 to -0.23, P<0.0001], but were more likely to experience incidence of adverse events, such as somnolence, dizziness, and peripheral edema. Results of the subgroup analysis showed that the source of heterogeneity may be related to the formulations of the drug.

Conclusion

Gabapentin can be used to effectively and safely treat PHN.

Authors+Show Affiliations

Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, China.Department of Urology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, China.Electrophysiological Laboratory, Laboratory of Xinjiang Endemic and Ethnic Diseases, China.Electrophysiological Laboratory, Laboratory of Xinjiang Endemic and Ethnic Diseases, China.Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, China.Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, China.Electrophysiological Laboratory, Laboratory of Xinjiang Endemic and Ethnic Diseases, China. Department of Physiology, Medical College of Shihezi University, Shihezi, Xinjiang 832002, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

30069477

Citation

Zhang, Meng, et al. "A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia From Randomized Controlled Trials." BioMed Research International, vol. 2018, 2018, p. 7474207.
Zhang M, Gao CX, Ma KT, et al. A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials. Biomed Res Int. 2018;2018:7474207.
Zhang, M., Gao, C. X., Ma, K. T., Li, L., Dai, Z. G., Wang, S., & Si, J. Q. (2018). A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials. BioMed Research International, 2018, 7474207. https://doi.org/10.1155/2018/7474207
Zhang M, et al. A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia From Randomized Controlled Trials. Biomed Res Int. 2018;2018:7474207. PubMed PMID: 30069477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials. AU - Zhang,Meng, AU - Gao,Cun-Xiang, AU - Ma,Ke-Tao, AU - Li,Li, AU - Dai,Zhi-Gang, AU - Wang,Sheng, AU - Si,Jun-Qiang, Y1 - 2018/07/04/ PY - 2017/08/18/received PY - 2018/03/28/revised PY - 2018/05/28/accepted PY - 2018/8/3/entrez PY - 2018/8/3/pubmed PY - 2019/1/8/medline SP - 7474207 EP - 7474207 JF - BioMed research international JO - Biomed Res Int VL - 2018 N2 - Objective: The study aims to systematically evaluate the clinical effect of gabapentin in the treatment of postherpetic neuralgia (PHN). Method: Data were retrieved electronically from PubMed, Embase, CNKI, the China Biomedical Database, and the Library of Clinical Database, beginning from the time of inception to April 2017, in order to collect data on randomized controlled trials (RCTs) of gabapentin and placebo in PHN treatment. Results: A total of 11 RCTs (2376 people) were retrieved. The gabapentin group reported significantly reduced pain intensity [MD=-0.91, 95% CI -1.32 to -0.51, P<0.00001] compared with the placebo group. Those treated with gabapentin also experienced significantly improved sleep quality [SMD=-0.44, 95% CI -0.66 to -0.23, P<0.0001], but were more likely to experience incidence of adverse events, such as somnolence, dizziness, and peripheral edema. Results of the subgroup analysis showed that the source of heterogeneity may be related to the formulations of the drug. Conclusion: Gabapentin can be used to effectively and safely treat PHN. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/30069477/A_Meta_Analysis_of_Therapeutic_Efficacy_and_Safety_of_Gabapentin_in_the_Treatment_of_Postherpetic_Neuralgia_from_Randomized_Controlled_Trials_ L2 - https://dx.doi.org/10.1155/2018/7474207 DB - PRIME DP - Unbound Medicine ER -